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Wednesday 13 May

Machine Learning (Statistics)

Generative Modeling of Approximately Periodic Time Series by a Posterior-Weighted Gaussian Process

Discrete automated processes in industrial and cyber-physical systems often exhibit a repetitive structure in which successive repetitions follow a common trajectory while differing in duration, amplitude, and fine-scale dynamics. Such approximately periodic behavior poses a challenge for Gaussian Processes (GP) modeling: strictly periodic models suppress inter-repetition variability, while non-periodic models fail to capture the strong structural regularities required for generation. In this work, we propose a stochastic generative model for approximately periodic time series. The model is based on a GP whose posterior is modulated by a novel kernel. Our approach decouples intra-repetition structure from inter-repetition variability through a two-stage construction which yields a generative distribution with a identical mean function across repetitions, while allowing smooth variation between repetitions. The modeling choices are supported by an implementation in which realistic synthetic trajectories are generated from toy datasets.
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Machine Learning (Statistics)

On Hallucinations in Inverse Problems: Fundamental Limits and Provable Assessment Methods

Artificial intelligence (AI) has transformed imaging inverse problems, from medical diagnostics to Earth observation. Yet deep neural networks can produce hallucinations, realistic-looking but incorrect details, undermining their reliability, especially when ground truth data is unavailable. We develop a theoretical framework showing that such hallucinations are not merely artifacts of particular models, but can arise from the ill-posed nature of the inverse problem itself. We derive necessary and sufficient conditions for hallucinations, together with computable bounds on their magnitude that depend only on the forward model. Building on this theory, we introduce algorithms to: (1) estimate the minimum hallucination magnitude achievable by any reconstruction model for a given input; (2) assess the faithfulness of reconstructed details by a given reconstruction model. Experiments across three imaging tasks demonstrate that our approach applies broadly, including to modern generative models, and provides a principled way to quantify and evaluate AI hallucinations.
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All authors David Iagaru, Nina M. Gottschling, Anders C. Hansen, Josselin Garnier

Machine Learning (Statistics)

Amortized Neural Clustering of Time Series based on Statistical Features

This paper introduces an algorithm-agnostic approach to feature-based time series clustering via amortized neural inference. By training neural networks to approximate the optimal partitioning rule from simulated data, the proposed framework reduces reliance on conventional clustering methods, such as $K$-means, $K$-medoids, or hierarchical clustering, and their associated objective functions and heuristics. Leveraging statistical features, such as autocorrelations and quantile autocorrelations, the approach learns a data-driven affinity structure from which clustering partitions can be recovered, without requiring explicit prior specification of cluster shapes or structures. In addition, one version of the method can automatically determine the number of clusters, avoiding ad-hoc selection procedures. Comprehensive empirical studies show that the proposed framework achieves competitive or superior clustering accuracy relative to traditional methods, even in challenging scenarios where competing techniques are provided with the true number of clusters. An application to financial time series of stock returns illustrates its practical utility. By reducing the need for algorithm selection and calibration, the proposed framework opens new possibilities for automated, adaptive, and data-driven clustering of temporal data across scientific and industrial domains.
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Machine Learning (Statistics)

State-of-art minibatches via novel DPP kernels: discretization, wavelets, and rough objectives

Determinantal point processes (DPPs) have emerged as a kernelized alternative to vanilla independent sampling for generating efficient minibatches, coresets and other parsimonious representations of large-scale datasets. While theoretical foundations and promising empirical performance have been demonstrated, there are two challenges for current proposals for DPP-based coresets or minibatches. The first is the need for families of DPPs with certain key variance reduction properties, usually constructed in a continuous setting, of which there are few known examples. The second is the need for an ad-hoc construction of a discrete DPP defined on a given dataset, that inherits such variance reduction. In this work, we contribute to the programme of establishing DPPs as a subsampling toolbox for ML by advancing on these two fronts. First, we propose new DPPs on the Euclidean space based on wavelets, with provably better accuracy guarantees than the best known rates. Second, we introduce a general method to convert such continuous DPPs, which are more amenable to proving analytical statements, into discrete kernels, which are pertinent for subsampling tasks such as minibatch and coreset constructions. This conversion mechanism simultaneously preserves the desired variance decay and reveals a low-rank decomposition of the discrete kernel, which makes sampling the corresponding DPP computationally inexpensive. En route, we enlarge the class of ML tasks amenable to improvements via DPP-based minibatches and coresets to include objective functions with arbitrarily low regularity, and rate guarantees that explicitly adapt to this regularity.
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All authors Hoang-Son Tran, Pranav Gupta, Rémi Bardenet, Subhroshekhar Ghosh

Machine Learning (Statistics)

Adaptive Kernel Density Estimation with Pre-training

Density estimation in high-dimensional settings is an important and challenging statistical problem.Traditional methods based on kernel smoothing are inefficient in high dimensions due to the difficulties in specifying appropriate location-adaptive kernels. In this work, we introduce pre-training, a key idea behind many cutting-edge AI technologies, to the context of non-parametric density estimation. By establishing a pre-trained neural network that can recommend an appropriate location-adaptive kernel for each sample point, efficient density estimation with adaptive kernels is achieved in high dimensions. A wide range of numerical experiments show that this strategy is highly effective for improving density-estimation accuracy, when the target distribution is close to the distribution family for pre-training. When the target distribution is substantially different from the pre-training distribution family, the benefit from the proposed pre-training strategy may be diluted, but can be reactivated by an additional fine-tuning procedure.
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Statistics Theory · Cross-listed from math.PR

Orientation in Poisson Cluster Processes via Imaginary Bispectra

We study what remains detectable about one-sided Poisson cluster processes after cluster orientation is erased. We construct matched reversible cluster nulls preserving intensity and the full Bartlett spectrum, showing that second-order structure alone need not identify temporal direction. For stationary Poisson branching clusters, we derive the Fourier–Stieltjes transform of the reduced third cumulant and show that, in the $L^1$ third-cumulant regime, a nonzero imaginary factorial bispectrum certifies orientation. We also give explicit orientation-erased nulls, reversible spectral matches for monotone Hawkes kernels, and finite-window third-order orientation contrasts.
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All authors Conor Kresin, Yifu Tang, Boris Baeumer, Ting Wang

Statistics Applications

Enhancing a Risk Model by Adding Transient Statistical Factors

Estimating the covariance of asset returns, i.e., the risk model, is a key component of financial portfolio construction and evaluation. Most risk modeling approaches produce a factor model that decomposes the asset variability into two components: the first attributed to a small number of factors that are common among the assets and the second attributed to the idiosyncratic behavior of each asset. Third-party providers typically provide risk models to investors, and while these models are typically of high quality, they may fail to capture important information, e.g., changing market regimes and transient factors. To overcome these limitations, we propose a systematic method based on maximum likelihood estimation to enhance an existing factor model by both refining the given model and adding new statistical factors. Our approach relies only on the observed sequence of realized returns and on the choice of two hyperparameters: the number of additional factors and the half-life parameter that determines the weights assigned to returns in the log-likelihood objective. Importantly, our methodology applies to the situation where asset returns may be missing, making it suitable for typical equity datasets. We demonstrate our approach on the Barra short-term US risk model, a high-quality risk model used in practice, for a universe of US high-capitalization equities. We show that the proposed extension captures structure in the returns that is missed by the original model.
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All authors Alexandros E. Tzikas, Emmanuel J. Candès, Trevor Hastie, Stephen P. Boyd, Mykel J. Kochenderfer, Ronald N. Kahn

Machine Learning (Statistics)

Coreset-Induced Conditional Velocity Flow Matching

We propose Coreset-Induced Conditional Velocity Flow Matching (CCVFM), a generative model that augments hierarchical rectified flow with a data-informed source distribution. Hierarchical flow matching models the full conditional velocity law in velocity space, but its inner flow is asked to transport isotropic Gaussian noise to a multimodal target velocity distribution from scratch. Our key observation is that this inner source can be replaced by a closed-form surrogate built from a coreset of the target. CCVFM first compresses the target into weighted atoms using an entropic Sinkhorn coreset and lifts them to a Gaussian mixture. The induced conditional velocity law is then a closed-form Gaussian mixture that can be sampled without a learned neural sampler. A lightweight correction flow, trained from this exact surrogate source, then refines the remaining surrogate-to-target residual rather than learning an entire noise-to-data map. We prove that the surrogate transport cost equals the target–surrogate Wasserstein gap under an explicit compression assumption, whereas the noise-source analogue has a dimension-scale lower bound. We further characterize the conditional second moment of the direct surrogate-source training target and show that its source-dependent excess is small when the surrogate conditional law is close to the true conditional velocity law in mean and covariance. Empirically, on MNIST, CIFAR-10, ImageNet-32, and CelebA-HQ, the proposed method reaches competitive few-step generation under matched architectures.
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Machine Learning (Statistics)

When Should an AI Workflow Release? Always-Valid Inference for Black-Box Generate-Verify Systems

LLM-enabled AI workflows increasingly produce outputs through iterative generate-evaluate-revise loops. Each iteration can improve the candidate, but it also creates a release decision: when to stop and output the current result? This raises a statistical challenge because deployment-time evaluator scores are adaptively generated and repeatedly monitored, yet the likelihood models or exchangeability assumptions typically used for calibration are unavailable. We propose an always-valid release wrapper for existing generator-evaluator pipelines. The wrapper builds a hard-negative reference pool of high-scoring failures, calibrates deployment-time evaluator scores against this pool, and accumulates the resulting evidence with an e-process. This separates two roles: the reference pool turns black-box scores into conservative evidence, while the e-process provides validity under optional stopping. In theory, we show that a conservative reference pool yields finite-sample control of the probability of releasing on infeasible tasks, that is, tasks for which the given workflow is not capable of producing a reliable solution. We also characterize conditions under which the same conservative rule still achieves nontrivial release on feasible tasks. In an MBPP+ coding-agent case study, the wrapper reduces premature incorrect release relative to baseline stopping rules while still releasing on tasks for which the workflow repeatedly accumulates moderate supporting evidence.
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Machine Learning (Statistics)

The Mechanism of Weak-to-Strong Generalization: Feature Elicitation from Latent Knowledge

Weak-to-strong (W2S) generalization, in which a strong model is fine-tuned on outputs of a weaker, task-specialized model, has been proposed as an approach to aligning superhuman AI systems. Existing theoretical analyses either fix the student's representations or operate in restricted settings. Whether multi-step SGD can succeed in feature learning while preserving diverse pre-trained capabilities remains open. We study W2S in the setting of reward-model learning with two-layer neural networks. The strong model has pre-trained representations organized into low-dimensional subspaces $V_k$, and is fine-tuned under the supervision of a weak model specialized on task $\kappa$. We prove that the strong model efficiently learns task $\kappa$, eliciting its pre-trained knowledge while retaining general capabilities. This establishes W2S generalization in the feature-learning regime, in the sense that the strong model acquires the target feature direction through W2S training, rather than having it given a priori. Moreover, W2S preserves pre-trained off-target features, whereas standard supervised fine-tuning causes catastrophic forgetting when off-target feature directions are correlated with the target's. Numerical experiments on synthetic data confirm our theoretical results.
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Statistical Methodology

A Bayesian Adaptive Latent Mixture Model for Zero-Inflated Weighted Brain Connectome Analysis

Replicated weighted networks often exhibit many structural zeros alongside heterogeneous non-zero edge strengths. In structural connectomics, this zero-inflation coincides with subjects expressing overlapping, rather than discrete, connectivity patterns. To address these features, we propose a Bayesian adaptive latent mixture model for zero-inflated weighted networks. Our approach represents each subject network as a simplex mixture of shared low-rank latent score matrices, integrated with a hurdle likelihood that separates edge existence from conditional edge strength. A sparsity-coupling parameter enables absent edges to be either independent of, or informative about, the latent connectivity. For computation, we employ transformed Hamiltonian Monte Carlo on unconstrained coordinates, selecting the number of templates via predictive fit, held-out link prediction, and template stability. Theoretically, we establish posterior consistency, local asymptotic normality, a Bernstein–von Mises approximation, and predictive consistency for an identifiable quotient-space estimand under a fixed-template scenario. Simulations demonstrate performance gains over topology-only baselines in settings with mixed memberships or structure-informed sparsity. Applied to Human Connectome Project data, the model recovers stable latent score patterns and heterogeneous subject-level mixtures, with behavioural analyses serving strictly as exploratory annotations rather than confirmatory biomarker claims.
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Machine Learning (Statistics)

Robust Sequential Experimental Design for A/B Testing

Experimental design has emerged as a powerful approach for improving the sample efficiency of A/B testing, yet existing designs rely critically on correctly specified models. We study robust sequential experimental design under model misspecification and develop a unified framework that covers both contextual bandit and dynamic settings. Theoretically, we prove that our design bounds the worst-case mean squared error of the estimated treatment effect. Empirically, we demonstrate the effectiveness of the proposed approach using synthetic and real-world datasets from a leading technology company.
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All authors Qianglin Wen, Xiangkun Wu, Chengchun Shi, Ting Li, Niansheng Tang, Yingying Zhang, Hongtu Zhu

Statistics Applications · Cross-listed from cs.LG

RISED: A Pre-Deployment Evaluation Framework for High-Stakes AI Decision-Support Systems, with Application to Healthcare

Clinical decision-support systems are expert systems whose recommendations clinicians act on directly, yet they are usually cleared on one aggregate accuracy number from a held-out test set. That number says nothing about input reliability under encoding shifts, subgroup gaps, threshold sensitivity, or operational feasibility. We present RISED, a pre-deployment evaluation framework operationalising five dimensions (Reliability, Inclusivity, Sensitivity, Equity, Deployability) through BCa bootstrap 95% confidence intervals, literature-grounded thresholds, and Holm-Bonferroni-corrected PASS / FAIL / INCONCLUSIVE verdicts; Equity is a proxy-dependence diagnostic rather than a gating test. Applied to seven cohorts spanning 35 years (n from 303 to 99,492), RISED surfaces failures invisible to AUROC: on Diabetes 130, Reliability passes by three orders of magnitude (PSS = 0.0004) while Inclusivity (AUC parity gap = 0.262) and Sensitivity (max threshold-flip rate 49.1%) fail decisively; both NHIS cohorts reproduce this. NHANES 2021-2023, with a complete feature profile, achieves INCONCLUSIVE verdicts; BRFSS 2024 produces the suite's most severe Sensitivity failure (max threshold-flip rate 64.2%) after instrument rotation removed hypertension and cholesterol. The pattern recurs on credit- and income-prediction cohorts, confirming domain-agnosticity; a multi-model check shows the failures are data-driven, not model-specific. RISED ships as an open-source Python package complementing TRIPOD+AI, FUTURE-AI, and Fairlearn with the structured numerical evidence those standards require but do not prescribe.
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All authors Rohith Reddy Bellibatlu, Manpreet Singh, Yash Jajoo, Shyamal Lakhanpal, Abhishek Israni

2605.12895 · 13 May · 39 pages, 7 figures, 15 tables. Code at https://github.com/rohithreddybc/rised-healthcare-eval and dataset at https://doi.org/10.57967/hf/8734 (Hugging Face). To be submitted to Expert Systems with Applications (Elsevier)

Statistics Applications

Steer-to-Detect: Probing Hidden Representations for Detection of LLM-Generated Texts

The rapid advancement of large language models (LLMs) has made machine-generated text increasingly difficult to distinguish from human-written text. While recent studies explore leveraging internal representations of language models to uncover deeper detection signals, these raw features often exhibit substantial overlap between classes, limiting their discriminative power. To address this challenge, we propose Steer-to-Detect (S2D), a two-stage framework for detecting LLM-generated text. In the first stage, S2D learns a steering vector that is injected into the hidden states of a frozen observer LLM, producing representations with improved class separability. In the second stage, detection is performed via a hypothesis testing procedure based on the steered representations. We establish finite-sample, high-probability guarantees for Type I and Type II errors, providing a theoretical characterization of the procedure. Empirically, S2D achieves strong and consistent performance across a range of settings, including out-of-distribution scenarios and adversarial perturbations.
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Statistical Methodology

Change-point detection in variance-covariance matrix

We consider the joint estimation of change-point locations and the sparsity pattern of the variance-covariance matrix, which is assumed to evolve in a piecewise constant manner. By applying Group Fused LASSO and LASSO penalties to the squared Frobenius norm, we estimate both the covariance structure and the change points. Adaptive weights are incorporated into the penalty terms to enhance change-point detection and covariance estimation accuracy. We establish the conditions under which the estimated change points and the sparse estimators within each segment are consistent. To solve the resulting optimization problem efficiently, we develop an alternating direction method of multipliers (ADMM) whose updates reduce to computationally tractable subproblems. The performance of the proposed method is illustrated through synthetic and real-data experiments, including comparisons with several competing procedures.
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Statistical Methodology

Never Too LATE: A Fully Stochastic Update to the Potential Outcome Framework

In the classic potential outcome framework, the local average treatment effect (LATE) and its identification via an instrumental variable are stated in a deterministic setting at the individual level: each individual has settled potential outcomes such as “cured if treated”. Several authors have proposed working instead with stochastic potential outcomes – counterfactual probabilities of the form “the chance of being cured if treated” – but the integration of stochastic potential outcomes with the LATE machinery raises an issue. It is a metaphysical issue: in a stochastic setting, the standard joint-probability definitions of compliers and the LATE assume what I will call the unique-parallel-universe view, which asserts that, in any genuinely possible state of the world, every counterfactual condition settles a unique determinate outcome even when the underlying causal disposition is irreducibly chancy. The statistician Dawid (2000) doubts the plausibility of this view; the philosopher Lewis (1973) develops a reductio argument against it. I propose a fully stochastic update to the Rubin causal model that drops the assumption of the unique-parallel-universe view: stochastic potential outcomes are introduced as Bernoulli parameters in their own (small) probability spaces, and are connected to observables via the factorization rule of a causal Bayes net. Within this framework, I define a Degree-of-compliance-weighted Average Treatment Effect (DATE) and prove that, under assumptions analogous to those used for the LATE but rewritten for the fully stochastic setting, the DATE equals the usual IV estimand. The classic LATE identification result emerges as a deterministic special case. Existing IV practice can therefore be reinterpreted: it has been estimating the DATE all along, in a general stochastic setting, without assuming the unique-parallel-universe view.
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Statistical Computation · Cross-listed from math.NA

Walk on spheres and Array-RQMC

We use Array-RQMC sampling in a walk on spheres (WoS) algorithm for Dirichlet boundary value problems. On a collection of problems, we find that Array-RQMC-WoS reduces the Monte Carlo MSE or variance by factors ranging from $71$-fold to $3087$-fold at $n=2^{17}$ trajectories. The variance is known to be $o(1/n)$ but attains empirical rates between $n^{-1.4}$ and $n^{-1.8}$ in our examples. A simpler RQMC-WoS algorithm studied in Ho and Owen (2026) has more theoretical support but only reduced variance by 1.8 to 10.7-fold on the same set of examples. In order to explain this improvement, we introduce a column-wise mean dimension of the RQMC error based on Sobol' indices. It matches the usual mean dimension for Monte Carlo and the mean dimension of a dual lattice error for randomized lattices. We find for a gasket example from Crane et al. (2025) that the mean dimension of Array-RQMC-WoS errors is much higher than an analogous Array-MC-WoS algorithm has. v2 replaced v1's QMCPy lattice with Korobov lattices from LatNet Builder, but left the old abstract in the meta-data v3 corrects the v2 abstract in this meta data
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Statistics Applications

Decision Support for Marketplace Policies under Incomplete Evidence: From Replay to Launch Readiness

Marketplace platforms routinely evaluate pricing and allocation policies using logged observational data, yet strong offline performance does not imply that a policy is safe to deploy. In real-time bidding (RTB) marketplaces, reserve-price and floor-policy changes affect not only revenue but also fill, advertiser value, budget pacing, and competition across auctions, creating feedback and interference. The central problem is therefore not to estimate whether a policy improves an offline metric, but to determine whether the available evidence justifies direct launch or only further validation. In this regard, we propose a support-aware decision-support system (DSS) that distinguishes promising from actionable evidence. The framework integrates replay, support-aware off-policy evaluation (OPE), conservative lower-bound ranking, multi-sided guardrails, out-of-time validation, sensitivity analysis, and interference-aware validation design into a claim-preserving pipeline that outputs a launch-readiness classification rather than a single performance estimate. Applying the framework to iPinYou-style RTB logs, we identify a margin-gated floor policy as the leading candidate, with a 47.7% replay yield lift, a 45.8% conservative lower-tail lift, and stable out-of-time performance. However, the framework does not recommend direct launch. A decision-rule ablation shows that simplified pipelines select the same policy but incorrectly recommend deployment, leaving key causal assumptions unresolved. In contrast, the proposed DSS selects the same policy but changes the action to online validation, reflecting missing evidence on propensities, bidder response, and interference. Overall, the contribution is a reproducible DSS protocol that prevents decision overclaim under partial identification and converts offline evaluation into an auditable, action-oriented recommendation.
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Tuesday 12 May

Statistics Applications

Digital Twins as Synthetic Controls in Single-Arm Trials

Single-arm trials are an important study design for evaluating drug efficacy and safety without enrolling patients into a control arm. Although they do not provide the gold-standard evidence of randomized controlled trials, they are increasingly used in clinical development as they offer an efficient, ethical, and practical alternative. A wide variety of approaches can be used to construct control comparators and estimate treatment effects, from fixed comparators informed by clinical knowledge to data-based and model-based patient-level comparators, also known as synthetic controls. Powerful and flexible machine learning models can allow outcome-model-based synthetic controls to overcome key limitations of direct data-based approaches, yield more robust estimates of treatment effects, and provide a principled way to incorporate corrections or encode additional assumptions when external data are not directly comparable. In this work, we argue that outcome-model-based synthetic control arms are an important tool for single-arm trials. We focus on digital twins, personalized predictions of disease progression generated from machine learning models trained on historical datasets, which naturally leverage these flexible approaches. We review doubly robust estimators, present power and sample size formulas, and discuss trade-offs in selecting historical data for training and analysis. We also outline practical considerations for deploying digital twins within the framework of recent FDA draft guidance on the use of artificial intelligence in drug development. Finally, we reanalyze data from trials in amyotrophic lateral sclerosis and Huntington's disease to demonstrate the proposed methods.
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All authors Daniele Bertolini, Franklin Fuller, Aaron M. Smith, Jonathan R. Walsh, Run Zhuang

Statistical Methodology

Linking COPD Prevalence with Income Distribution: A Spatial Heterogeneous Compositional Regression via Geographically Weighted Penalized Approach

Income inequality is a major contributor to health disparities, yet its effects often vary by geography and are commonly represented as compositional distributions (e.g., proportions of households across income brackets). Existing spatial regression methods struggle in this setting: they typically assume smooth spatial variation, cannot accommodate abrupt spatial heterogeneity, and lack principled treatment of compositional covariates. We propose a geographically weighted penalized compositional regression model that addresses these challenges simultaneously. Our method adopts a pairwise fusion penalty that enables detection of both contiguous and noncontiguous regional clusters with shared regression effects, thereby relaxing strong assumptions of spatial smoothness and geographic contiguity. This allows regions with similar underlying socioeconomic structures to be identified even when they are not geographically adjacent. By incorporating nonconvex penalties, such as the minimax concave penalty (MCP), the approach achieves improved estimation accuracy, interpretability, and scalability in high-dimensional spatial settings. We illustrate the method through an analysis linking U.S. income composition to chronic obstructive pulmonary disease (COPD) prevalence, revealing spatially heterogeneous associations that are obscured by conventional models. The proposed framework provides a flexible and robust tool for spatial data analysis involving compositional predictors and region-specific heterogeneity.
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All authors Jingwen Deng, Shujie Ma, Sergio J. Rey, Guanyu Hu

Statistical Computation

Multi-Marginal Couplings for Metropolis-Hastings

Convergence diagnosis for Markov chain Monte Carlo is a matter of fundamental importance in computational statistics: it determines the resources allocated to a particular sampling problem and influences the practitioner's view of the quality of estimates obtained from a Markov chain. Motivated by this, we contribute to the emerging class of coupling-based convergence diagnostic algorithms. Concretely, we study coupling multiple Metropolis-Hastings chains using multi-marginal coupling. We introduce a natural objective for this setting and establish lower and upper bounds by drawing connections to list-level distribution coupling and distributed pairwise-matching problems. This analysis ultimately leads to a shared-randomness Poisson Monte Carlo construction for coupling multiple Markov chains. In this process, we avoid a key dimension-dependent bottleneck in the runtime complexity of classical Poisson Monte Carlo by developing an adaptive rule for updating the point process, yielding significant gains in high-dimensional settings. Experiments on grand couplings of Markov chains show that our methods improve coalescence rates across dimensions, reducing meeting times by up to 50% compared with existing baselines.
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All authors Buu Phan, Gergely Flamich, Ashish Khisti, Shahab Asoodeh

Statistical Methodology

Evaluating the impact of outcome delay on the efficiency of sample size re-estimation

Sample size reestimation can be a powerful tool to ensure that a clinical trial meets its prespecified power requirements when uncertainty regarding a design parameter exists at the planning stage. However, long term primary endpoints can be harmful to the efficiency of this trial design. If recruitment is continued while treatment outcomes are awaited, long delay can potentially lead to a large number of pipeline participants being recruited in the trial that do not contribute to the interim analysis. This may lead to a larger number of recruited participants than are actually deemed required, resulting in an overpowered trial with high cost. This paper studies the exact impact of such outcome delay on the efficiency of internal pilot type SSR designs. The distribution of the final sample size post SSR is obtained under various delay lengths for both continuous and binary outcome data, how delay impacts the precision of the final sample size estimate is then discussed. Precisely, the impact of delay on this precision is assessed through RMSE, as well as two more novel metrics, termed the delay impact and cost. The results indicate that with increase in delay length, the delay impact increases, inflating average sample size and power. However, the severity of the effect of delayed outcomes depends highly on the exact trial setting. Trials where the reestimated sample size is smaller than originally planned suffer the most from delayed outcomes, often leading to an overpowered trial. However, the impact of delay is substantially less if the original planned sample size remains smaller than the reestimated sample size.
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Statistical Methodology

When to Trust Confidence Thresholding: Calibration Diagnostics for Pseudo-Labelled Regression

Calibrated probability outputs of trained classifiers are increasingly used as inputs to downstream regression estimands such as effects, prevalences, or disparities for a latent group observed only on a small labelled subset. A standard practice is to threshold the calibrated score at a confidence cutoff and treat the hard label as the truth. Building on a recent identification result for the underlying moment equation, we develop a calibration-aware diagnostic apparatus for pseudo-labelling pipelines. We derive a closed-form expression for the attenuation bias that confidence thresholding induces in the downstream regression coefficient, and show that the bias can be predicted, before any inference is run, from the residual score variance $V^{*}=\mathbb{E}[\operatorname{Var}(p\mid X)]$ on the unlabelled set after partialling out the downstream controls $X$. We further obtain a sharp sensitivity bound under bounded calibration drift, and identify the boundary $V^{*}=0$, which holds iff $p$ is a deterministic function of $X$; this motivates a structural separation between classifier features $W$ and downstream controls $X\subsetneq W$. Five controlled simulations and a UCI Adult illustration trace the predictions. The contribution is operational: a $(V^{*}, \kappa)$ decision rule that practitioners can compute from any classifier output to decide whether confidence thresholding is safe.
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Machine Learning (Statistics)

ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks

Open time-series forecasting (TSF) benchmarks cover retail, energy, weather, and traffic, but supply-chain logistics remains underserved. We introduce ISOMORPH, the first public digital twin of a multi-echelon logistics network with interpretable, user-configurable parameters and modular topology, demand, and control rules. The simulator advances a directed routing graph in discrete time: demand is served from inventory or recorded as backlog and triggers replenishment throughout the network. The state tracks inventory, outstanding orders, in-transit shipments, and a smoothed demand estimate, yielding Markovian dynamics on a tractable state space. The released data reproduces the bullwhip effect at empirically consistent magnitudes, while three conservation laws provide verification tools for simulator extensions. We release datasets at two catalogue scales ($C=50$ and $C=200$), with a 33-rollout scenario library at $C=50$. These datasets exhibit dynamics largely absent from fixed TSF benchmarks, including variance amplification, cascading bottlenecks, regime shifts, and cross-channel coupling through shared macro shocks. Zero-shot evaluation of three foundation models (Chronos, Moirai, TimesFM) against three in-domain-trained baselines (ARIMA, ETS, PatchTST) spans four targets: demand, backlog, fill rate, and edge utilization. Comparison with ETTh1, Electricity, and Weather shows that ISOMORPH introduces forecasting regimes that differ from standard real-world TSF benchmarks, positioning it as a complementary, regenerable logistics-domain benchmark. The same pairing produces forecast confidence bands across scenario configurations, providing forward UQ from parameter uncertainty and demonstrating foundation models as fast surrogates for digital-twin-based UQ. Code (MIT): https://github.com/tuhinsahai/ISOMORPH. Interactive demo: https://huggingface.co/spaces/HyeminGu/ISOMORPH-demo.
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All authors Zhizhen Zhang, Hyemin Gu, Benjamin J. Zhang, Daniel Elenius, Michael Tyrrell, Theo J. Bourdais, Houman Owhadi, Markos A. Katsoulakis, Tuhin Sahai

Machine Learning (Statistics) · Cross-listed from q-fin.MF

Yield Curves Dynamics Using Variational Autoencoders Under No-arbitrage

This paper introduces a physics-informed generative framework that resolves the fundamental conflict between the statistical flexibility of deep learning and the rigorous theoretical constraints of fixed-income modeling. We demonstrate that standard generative models and unconstrained statistical extrapolations suffer from "manifold collapse" and severe arbitrage violations when forecasting term structures across diverse macroeconomic regimes. To overcome this, we propose a two-stage architecture. First, a Student-t Conditional Variational Autoencoder with Dynamic Level Injection (CVAEsT+LS) extracts a robust, heavy-tailed term structure manifold, effectively decoupling macroeconomic shape dynamics from absolute base rates. Second, the latent dynamic evolution is governed by a continuous-time Neural Stochastic Differential Equation (SDE) strictly penalized by a No-Arbitrage Partial Differential Equation (PDE). Empirical results across multiple sovereign currencies (USD, GBP, JPY) confirm that our synergistic approach drastically reduces out-of-sample forecasting errors – achieving an exceptional 6.58 bps Mean Tenor RMSE – and successfully overcomes the massive parallel drift and zero-lower-bound violations exhibited by the classical HJM model in extreme environments. Furthermore, through phase space vector field analysis, we demonstrate the model's superior capability in unsupervised macroeconomic regime detection and high-quality continuous-time scenario generation. Ultimately, this research provides a highly scalable, mathematically sound evolutionary engine for term structure modeling.
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Statistical Methodology

How long should a block be?

The block maximum method, which is widely used in extreme value analysis, uses a generalized extreme value distribution to approximate that of the maximum of m observations. The quality of this approximation depends on the value of m and may be poor if m is too small. Surprisingly little attention has been paid to the choice of the block length, although a good choice is crucial to the success of the method. In this paper we assess the effect of taking excessively long blocks in terms of asymptotic relative efficiency, and propose likelihood-based approaches and graphical diagnostics to determine whether a proposed block length is suitable, allowing for potential rounding and left-censoring of observations. We investigate our ideas using simulation and illustrate them using wind speed, river flow and rainfall data.
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Machine Learning (Statistics) · Cross-listed from math.OC

Uncovering Symmetry Transfer in Large Language Models via Layer-Peeled Optimization

Large language models (LLMs) are pretrained by minimizing the cross-entropy loss for next-token prediction. In this paper, we study whether this optimization strategy can induce geometric structure in the learned model weights and context embeddings. We approach this problem by analyzing a constrained layer-peeled optimization program, which serves as a mathematically tractable surrogate for LLMs by treating the output projection matrix and last-layer context embeddings as optimization variables. Our analysis of this nonconvex optimization program demonstrates that symmetries in the target next-token distributions are transferred to the global minimizers of the layer-peeled model in a precise group-theoretic sense. Specifically, we prove that when the target tokens exhibit a cyclic-shift symmetry (such as the seven days of the week or the twelve months of the year), the optimal logit matrix is exactly circulant, and the Gram matrices of both the output projections and the context embeddings form circulant geometries as well. Next, for exchangeable target distributions invariant under the symmetric group and, more generally, under two-transitive group actions, we show that the global optimal output projection matrix forms a simplex equiangular tight frame, while the optimal logit matrix and context embeddings inherit the permutation symmetries present in the input data. A key technical step is to reduce the constrained nonconvex factorized problem to an explicit logit-level convex characterization for cyclic symmetry and to a symmetry-based lower bound for permutation symmetry, together with a sharp characterization of the optimal factorization. Finally, we empirically demonstrate that open-source LLMs naturally exhibit symmetries consistent with our theoretical predictions, despite being trained without any explicit regularization promoting such geometric structure.
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Machine Learning (Statistics) · Cross-listed from cs.LG

From Generalist to Specialist Representation

Given a generalist model, learning a task-relevant specialist representation is fundamental for downstream applications. Identifiability, the asymptotic guarantee of recovering the ground-truth representation, is critical because it sets the ultimate limit of any model, even with infinite data and computation. We study this problem in a completely nonparametric setting, without relying on interventions, parametric forms, or structural constraints. We first prove that the structure between time steps and tasks is identifiable in a fully unsupervised manner, even when sequences lack strict temporal dependence and may exhibit disconnections, and task assignments can follow arbitrarily complex and interleaving structures. We then prove that, within each time step, the task-relevant latent representation can be disentangled from the irrelevant part under a simple sparsity regularization, without any additional information or parametric constraints. Together, these results establish a hierarchical foundation: task structure is identifiable across time steps, and task-relevant latent representations are identifiable within each step. To our knowledge, each result provides a first general nonparametric identifiability guarantee, and together they mark a step toward provably moving from generalist to specialist models.
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All authors Yujia Zheng, Fan Feng, Yuke Li, Shaoan Xie, Kevin Murphy, Kun Zhang

Statistics Theory

Optimal sequential tests yield log-optimal e-processes

It has been recently shown that e-processes are sufficient for sequential testing in the following sense: every level-$\alpha$ sequential test can be obtained by thresholding an e-process at $1/\alpha$. However, in the above result, neither does the test have to be asymptotically optimal (in terms of stopping times) nor does the e-process have to be asymptotically log-optimal. It has separately been shown that asymptotically log-optimal e-processes yield asymptotically optimal sequential tests. In this paper, we prove the converse, arguably completing the story: it is possible to aggregate asymptotically optimal sequential tests into asymptotically log-optimal e-processes. This is accomplished by using a new class of WAIT e-processes: those that are Weighted Aggregates of Indicators of stopping Times that begin at zero, are nondecreasing and increase to infinity under the alternative at the optimal rate. Importantly, the paper discusses several nuances in the varied definitions of asymptotic (log-)optimality.
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Machine Learning (Statistics)

A Unified Framework for Critical Scaling of Inverse Temperature in Self-Attention

Length-dependent logit rescaling is widely used to stabilize long-context self-attention, but existing analyses and methods suggest conflicting inverse-temperature laws for the context length $n$, ranging from $(\log n)^{1/2}$ to $\log n$ and $(\log n)^2$. We provide a general theory showing that the desirable scale is determined by the gap-counting function $N_n$ of each attention row. Counting how many competitors lie within each gap from the maximum, we define an upper-tail accumulation scale and prove that it gives the critical inverse-temperature scale for softmax concentration: below this scale, the top competitors remain unseparated, whereas above it, the attention entropy collapses. This framework unifies prior scaling laws as different $N_n$ and yields a direct diagnostic for attention-score families, from idealized theoretical models to more practical transformers.
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