Papers

It is known that the minimum-mean-squared-error (MMSE) denoiser under Gaussian noise can be written as a proximal operator, which suffices for asymptotic convergence of plug-and-play (PnP) methods but does not reveal the structure of the induced regularizer or give convergence rates. We show that the MMSE denoiser corresponds to a regularizer that can be written explicitly as an upper Moreau envelope of the negative log-marginal density, which in turn implies that the regularizer is 1-weakly convex. Using this property, we derive (to the best of our knowledge) the first sublinear convergence guarantee for PnP proximal gradient descent with an MMSE denoiser. We validate the theory with a one-dimensional synthetic study that recovers the implicit regularizer. We also validate the theory with imaging experiments (deblurring and computed tomography), which exhibit the predicted sublinear behavior.

Guided Source Separation (GSS) is a popular front-end for distant automatic speech recognition (ASR) systems using spatially distributed microphones. When considering spatially distributed microphones, the choice of reference microphone may have a large influence on the quality of the output signal and the downstream ASR performance. In GSS-based speech enhancement, reference microphone selection is typically performed using the signal-to-noise ratio (SNR), which is optimal for noise reduction but may neglect differences in early-to-late-reverberant ratio (ELR) across microphones. In this paper, we propose two reference microphone selection methods for GSS-based speech enhancement that are based on the normalized $\ell_p$-norm, either using only the normalized $\ell_p$-norm or combining the normalized $\ell_p$-norm and the SNR to account for both differences in SNR and ELR across microphones. Experimental evaluation using a CHiME-8 distant ASR system shows that the proposed $\ell_p$-norm-based methods outperform the baseline method, reducing the macro-average word error rate.

Integrated sensing and communication (ISAC) is a key feature of next-generation wireless networks, enabling a wide range of emerging applications such as vehicle-to-everything (V2X) and unmanned aerial vehicles (UAVs), which operate in high-mobility scenarios. Notably, the wireless channels within these applications typically exhibit severe delay and Doppler spreads. The latter causes serious communication performance degradation in the Orthogonal Frequency-Division Multiplexing (OFDM) waveform that is widely adopted in current wireless networks. To address this challenge, the recently proposed Doppler-resilient affine frequency division multiplexing (AFDM) waveform, which uses flexible chirp signals as subcarriers, shows great potential for achieving adaptive ISAC in high-mobility scenarios. This article provides a comprehensive overview of AFDM-ISAC. We begin by presenting the fundamentals of AFDM-ISAC, highlighting its inherent frequency-modulated continuous-wave (FMCW)-like characteristics. Then, we explore its ISAC performance limits by analyzing its diversity order, ambiguity function (AF), and Cramer-Rao Bound (CRB). Finally, we present several effective sensing algorithms and opportunities for AFDM-ISAC, with the aim of sparking new ideas in this emerging field.

This paper presents a physics-informed machine learning approach for synthesizing optimal feedback control policy for infinite-horizon optimal control problems by solving the Hamilton-Jacobi-Bellman (HJB) partial differential equation(PDE). The optimal control policy is derived analytically for affine dynamical systems with separable and strictly convex control costs, expressed as a function of the gradient of the value function. The resulting HJB-PDE is then solved by approximating the value function using the Extreme Theory of Functional Connections (X-TFC) - a hybrid approach that combines the Theory of Functional Connections (TFC) with the Extreme Learning Machine (ELM) algorithm. This approach ensures analytical satisfaction of boundary conditions and significantly reduces training cost compared to traditional Physics-Informed Neural Networks (PINNs). We benchmark the method on linear and non-linear systems with known analytical solutions as well as demonstrate its effectiveness on control tasks such as spacecraft optimal de-tumbling control.

This paper proposes a novel beamforming framework in the reproducing kernel domain, derived from a unified interpretation of directional response as spatial differentiation of the sound field. By representing directional response using polynomial differential operators, the proposed method enables the formulation of arbitrary beam patterns including non-axisymmetric. The derivation of the reproducing kernel associated with the interior fields is mathematically supported by Hobson's theorem, which allows concise analytical expressions. Furthermore, the proposed framework generalizes conventional spherical harmonic domain beamformers by reinterpreting them as spatial differential operators, thereby clarifying their theoretical structure and extensibility. Three numerical simulations conducted in two-dimensional space confirm the validity of the method.

In this paper, we address the problem of reconstructing multiband signals from modulo-folded, pointwise samples within the Unlimited Sensing Framework (USF). Focusing on a low-complexity, single-channel acquisition setup, we establish recovery guarantees demonstrating that sub-Nyquist sampling is achievable under the USF paradigm. In doing so, we also tighten the previous sampling theorem for bandpass signals. Our recovery algorithm demonstrates up to a 13x dynamic range improvement in hardware experiments with up to 6 spectral bands. These results enable practical high-dynamic-range multiband acquisition in scenarios previously limited by dynamic range and excessive oversampling.

Massive message transmissions, unpredictable aperiodic messages, and high-speed moving vehicles contribute to the complex wireless environment, resulting in inefficient resource collisions in Vehicle to Everything (V2X). In order to achieve better medium access control (MAC) layer performance, 3GPP introduced several new features in NR-V2X. One of the most important is the re-evaluation mechanism. It allows the vehicle to continuously sense resources before message transmission to avoid resource collisions. So far, only a few articles have studied the re-evaluation mechanism of NR-V2X, and they mainly focus on network simulator that do not consider variable traffic, which makes analysis and comparison difficult. In this paper, an analytical model of NR-V2X Mode 2 is established, and a message generator is constructed by using discrete time Markov chain (DTMC) to simulate the traffic pattern recommended by 3GPP advanced V2X services. Our study shows that the re-evaluation mechanism improves the reliability of NR-V2X transmission, but there are still local improvements needed to reduce latency.

Text-to-audio models are a type of generative model that produces audio output in response to a given textual prompt. Although level generators and the properties of the functional content that they create (e.g., playability) dominate most discourse in procedurally generated content (PCG), games that emotionally resonate with players tend to weave together a range of creative and multimodal content (e.g., music, sounds, visuals, narrative tone), and multimodal models have begun seeing at least experimental use for this purpose. However, it remains unclear what exactly such models generate, and with what degree of variability and fidelity: audio is an extremely broad class of output for a generative system to target. Within the PCG community, expressive range analysis (ERA) has been used as a quantitative way to characterize generators' output space, especially for level generators. This paper adapts ERA to text-to-audio models, making the analysis tractable by looking at the expressive range of outputs for specific, fixed prompts. Experiments are conducted by prompting the models with several standardized prompts derived from the Environmental Sound Classification (ESC-50) dataset. The resulting audio is analyzed along key acoustic dimensions (e.g., pitch, loudness, and timbre). More broadly, this paper offers a framework for ERA-based exploratory evaluation of generative audio models.

Aggregating intracranial recordings across subjects is challenging since electrode count, placement, and covered regions vary widely. Spatial normalization methods like MNI coordinates offer a shared anatomical reference, but often fail to capture true functional similarity, particularly when localization is imprecise; even at matched anatomical coordinates, the targeted brain region and underlying neural dynamics can differ substantially between individuals. We propose a scalable representation-learning framework that (i) learns a subject-agnostic functional identity for each electrode from multi-region local field potentials using a Siamese encoder with contrastive objectives, inducing an embedding geometry that is locality-sensitive to region-specific neural signatures, and (ii) tokenizes these embeddings for a transformer that models inter-regional relationships with a variable number of channels. We evaluate this framework on a 20-subject dataset spanning basal ganglia-thalamic regions collected during flexible rest/movement recording sessions with heterogeneous electrode layouts. The learned functional space supports accurate within-subject discrimination and forms clear, region-consistent clusters; it transfers zero-shot to unseen channels. The transformer, operating on functional tokens without subject-specific heads or supervision, captures cross-region dependencies and enables reconstruction of masked channels, providing a subject-agnostic backbone for downstream decoding. Together, these results indicate a path toward large-scale, cross-subject aggregation and pretraining for intracranial neural data where strict task structure and uniform sensor placement are unavailable.

Protecting passive radio astronomy observatories from unintended radio-frequency interference (RFI) is increasingly challenging as wireless activity expands near protected bands. While radio quiet zones, database-driven coordination, and post-processing mitigation can reduce interference risk, they often lack the ability to attribute detected RFI to a specific transmitter, particularly in low signal-to-noise ratio (SNR) regimes where conventional demodulation is infeasible. This paper presents the first over-the-air field demonstration of Pseudonymetry at the Owens Valley Radio Observatory (OVRO), evaluating an accountable coexistence approach between heterogeneous systems: an SDR-based narrowband OFDM transmitter and a wideband radio telescope backend. The transmitter embeds a pseudonym watermark on a dedicated OFDM subcarrier using coded power modulation, while OVRO passively extracts the watermark from standard backend spectrogram (power) products without IQ access. We develop a spectrogram-only receiver that performs correlation-based packet alignment, compensates timing resolution mismatch via resampling, and decodes pseudonym bits using energy-domain template matching. Field results across -20 to -5 dB SNR show that pseudonym watermarks can be recovered at low SNR, enabling practical transmitter attribution using only passive backend measurements. These findings suggest that observatories can support lightweight accountability mechanisms that complement dynamic protection and enforcement-oriented spectrum sharing frameworks.

Cell-free massive multiple-input multiple-output (MIMO) is a key technology for next-generation wireless systems. The integration of cell-free massive MIMO within the open radio access network (O-RAN) architecture addresses the growing need for decentralized, scalable, and high-capacity networks that can support different use cases. Precoding is a crucial step in the operation of cell-free massive MIMO, where O-RUs steer their beams towards the intended users while mitigating interference to other users. Current precoding schemes for cell-free massive MIMO are either fully centralized or fully distributed. Centralized schemes are not scalable, whereas distributed schemes may lead to a high inter-O-RU interference. In this paper, we propose a distributed and scalable precoding framework for cell-free massive MIMO that uses limited information exchange among precoding agents to mitigate interference. We formulate an optimization problem for precoding that maximizes the aggregate throughput while guaranteeing the minimum data rate requirements of users. The formulated problem is nonconvex. We propose a multi-timescale framework that combines multi-agent deep reinforcement learning (DRL) with expert insights from an iterative algorithm to determine the precoding matrices efficiently. We conduct simulations and compare the proposed framework with the centralized precoding and distributed precoding methods for different numbers of O-RUs, users, and transmit antennas. The results show that the proposed framework achieves a higher aggregate throughput than the distributed regularized zero-forcing (D-RZF) scheme and the weighted minimum mean square error (WMMSE) algorithm. When compared with the centralized regularized zero-forcing (C-RZF) scheme, the proposed framework achieves similar aggregate throughput performance but with a lower signaling overhead.

The response-only model class selection capability of a novel deep convolutional neural network method is examined herein in a simple, yet effective, manner. Specifically, the responses from a unique degree of freedom along with their class information train and validate a one-dimensional convolutional neural network. In doing so, the network selects the model class of new and unlabeled signals without the need of the system input information, or full system identification. An optional physics-based algorithm enhancement is also examined using the Kalman filter to fuse the system response signals using the kinematics constraints of the acceleration and displacement data. Importantly, the method is shown to select the model class in slight signal variations attributed to the damping behavior or hysteresis behavior on both linear and nonlinear dynamic systems, as well as on a 3D building finite element model, providing a powerful tool for structural health monitoring applications.

Modern manufacturing demands high flexibility and reconfigurability to adapt to dynamic production needs. Model-based Engineering (MBE) supports rapid production line design, but final reconfiguration requires simulations and validation. Digital Twins (DTs) streamline this process by enabling real-time monitoring, simulation, and reconfiguration. This paper presents a novel platform that automates DT generation and deployment using AutomationML-based factory plans. The platform closes the loop with a GAI-powered simulation scenario generator and automatic physical line reconfiguration, enhancing efficiency and adaptability in manufacturing.

The evolution of electric vehicles (EVs) is reshaping the automotive industry, advocating for more sustainable transportation practices. Accurately predicting EV charging behavior is essential for effective infrastructure planning and optimization. However, the charging load of EVs is significantly influenced by uncertainties and randomness, posing challenges for accurate estimation. Furthermore, existing literature reviews lack a systematic analysis of modeling approaches focused on information fusion. This paper comprehensively reviews EV charging load models from the past five years. We categorize state-of-the-art modeling methods into statistical, simulated, and data-driven approaches, examining the advantages and drawbacks of each. Additionally, we analyze the three bottom-up level operations of information fusion in existing models. We conclude by discussing the challenges and opportunities in the field, offering guidance for future research endeavors to advance our understanding and explore practical research directions.

Spectral Graph Neural Networks (GNNs) have achieved state-of-the-art results by defining graph convolutions in the spectral domain. A common approach, popularized by ChebyNet, is to use polynomial filters based on continuous orthogonal polynomials (e.g., Chebyshev). This creates a theoretical disconnect, as these continuous-domain filters are applied to inherently discrete graph structures. We hypothesize this mismatch can lead to suboptimal performance and fragility to hyperparameter settings. In this paper, we introduce MeixnerNet, a novel spectral GNN architecture that employs discrete orthogonal polynomials – specifically, the Meixner polynomials $M_k(x; \beta, c)$. Our model makes the two key shape parameters of the polynomial, beta and c, learnable, allowing the filter to adapt its polynomial basis to the specific spectral properties of a given graph. We overcome the significant numerical instability of these polynomials by introducing a novel stabilization technique that combines Laplacian scaling with per-basis LayerNorm. We demonstrate experimentally that MeixnerNet achieves competitive-to-superior performance against the strong ChebyNet baseline at the optimal K = 2 setting (winning on 2 out of 3 benchmarks). More critically, we show that MeixnerNet is exceptionally robust to variations in the polynomial degree K, a hyperparameter to which ChebyNet proves to be highly fragile, collapsing in performance where MeixnerNet remains stable.

The dynamic structural load identification capabilities of the gated recurrent unit, long short-term memory, and convolutional neural networks are examined herein. The examination is on realistic small dataset training conditions and on a comparative view to the physics-based residual Kalman filter (RKF). The dynamic load identification suffers from the uncertainty related to obtaining poor predictions when in civil engineering applications only a low number of tests are performed or are available, or when the structural model is unidentifiable. In considering the methods, first, a simulated structure is investigated under a shaker excitation at the top floor. Second, a building in California is investigated under seismic base excitation, which results in loading for all degrees of freedom. Finally, the International Association for Structural Control-American Society of Civil Engineers (IASC-ASCE) structural health monitoring benchmark problem is examined for impact and instant loading conditions. Importantly, the methods are shown to outperform each other on different loading scenarios, while the RKF is shown to outperform the networks in physically parametrized identifiable cases.

The optimization-based damage detection and damage state digital twinning capabilities are examined here of a novel conditional-labeled generative adversarial network methodology. The framework outperforms current approaches for fault anomaly detection as no prior information is required for the health state of the system: a topic of high significance for real-world applications. Specifically, current artificial intelligence-based digital twinning approaches suffer from the uncertainty related to obtaining poor predictions when a low number of measurements is available, physics knowledge is missing, or when the damage state is unknown. To this end, an unsupervised framework is examined and validated rigorously on the benchmark structural health monitoring measurements of Z24 Bridge: a post-tensioned concrete highway bridge in Switzerland. In implementing the approach, firstly, different same damage-level measurements are used as inputs, while the model is forced to converge conditionally to two different damage states. Secondly, the process is repeated for a different group of measurements. Finally, the convergence scores are compared to identify which one belongs to a different damage state. The process for both healthy-to-healthy and damage-to-healthy input data creates, simultaneously, measurements for digital twinning purposes at different damage states, capable of pattern recognition and machine learning data generation. Further to this process, a support vector machine classifier and a principal component analysis procedure is developed to assess the generated and real measurements of each damage category, serving as a secondary new dynamics learning indicator in damage scenarios. Importantly, the approach is shown to capture accurately damage over healthy measurements, providing a powerful tool for vibration-based system-level monitoring and scalable infrastructure resilience.

Robotic systems have become integral to smart environments, enabling applications ranging from urban surveillance and automated agriculture to industrial automation. However, their effective operation in dynamic settings - such as smart cities and precision farming - is challenged by continuously evolving topographies and environmental conditions. Traditional control systems often struggle to adapt quickly, leading to inefficiencies or operational failures. To address this limitation, we propose a novel framework for autonomous and dynamic reconfiguration of robotic controllers using Digital Twin technology. Our approach leverages a virtual replica of the robot's operational environment to simulate and optimize movement trajectories in response to real-world changes. By recalculating paths and control parameters in the Digital Twin and deploying the updated code to the physical robot, our method ensures rapid and reliable adaptation without manual intervention. This work advances the integration of Digital Twins in robotics, offering a scalable solution for enhancing autonomy in smart, dynamic environments.

In this paper, we propose a novel blind multi-input multi-output (MIMO) semantic communication (SC) framework named Blind-MIMOSC that consists of a deep joint source-channel coding (DJSCC) transmitter and a diffusion-based blind receiver. The DJSCC transmitter aims to compress and map the source data into the transmitted signal by exploiting the structural characteristics of the source data, while the diffusion-based blind receiver employs a parallel variational diffusion (PVD) model to simultaneously recover the channel and the source data from the received signal without using any pilots. The PVD model leverages two pre-trained score networks to characterize the prior information of the channel and the source data, operating in a plug-and-play manner during inference. This design allows only the affected network to be retrained when channel conditions or source datasets change, avoiding the complicated full-network retraining required by end-to-end methods. This work presents the first fully pilot-free solution for joint channel estimation and source recovery in block-fading MIMO systems. Extensive experiments show that Blind-MIMOSC with PVD achieves superior channel and source recovery accuracy compared to state-of-the-art approaches, with drastically reduced channel bandwidth ratio.

Multimodal approaches that integrate protein structure and sequence have achieved remarkable success in protein-protein interface prediction. However, extending these methods to protein-peptide interactions remains challenging due to the inherent conformational flexibility of peptides and the limited availability of structural data that hinder direct training of structure-aware models. To address these limitations, we introduce GeoPep, a novel framework for peptide binding site prediction that leverages transfer learning from ESM3, a multimodal protein foundation model. GeoPep fine-tunes ESM3's rich pre-learned representations from protein-protein binding to address the limited availability of protein-peptide binding data. The fine-tuned model is further integrated with a parameter-efficient neural network architecture capable of learning complex patterns from sparse data. Furthermore, the model is trained using distance-based loss functions that exploit 3D structural information to enhance binding site prediction. Comprehensive evaluations demonstrate that GeoPep significantly outperforms existing methods in protein-peptide binding site prediction by effectively capturing sparse and heterogeneous binding patterns.

The global agricultural sector is undergoing a transformative shift, driven by increasing food demands, climate variability and the need for sustainable practices. SUSTAINABLE is a smart farming platform designed to integrate IoT, AI, satellite imaging, and role-based task orchestration to enable efficient, traceable, and sustainable agriculture with a pilot usecase in viticulture. This paper explores current smart agriculture solutions, presents a comparative evaluation, and introduces SUSTAINABLE's key features, including satellite index integration, real-time environmental data, and role-aware task management tailored to Mediterranean vineyards.

This paper presents an in-depth analysis of timing closure challenges and constraints in Field Programmable Gate Arrays (FPGAs) and Application Specific Integrated Circuits (ASICs). We examine core timing principles, architectural distinctions, and design methodologies influencing timing behavior in both technologies. A case study comparing the Xilinx Kintex UltraScale+ FPGA (XCKU040) with a 7nm ASIC highlights practical timing analysis and performance trade-offs. Experimental results show ASICs achieve superior timing of 45ps setup and 35ps hold, while modern FPGAs remain competitive with 180ps setup and 120ps hold times, validating their suitability for high-performance designs.

This work introduces a novel dispatchable current source virtual oscillator control (dCVOC) scheme for grid-following (GFL) converters, which exhibits duality with dispatchable virtual oscillator control (dVOC) in two ways: a) the current frequency is generated through reactive power control, similar to a PLL ; b) the current magnitude reference is generated through active power control. We formally prove that our proposed control always admits a steady-state equilibrium and ensures global stability under reasonable conditions on grid and converter parameters, even when considering LVRT and current saturation constraints. Our approach avoids low-voltage transients and weak grid instability, which is not the case for conventional GFL control. The effectiveness of our proposed control is verified through high-fidelity electromagnetic transient simulations.

With the development of renewable energy sources, power systems are gradually evolving into a system comprising both grid-forming (GFM) and grid-following (GFL) converters. However, the dynamic interaction between the two types of converters, especially low-inertia GFM converters and GFL converters, remains unclear due to the substantial differences in their synchronization mechanisms. To address this gap, this paper develops a small-signal synchronous stability model for power systems containing GFM and GFL converters, which considers network line dynamics. Based on subspace perturbation theory, we reveal that GFM and GFL subsystems can be effectively decoupled when GFL converters operate near unity power factor or when GFM converters possess sufficiently large inertia or damping, and provide lower bound of control parameters ensuring decoupling. Under the decoupling condition, we propose decentralized and analytical parameter-based stability criteria which have clear physical interpretations: the positive damping of converters compensates for the negative damping of the network. In the case of coupling, we also propose decentralized stability criteria based on the small phase theorem. The effectiveness of the theoretical analysis is validated through simulations in MATLAB/Simulink.

Automatic segmentation of diverse heterogeneous brain lesions using multi-modal MRI is a challenging problem in clinical neuroimaging, mainly because of the lack of generalizability and high prediction variance of pathology-specific deep learning models. In this work, we propose a unified and adaptive multi-stream framework called SYNAPSE-Net to perform robust multi-pathology segmentation with reduced performance variance. The framework is based on multi-stream convolutional encoders with global context modeling and a cross-modal attention fusion strategy to ensure stable and effective multi-modal feature integration. It also employs a variance-aware training strategy to enhance the robustness of the network across diverse tasks. The framework is extensively validated using three public challenge datasets: WMH MICCAI 2017, ISLES 2022, and BraTS 2020. The results show consistent improvements in boundary accuracy, delineation quality, and stability across diverse pathologies. This proposed framework achieved a high Dice similarity coefficient (DSC) of 0.831 and a low Hausdorff distance at the 95th percentile (HD95) of 3.03 on the WMH MICCAI 2017 dataset. It also achieved the lowest HD95 of 9.69 on the ISLES 2022 dataset and the highest tumor core DSC of 0.8651 on the BraTS 2020 dataset. These results validate the robustness of the proposed framework in providing a clinically relevant computer-aided solution for automated brain lesion segmentation. Source code and pretrained models are publicly available at https://github.com/mubid-01/SYNAPSE-Net-pre.

Integrated energy systems (IES) are complex heterogeneous architectures that typically encompass power sources, hydrogen electrolyzers, energy storage, and heat exchangers. This integration is achieved through operating control strategy optimization. However, the lack of physical understanding as to how these systems evolve over time introduces uncertainties that hinder reliable application thereof. Techniques that can accommodate such uncertainties are fundamental for ensuring proper operation of these systems. Unfortunately, no unifying methodology exists for accommodating uncertainties in this regard. That being said, adaptive control (AC) is a discipline that may allow for accommodating such uncertainties in real-time. In the present work, we derive an AC formulation for linear systems in which all states are observable and apply it to the control of a glycol heat exchanger (GHX) in an IES. Based on prior research in which we quantified the uncertainties of the GHXs system dynamics, we introduced an error of 50% on four terms of the nominal model. In the case where a linear quadratic regulator is used as the nominal control for the reference system, we found that employing AC can reduce the mean absolute error and integral time absolute error by a factor of 30%-75%. This reduction is achieved with minimal computing overhead and control infrastructure, thus underscoring the strength of AC. However, the control effort induced is significant, therefore warranting further study in order to estimate its impact on a physical system. To address further challenges, including partially observable and non-linear dynamics, enhancements of the linear formulation are currently being developed.

Grid-forming (GFM) technology is widely regarded as a promising solution for future power systems dominated by power electronics. However, a precise method for quantifying GFM converter behavior and a universally accepted GFM definition remain elusive. Moreover, the impact of GFM on system stability is not precisely quantified, creating a significant disconnect between device and system levels. To address these gaps from a small-signal perspective, at the device level, we introduce a novel metric, the Forming Index (FI) to quantify a converter's response to grid voltage fluctuations. Rather than enumerating various control architectures, the FI provides a metric for the converter's GFM ability by quantifying its sensitivity to grid variations. At the system level, we propose a new quantitative measure of system strength that captures the multi-bus voltage stiffness, which quantifies the voltage and phase angle responses of multiple buses to current or power disturbances. We further extend and define this concept to grid strength and bus strength to identify weak areas within the system. Finally, we bridge the device and system levels by formally proving that GFM converters enhance system strength. Our proposed framework provides a unified benchmark for GFM converter design, optimal placement, and system stability assessment.

Ferrohydrodynamic microfluidics relies on magnetic field gradients to manipulate diamagnetic particles in ferrofluid-filled microenvironments. It has emerged as a promising tool for label-free manipulation of bioparticles, including their separation and phenotyping. This perspective reviews recent progress in the development and applications of ferrofluid-based microfluidic platforms for multiscale bioparticle separation, ranging from micron-scale cells to submicron extracellular vesicles. We highlight the fundamental physical principles for ferrohydrodynamic manipulation, including the dominant magnetic buoyancy force resulting from the interaction of ferrofluids and particles. We then describe how these principles enable high-resolution size-based bioparticle separation, subcellular bioparticle enrichment, and phenotypic screening based on physical traits. We also discuss key challenges in ferrohydrodynamic microfluidics from the aspects of ferrofluid biocompatibility, system throughput, and nanoparticle depletion. Finally, we outline future research directions involving machine learning, 3D printing, and multiplexed detection. These insights chart a path for advancing ferrofluid-based technologies in precision biomedicine, diagnostics, and cellular engineering.

This paper proposes a cooperative integrated estimation-guidance framework for simultaneous interception of a non-maneuvering target using a team of unmanned autonomous vehicles, assuming only a subset of vehicles are equipped with dedicated sensors to measure the target's states. Unlike earlier approaches that focus solely on either estimation or guidance design, the proposed framework unifies both within a cooperative architecture. To circumvent the limitation posed by heterogeneity in target observability, sensorless vehicles estimate the target's state by leveraging information exchanged with neighboring agents over a directed communication topology through a prescribed-time observer. The proposed approach employs true proportional navigation guidance (TPNG), which uses an exact time-to-go formulation and is applicable across a wide spectrum of target motions. Furthermore, prescribed-time observer and controller are employed to achieve convergence to true target's state and consensus in time-to-go within set predefined times, respectively. Simulations demonstrate the effectiveness of the proposed framework under various engagement scenarios.

Multisine excitations are widely used for identifying multi-input multi-output systems due to their periodicity, data compression properties, and control over the input spectrum. Despite their popularity, the finite sample statistical properties of frequency-domain estimators under multisine excitation, for both nonparametric and parametric settings, remain insufficiently understood. This paper develops a finite-sample statistical framework for least-squares estimation of the frequency response function (FRF) and its implications for parametric modeling. First, we derive exact distributional and covariance properties of the FRF estimator, explicitly accounting for aliasing effects under slow sampling regimes, and establish conditions for unbiasedness, uncorrelatedness, and consistency across multiple experiments. Second, we show that the FRF estimate is a sufficient statistic for any parametric model under Gaussian noise, leading to an exact equivalence between optimal two stage frequency-domain methods and time-domain prediction error and maximum likelihood estimation. This equivalence is shown to yield finite-sample concentration bounds for parametric maximum likelihood estimators, enabling rigorous uncertainty quantification, and closed-form prediction error method estimators without iterative optimization. The theoretical results are demonstrated in a representative case study.