Statistical Methodology
Exact Comparison of Explanatory Strength of Two Dependent Predictors
Tomáš Mrkvička and Jan Radimský
Comparing the relative explanatory power of two dependent predictors regarding a common target variable is a fundamental challenge across scientific disciplines. Classical asymptotic procedures, such as Vuong's closeness test or the Hotelling-Williams test, frequently collapse under pathological data conditions, including heavy-tailed distributions and extreme categorical sparsity. To bypass these limitations, practitioners often turn to non-parametric resampling. However, naive permutation tests destroy the natural covariance structure of dependent predictors, while the paired bootstrap evaluating variance around the alternative hypothesis and introducing artificial ties suffers from metric space compression and categorical omission, rendering it highly unreliable in finite samples. In this paper, we introduce the Paired Swap Permutation Test, a novel and exact non-parametric methodology. Grounded in the principle of functional exchangeability under the null hypothesis, our
algorithm utilizes a symmetric within-subject swapping mechanism for categorical data, and introduces an Empirical Cumulative Distribution Function (ECDF) mapping step for continuous domains. This copula-based transposition perfectly preserves marginal densities and the empirical support without introducing resampling ties. Through extensive Monte Carlo simulations, we demonstrate that the proposed test strictly maintains the nominal significance level and maximizes statistical power under conditions where standard methods become catastrophically liberal or pathologically conservative. Finally, we apply the framework to a high-dimensional linguistic
dataset of Italian noun-noun compounds, proving its capacity to deliver robust, exact inference in environments where conventional analytical methods inherently fail.
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Statistical Methodology
Semiparametric Inference for Half-Trek Estimators in Linear Structural Equation Models
Leopold Mareis, Nils Sturma and Mathias Drton
Linear structural equation models on directed mixed graphs encode causal relationships among variables subject to latent confounding. The half-trek criterion (HTC) provides a graphical sufficient condition for the structural coefficients to be rationally identifiable from the observable covariance
matrix, and yields a corresponding closed-form rational
estimator. Despite this, the asymptotic distribution of the HTC
estimator, and hence valid standard errors and confidence regions, have not been derived. We derive the semiparametric influence function of this
estimator for all HTC-identified directed mixed graphs, including cyclic ones. The influence function combines the structural residual at the target node with the identification instruments, recursively corrected for uncertainty from earlier estimation stages. The HTC
estimator is asymptotically normal with variance computable in closed form, yielding confidence regions, marginal intervals, and Wald tests for individual structural coefficients. Applied to the Fulton Fish
Market dataset, our theory delivers a complete inferential summary for the causal effect of supply on demand.
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Machine Learning (Statistics) · Cross-listed from cs.LG
Asymptotically Optimal Learning for Parametric Prophet Inequalities
Jung-hun Kim, Anna Grebennikova and Vianney Perchet
We study learning in prophet inequalities with i.i.d. rewards drawn from an exponential-type parametric family with an unknown parameter $\theta$, a class that includes exponential, Pareto, and bounded-support power-family distributions. We first characterize the optimal full-information asymptotic competitive ratio for this family. In the unbounded-support case, the limit is $ {\left({\theta}/({\theta-c_+})\right)^{c_+/\theta}}/ {\Gamma(1-c_+/\theta)},$ while in the bounded-support case, the limit is $1$. We then propose a confidence-based dynamic-programming policy for online learning. By exploiting the explicit parametric structure, the policy achieves the same optimal asymptotic competitive ratio using only online observations, without external offline samples. We further derive distribution-specific convergence rates for canonical examples. Finally, numerical experiments on synthetic instances illustrate the performance of our
algorithm.
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Statistical Computation · Cross-listed from math.NA
Accelerated sampling using SamAdams variable timesteps and position-adaptive Langevin dynamics
Benedict Leimkuhler and Peter A. Whalley
We introduce an accelerated Langevin-based sampling method that is based on two complementary devices: SamAdams adaptive timestepping, which automatically shrinks the effective integration step in stiff regions of phase space using a relaxed stiffness monitor, and position-adaptive Langevin (PAL) dynamics, which concentrates friction along the local force direction while preserving the canonical distribution as the exact invariant measure. The resulting combined scheme (SA-PAL) is implemented in a palindromic integrator which requires only one force evaluation per iteration through suitable organisation of the integration steps and by exploiting the rank-one-plus-scalar structure of the PAL friction tensor. We test the method on various model problems: the Rosenbrock function, a thin entropic channel, the Mueller-Brown potential, and a
Bayesian parameterisation problem with a sparsity-inducing shrinkage prior. On the Rosenbrock and Mueller-Brown potentials mixing rates are improved by 1.5-3 times compared to fixed stepsize integration. Efficiency gains of more than an order of magnitude are documented in the other examples.
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Statistical Methodology
High-dimensional reliability-oriented Shapley effect estimation with Normalizing Flows
Lucas Monteiro, Jérôme Morio, Julien Demange-Chryst et al. (+1 more)
This article presents a new estimation scheme for the reliability-oriented Shapley effects when there is a large number of correlated input variables in the model, using a unique sample of failure points. To do so, we first propose a new writing of the reliability-oriented closed Sobol indices involving the marginal densities conditionally to the failure, which may be high-dimensional. Then, we propose to estimate these densities with the available failing samples using Normalizing Flows, powerful tools from generative modeling that enable the estimation of complex high-dimensional densities. In addition, we provide an error estimation procedure relying on the same sample of failing points, which constitutes a new contribution for the estimation of target Shapley effects. Finally, we illustrate our methodology on numerical use-cases, discuss insightful features of our approach and provide prospects for the future.
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All authors Lucas Monteiro, Jérôme Morio, Julien Demange-Chryst, François Bachoc
Statistical Methodology
Optimizing Experimental Design for Causal Effect Estimation with Partial Measurements
Leopold Mareis
Instrumental variable regression quantifies causal effects between a possibly confounded treatment variable $ X_2 $ and a response variable $ X_3 $ by leveraging an instrument $ X_1 $. Our work considers the setting where some prior information of the joint distribution of $ X_{123} $ is given, potentially through an initial
dataset. However, further samples must be gathered to improve the accuracy of the estimation. We show that under specific parameter configurations in a Gaussian graphical model, taking partial samples from, e.g., $ X_{12} $ can reduce the asymptotic variance of a consistent
estimator. This idea is developed by adding a budget constraint over the cost per (partial) sample. The optimization problem is analytically solvable over the real numbers and gives the optimal number of requested partial and complete samples. We provide significance level, power, and sample-size calculations for detecting a non-zero causal effect under optimal budget allocation. Our method can considerably reduce the necessary budget and the number of complete samples. Finally, we showcase the advantages and applicability of adaptive causal effect estimation for automotive analytics and pharmaceutical research.
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Machine Learning (Statistics) · Cross-listed from q-fin.PM
Data-Driven Duration Management – Term Structure Forecasting Using Machine Learning
Tobias Lausser, Joao Eduardo Vuolo and Rudi Zagst
This paper compares different methods for
forecasting the term structure of U.S. and European zero-coupon government bonds using both traditional econometric and Machine Learning (ML) approaches. We compare classical models (e.g., Dynamic Nelson-Siegel (DNS) and Principal Component Analysis (PCA)) with different Neural Network (NN) architectures, including those inspired by the classical models, on the U.S. Treasury
market and bonds issued by the European Central Bank (ECB). To enhance predictive performance, macroeconomic variables are incorporated. The findings for both
markets are separately analyzed and compared. To this end, we propose a robust model evaluation framework combining statistical accuracy metrics - such as RMSE, MAE, and directional accuracy - with the economic relevance of a quantitative bond trading strategy. Results show that NNs consistently outperform traditional models in both
forecasting accuracy and portfolio performance. For the U.S., the most effective approach is a direct-
forecasting NN that incorporates DNS factors to reduce the dimensionality of zero-rate data and an Autoencoder (AE) to extract macroeconomic features, while for Europe, the optimal model is a factor-based NN using PCA-derived zero-rate factors without the integration of macroeconomic variables. Overall, the paper demonstrates how combining traditional modeling approaches with modern ML techniques and evaluation can improve yield curve forecasts and support applications in fixed-income portfolio construction.
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Statistical Methodology
Structured Secant Methods to Select Smoothing Parameters for General Smooth Models
Joshua Krause, Jelmer P. Borst and Jacolien van Rij
General smooth models replace parameters of a regular likelihood with additive models. The models can include parametric terms, Gaussian random effects, and smooth functions of
covariates. The latter are parameterized via a reduced-rank spline basis and regularized via weighted quadratic penalties placed on the basis coefficients. Estimates for these weights (i.e., smoothing parameters) can be obtained by optimizing the Laplace-approximate
Bayesian marginal likelihood. Existing (second-order) methods require the Hessian of the log-likelihood to solve this optimization problem approximately - exact optimization requires up to fourth order derivatives - which can be difficult to derive and expensive to evaluate. To address these problems, we present a quasi-Newton variant of the second-order Extended Fellner-Schall (EFS) optimization method. Our qEFS method relies on structured limited-
memory secant approximations to the Hessian of the log-likelihood and is principally first-order. However, the approximation can also be accumulated for a sub-block of the Hessian, with the remaining columns being constrained to match those of the actual Hessian. The exact columns then provide additional structure for the sub-block approximation, which becomes more accurate as a result. We show that the qEFS method converges to the EFS method under certain conditions and continues to provide good estimates beyond these circumstances, which we illustrate in simulation studies. Secondary tasks involving the Hessian (confidence interval coverage & model selection) require partial approximations to achieve close to nominal performance. We provide Hidden Markov and Tweedie model examples, for which the qEFS method is substantially easier to implement than alternative methods.
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Statistical Methodology
Multiple testing
Jesse Hemerik
This text provides an introduction to multiple hypothesis testing. It covers various error criteria and testing procedures, and includes references to relevant R packages. An earlier version of this text served as the lecture notes for a PhD-level course on multiple testing.
Statistical Methodology
End-to-end probabilistic hierarchical forecasting of large hierarchies via probabilistic top-down
Lorenzo Zambon, Dario Azzimonti and Giorgio Corani
Retail and supply chain operations rely on demand forecasts to drive decisions, from replenishment at the product level to capacity planning at the store level. These forecasts should be probabilistic, to allow risk-aware decisions, and coherent across the aggregation hierarchy, so that decisions taken at different levels are not based on conflicting demand forecasts. Producing such forecasts is computationally demanding; at retail scale, with hierarchies of hundreds of thousands of time series, this cost becomes a primary concern. Existing two-step forecast-then-reconcile procedures and end-to-end neural models scale poorly, rely on restrictive assumptions, or require specialized hardware and engineering effort. We propose e2eTD, a scalable method for coherent probabilistic
forecasting of large hierarchical and grouped time series. e2eTD directly forecasts only a small subset of aggregate series (about 0.3% of the hierarchy in our experiments), which are smoother and thus more predictable than the intermittent bottom series. The resulting forecast samples are propagated to the bottom level through a novel probabilistic top-down sampling
algorithm, in which the historical disaggregation proportions are modeled as joint distributions, estimated in-sample. Since the bottom samples retain the cross-series dependence, summing them yields coherent forecasts for all aggregation levels. On the M5 and Favorita
datasets, e2eTD achieves the lowest weighted scaled pinball loss across aggregation levels among all competing methods; it would have ranked 11th of 892 teams in the M5 Uncertainty competition. On a standard laptop, e2eTD runs in about five minutes on M5 ($\sim$40K series) and twenty minutes on Favorita ($\sim$300K series).
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Machine Learning (Statistics) · Cross-listed from cs.LG
Escaping Iterative Parameter-Space Noise: Differentially Private Learning with a Hypernetwork
Naoki Nishikawa, Shokichi Takakura and Satoshi Hasegawa
Differentially private (DP) training of neural networks is often hindered by the large amount of noise required by gradient-based methods such as DP-SGD, which repeatedly inject high-dimensional noise in parameter space throughout training. In this paper, we propose a new framework for DP learning that avoids iterative optimization in parameter space. Instead of updating the target model using privatized gradients, we employ a hypernetwork trained on public
datasets to map a private
dataset to the parameters of the target model. Specifically, each example is embedded into a low-dimensional representation, the
embeddings are aggregated and perturbed to obtain a DP
dataset embedding, and the hypernetwork generates the target model parameters from this noisy
embedding. Because
privacy noise is injected only once into a low-dimensional
dataset representation, our approach can significantly reduce the adverse effect of noise. We theoretically show in a synthetic setting that, under a fixed
privacy budget, models produced by our approach achieve higher utility than those trained with DP-SGD. Moreover, we apply our approach to LoRA fine-tuning of
diffusion models and show that it achieves lower FID than LoRA models trained with DP-SGD and other public-data-guided methods.
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Statistics Theory
Scalable Operator Learning via Nyström Approximation With Denoising Applications
Naveen Gupta, Vaibhav Silmana and S. Sivananthan
In this paper, we study Nyström subsampling for vector-valued regression in vector-valued reproducing kernel
Hilbert spaces. Standard kernel methods often suffer from prohibitive computational costs due to the construction and inversion of large kernel
matrices, which limits their scalability to large
datasets. To overcome this bottleneck, we propose an efficient operator learning
algorithm based on Nyström subsampling that accommodates functional outputs. Under general source conditions characterized by index functions-extending beyond the classical Hölder-type and operator-monotone frameworks-we establish minimax-optimal convergence rates for the proposed
estimator. As an application of the proposed framework, we consider function denoising problems. Unlike classical denoising methods, which are typically tailored to specific signal representations or noise models, our approach formulates denoising within a general operator learning framework. Numerical experiments on signal denoising, real-time audio denoising, image denoising, inverse Radon transform reconstruction, and energy-efficiency prediction confirm that the proposed method achieves performance comparable to full kernel methods while substantially reducing computational cost.
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Statistical Methodology
Multivariable Mendelian randomization with weak instruments: a comparison of Bayesian and frequentist methods
Andrew J. Grant, Ashish Patel and Stephen Burgess
Weak instruments are a well known limitation for valid causal inference in Mendelian randomization studies. In the single exposure setting, weak instrument bias can be mitigated by selecting genetic instruments which are strongly associated with the exposure according to p-value and/or F-statistic thresholds. However, in the multi-exposure setting, genetic instruments may be strongly associated with an exposure but weakly associated with it conditional on all other exposures in the analysis. It is therefore more difficult to guarantee conditionally strong instruments in multivariable Mendelian randomization. Weak instrument bias can be mitigated using modelling approaches, however there are fewer methods for doing this in the multivariable case compared with the single exposure case. In this paper, we consider a method for mitigating weak instrument bias in multivariable Mendelian randomization using a
Bayesian framework: MVMR-Pony. We compare this method with existing frequentist methods. We show using simulation studies that the MVMR-Pony method outperforms the frequentist approaches with respect to bias, coverage, type I error rates, and power, across settings where weak instrument bias arises due to correlated genetic effects, measurement error, and mediation.
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Statistical Methodology
Doubly Robust Quadratic Inference Functions for Causal Inference in Cluster Randomized Trials
Hengshi Yu
Quadratic inference functions (QIF) provide a robust and efficient alternative to generalized estimating equations (GEE) for marginal regression with correlated data, particularly in cluster randomized trials (CRTs). However, existing QIF methodology does not account for confounding due to
covariate imbalance between treatment arms, a common concern in observational CRTs or CRTs with prognostic
covariate adjustment. We propose a doubly robust QIF (DR-QIF)
estimator that combines doubly robust pseudo-outcomes, constructed from propensity score and outcome regression models, with the QIF extended score equations. The DR-QIF
estimator is consistent for the average treatment effect when either the propensity score model or the outcome regression model is correctly specified, but not necessarily both. We show that DR-QIF is more efficient than doubly robust GEE (DR-GEE) when the working correlation structure is misspecified, and we characterize the asymptotic efficiency gain analytically. For cross-sectional CRTs the two
estimators are algebraically identical; efficiency gains emerge in longitudinal CRTs with strong temporal correlation, reaching 3.5% at N=120 and T=8 repeated measures. Finite-sample properties are evaluated via Monte Carlo simulation, and the method is illustrated using data from the WASH Benefits Kenya cluster randomized trial.
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Statistical Methodology
$\lambda$-PSD: Scalable Approximate SNR-Optimised Polynomial Stein Discrepancies
Minh-Long Nguyen, Thanh-Long Vu, Christopher Drovandi et al. (+2 more)
Polynomial Stein discrepancies (PSD) provide a scalable alternative to kernel Stein methods for measuring sample quality and goodness-of-fit testing, but their statistical properties remain poorly understood. We show that increasing
polynomial degree primarily amplifies signal without adequately controlling variance, rather than directly optimising the signal-to-noise ratio (SNR). Under suitable assumptions, this might lead to a failure mode in which the $\text{SNR}^2$ can provably decay exponentially with
polynomial degree. Motivated by this observation, we reformulate Stein discrepancy construction as an explicit $\text{SNR}^2$ maximisation problem, yielding a Rayleigh quotient over Stein features. This perspective motivates $\lambda$-PSD, an approximate scalable covariance-aware reweighting scheme defined in a low-dimensional subspace. Under Gaussian settings, we show that $\lambda$-PSD avoids the exponential $\text{SNR}^2$ collapse and achieves a stable $\text{SNR}^2$. Empirically, $\lambda$-PSD substantially improves test power while retaining linear-time complexity in the number of samples, highlighting the importance of SNR-aware design for scalable Stein discrepancies.
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All authors Minh-Long Nguyen, Thanh-Long Vu, Christopher Drovandi, Leah F. South, Trung-Tin Nguyen
Statistical Methodology
Fast Robust Regression via Orthogonal Block Updates
Anthony Christidis and Matias Salibian-Barrera
Robust regression methods, particularly MM-
estimators, are essential for analyzing
datasets where heavy-tailed noise or high-leverage outliers may be present.
Algorithms to compute these
estimators are iterative and rely on having a good initial point. A widely-used probabilistic approach to obtaining an initial regression
estimator that is not affected by outliers consists of fitting linear regression models to many random subsets of the training data. Unfortunately, the number of subsets that need to be considered in order to have a high probability of finding one that is clean of outliers grows exponentially with the number of predictors. This renders the approach unfeasible for models with a moderate to large numbers of variables. Alternative non-
stochastic strategies that have been proposed recently also fail to scale well when the number of parameters and observations are large. To overcome this problem, we propose a highly scalable
algorithm based on block-coordinate descent. Our Robust Orthogonal Block Updates (ROBU)
algorithm uses lower-dimensional blocks of explanatory variables, which require much fewer sub-samples to find a good initial point with high probability. Extensive simulations and a proteogenomics data application illustrate the robustness properties of the
estimators computed with ROBU and demonstrate that they compare favourably to those calculated with existing
algorithms.
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Statistical Methodology
A Unified Three-Stage Weighting Framework for Causal Inference and Mediation Analysis under Case-Control Sampling
Tarikul Islam and Mahbub A.H.M. Latif
Case-control studies are widely used in epidemiology and biomedical research because they provide substantial efficiency gains when outcomes are rare or prospective follow-up is impractical. However, retrospective outcome-dependent sampling distorts the population outcome distribution, creating fundamental challenges for causal inference. We propose a unified three-stage weighting (3S-weighting) framework for causal inference and causal mediation analysis from case–control studies. The proposed approach first estimates the unknown population outcome prevalence using density-ratio learning and label-shift correction combined with externally available
covariate information. Next, prevalence-based design weights are used to reconstruct the target population distribution from the retrospective sample. Finally, stabilized causal and mediation weights are applied within a marginal structural modeling framework to estimate total and pathway-specific causal effects, including the pure direct effect, pure indirect effect, and interaction effect. Simulation studies demonstrate that conventional analyses that ignore retrospective sampling can produce substantial bias in both total and mediation effect estimates, whereas the proposed approach consistently recovers the target population causal parameters across a range of sampling scenarios. An application of data from the National Health and Nutrition Examination Survey further illustrates the practical implementation and utility of the proposed framework.
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Machine Learning (Statistics) · Cross-listed from cs.LG
Learning Probabilistic Filters with Strictly Proper Scoring Rules
Eviatar Bach, Ricardo Baptista, Jochen Bröcker et al. (+2 more)
Bayesian filtering of partially and noisily observed dynamical systems seeks to infer the evolving conditional distribution of the state of a dynamical system given observations, in an online fashion. This
Bayesian filtering distribution is rarely available as a supervised learning target. However, one can often use the forecast model to generate synthetic trajectories, with corresponding synthetic observations. We introduce the proper scoring ensemble filter (PSEF), an ensemble data assimilation method trained using only synthetic trajectories. The analysis step is represented as a permutation-equivariant,
transformer-based map. Training is based on strictly proper scoring rules—with the energy score used in our implementation—so that probabilistic accuracy is rewarded over the whole probability distribution. Under a realizability assumption, the population mean-field objective is minimized by the true
Bayesian filtering distribution. Our methodology allows the same learned parameters to be shared between different ensemble sizes, subject to an ensemble-dependent fine-tuning. Numerical experiments show that the learned filter accurately approximates challenging filtering distributions, including highly non-Gaussian and multi-modal posteriors, and achieves stronger performance in data assimilation tasks than classical methods or learning-based methods with mean-squared-error objectives.
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All authors Eviatar Bach, Ricardo Baptista, Jochen Bröcker, Bohan Chen, Andrew Stuart
Statistical Methodology
Learning rate selection via weighted Fisher divergence
Takahiro Onizuka
The general
Bayesian approach provides a flexible framework by introducing a loss-based likelihood with a learning rate controlling the relative weight of the likelihood and prior. This flexibility creates an important calibration problem under model misspecification, where the conventional
Bayesian information identity fails and uncalibrated Gibbs posteriors may not provide reliable uncertainty quantification. We propose a method for selecting the learning rate by minimizing a weighted Fisher divergence between the asymptotic general posterior and a normal distribution with sandwich-type covariance, yielding a closed-form calibrated learning rate. The proposed framework includes Fisher information matching as a special case and, for an important choice of the weight
matrix, yields a learning rate no larger than the Fisher information matching rate. This leads to a more dispersed posterior and can reduce the risk of undercoverage. The framework also includes a learning rate based on Kullback–Leibler divergence as a special case. Numerical examples show that the proposed method tends to mitigate undercoverage under model misspecification, while real-data analyses illustrate its practical applicability.
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