Statistical Methodology
Estimating treatment duration effects via clone-censor-weight: a breast cancer case study
Charlotte Voinot, Noémie Simon-Tillaux, Emma Torrini et al. (+4 more)
In this work, we study the estimation of treatment duration effects in observational survival data, where treatment and
covariate histories evolve over time and longer observed durations are only attainable among individuals who remain event-free and under follow-up, leading to immortal time bias under naive analyses. The cloning-censoring-weighting (CCW) framework provides a practical approach to emulate target trials of treatment duration strategies, but several methodological aspects remain insufficiently understood. We focus on static treatment duration strategies under two settings of increasing complexity: baseline confounding only, and confounding with time-varying
covariates. We formalize the assumptions underlying CCW, with particular emphasis on treatment admissibility, relaxed intervention rules, and the distinction between artificial and natural censoring. We then compare several estimation approaches after cloning and censoring, including inverse probability of censoring weighting (IPCW), the G-formula, and doubly robust
estimators, through simulation studies assessing robustness, variability, and sensitivity to censoring model misspecification. Finally, we apply the framework to a Breast Cancer cohort to emulate a target trial comparing 2 versus 5 years of adjuvant tamoxifen in early stage breast cancer. Due to the small number of events and limited support for the 2-year strategy, estimates are associated with substantial uncertainty. These findings highlight both the practical relevance and the limitations of CCW, and underscore the importance of sensitivity analyses in complex longitudinal observational settings.
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All authors Charlotte Voinot, Noémie Simon-Tillaux, Emma Torrini, Stefan Michiels, Bernard Sebastien, Clément Berenfeld, Julie Josse
Statistics Theory
Error Bounds for Importance Sampling with Estimated Proposal Distributions
Cathrine Aeckerle-Willems, Ilja Klebanov and Simon Weissmann
Importance sampling with data-driven proposal distributions is widely used in practice. A common workflow first generates an auxiliary sample of size $N$ from an approximation of the target distribution, constructs a density estimate $\hat q$ such as a kernel density
estimator (KDE), and then draws $n$ importance samples from this learned proposal. Despite its practical relevance, the theoretical properties of this hierarchical procedure remain poorly understood, since classical importance sampling theory assumes a fixed proposal. We address this gap by deriving non-asymptotic error bounds for standard, defensive, and self-normalized importance sampling
estimators with random proposals. Our results separate the Monte Carlo error, scaling as $n^{-1/2}$, from the proposal approximation error measured through the mean integrated absolute and squared errors (MIAE and MISE) of $\hat q$. To obtain explicit convergence rates in $(N,n)$, we establish MIAE and MISE bounds for KDEs constructed from geometrically ergodic Markov chains in stationary and non-stationary regimes. Combining these results yields quantitative guarantees for importance sampling with KDE-based proposals. Our theory provides practical guidance for selecting defensive mixture weights in a nonparametric importance sampling framework.
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Statistical Methodology
Variance-Reduced Manifold Sampling via Polynomial-Maximization Density Estimation
Serhii Zabolotnii
Uniform sampling on implicitly defined
manifolds is a core primitive in motion planning, constrained simulation, and probabilistic machine learning. MASEM addresses this problem by
entropy-maximizing resampling, but its resampling weights depend on a local k-nearest-neighbour density estimate whose errors can be amplified by aggressive resampling temperatures. We ask whether a
polynomial-maximization moment
estimator can replace the plug-in density rule without changing the surrounding MASEM architecture. The proposed PMM-MASEM module computes shell spacings from nested k-nearest-neighbour radii, estimates their standardized cumulants, and uses a gated PMM2/PMM3
estimator only when the spacing distribution departs from the flat Exp(1) regime; otherwise it falls back to the plug-in/MLE rule. This fallback is essential: on a flat homogeneous
manifold the plug-in
estimator is already the MLE, so PMM should not outperform it. A local Known-DGP Monte Carlo experiment confirms this gate: the selector returns MLE on flat Exp(1) spacings and reduces density MSE by 22–36% on asymmetric gamma and boundary-spacing regimes. The evidence is not uniformly positive: PMM3 worsens a platykurtic uniform spacing law, and a lightweight resampling-proxy experiment improves seven-lobes coverage but degrades the sine and swiss-roll proxies. The current evidence therefore supports an applicability-boundary result rather than a general MASEM improvement claim.
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Statistics Theory
Uniform projection designs under the stratified $L_2$-discrepancy
Sixu Liu and Yaping Wang
This paper studies a uniform projection criterion for space-filling designs under the stratified $L_2$-discrepancy. The criterion, denoted by $\Phi_{SD}$, is the average squared stratified $L_2$-discrepancy over all two-dimensional projections. For U-type $(n,m,s^p)$ designs, we derive an explicit formula for $\Phi_{SD}$ in terms of row-pairwise weighted hierarchical distances, and we establish sharp lower and upper bounds with equality conditions. We further show that many known optimal constructions attain the lower bound of $\Phi_{SD}$, and that designs attaining the lower bound of the full stratified $L_2$-discrepancy also attain the lower bound of $\Phi_{SD}$. The criterion can be evaluated in $O(n^2m)$ time, with a modest reduction in arithmetic operations compared with direct projection-wise evaluation. Numerical studies illustrate the theoretical results and show that $\Phi_{SD}$ is effective for assessing low-dimensional projection uniformity.
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Statistics Theory · Cross-listed from math.PR
Sharp Spectral Thresholds for Multi-View Spiked Wigner Models
Xiaodong Yang, Subhabrata Sen and Yue M. Lu
Motivated by
multimodal estimation, we study a multi-view spiked Wigner model in which several noisy
matrix observations contain correlated latent spikes. We derive a spectral
estimator for the latent spikes by linearizing approximate message passing (AMP). Our main result is an explicit sharp transition formula for its spectrum: for $L \geq 2$ views, letting $\lambda$ be the $L$-dimensional vector of spike strengths and $B$ the $L\times L$ limiting Gram
matrix of the spikes, the critical parameter is $\mathsf{SNR}(\lambda,B)=\lambda_{\max}[\mathrm{Diag}(\sqrt{\lambda}) (B \odot B) \mathrm{Diag}(\sqrt{\lambda})]$. When $\mathsf{SNR}(\lambda,B)<1$, the linearized AMP
matrix has no outlier beyond the right edge of its bulk spectrum. When $\mathsf{SNR}(\lambda,B)>1$, an informative outlier is pinned at the distinguished point $1$, and the associated eigenvector has explicit, nontrivial overlaps with the latent signals. Thus $\mathsf{SNR}(\lambda,B)=1$ gives the exact spectral weak-recovery threshold for the linearized AMP method. To establish our results, we analyze the correlated Gaussian noise
matrix through a
matrix Dyson equation and combine this deterministic description with finite-rank perturbation arguments adapted to the multi-view spike structure. We also show that, for a broad class of spike priors, the spectral threshold $\mathsf{SNR}(\lambda,B)=1$ coincides with the information-theoretic threshold for weak recovery, ruling out a statistical-computational gap for this class of priors.
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Statistical Methodology
Sample Size Determination Under Selection Bias: Robust Tolerance Limits for Prevalent Cohort Data
James H. McVittie, Martin Lysy and Masoud Asgharian
Tolerance limits have received considerable
attention in the statistical literature, with applications reaching far beyond their initial role in quality control. The well-known formula of Scheffé and Tukey (1944) establishes a simple, distribution-free relation between sample size and population coverage by two given order statistics and a given confidence level. A key requirement in applying this formula is the availability of an unbiased, representative sample from the population of interest. However, as it often happens in biological and medical applications, various logistical constraints may preclude the possibility of obtaining an unbiased sample. We derive extensions of this formula which accommodate a large class of biased sampling schemes including weight bias and censoring. The modified formulae are validated through a simulation study and compared to its unmodified counterpart. We illustrate the use of the modified formulae using the partially observed failure times for individuals with dementia using data collected from the Canadian Study of Health and Aging.
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Statistical Methodology
Stationary subspace analysis for spatial data
Perttu Saarela, Klaus Nordhausen, Jaakko Pere et al. (+1 more)
Stationary subspace analysis (SSA) is a blind source separation framework that decomposes linearly mixed multivariate data into stationary and nonstationary components. We extend SSA to spatially indexed data by introducing spatial stationary subspace analysis (spSSA), which explicitly accounts for spatial dependence. We propose three estimation procedures for the unmixing
matrix based on first- and second-order spatial statistics. Each procedure targets a different type of nonstationarity and can be formulated as the solution to a generalized
eigenvalue problem. To address situations where multiple forms of nonstationarity are present simultaneously, we combine the three procedures using approximate joint diagonalization. Simulation studies demonstrate that this combined approach yields superior separation performance. When the dimension of the nonstationary subspace is known, the proposed methods reliably recover the latent stationary and nonstationary components. However, determining this dimension remains a fundamental challenge in SSA, for which no generally accepted solution currently exists. Building on our estimation procedures, we propose a novel data augmentation approach to estimate the dimension of the nonstationary subspace and demonstrate its effectiveness through simulation studies. The proposed methodology is easily transferable to time series settings, making it of broader methodological interest.
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All authors Perttu Saarela, Klaus Nordhausen, Jaakko Pere, Anne M. Ruiz
Statistics Theory · Cross-listed from cs.LG
Set-Valued Policy Learning
Laura Fuentes-Vicente, Mathieu Even, Gaëlle Dormion et al. (+3 more)
Conventional treatment policies map patient
covariates to a single recommended intervention in order to maximize expected clinical outcomes. However, when multiple treatments yield statistically indistinguishable outcomes or when treatment has no effect, recommending a single intervention may result in somewhat arbitrary interventions, undermining clinical adoption and trust. To address this, we propose a set-valued policy learning paradigm. By outputting sets of valuable treatments whose cardinality reflects the recommendation's ambiguity, our approach better supports clinical decision-making. Evaluating a set-valued policy proves subtle due to the range of possible downstream decisions. To do so, we define the set-policy value using a choice function to model clinical decision-making, and we develop doubly robust
estimators thereof. Despite its practical importance, set-valued policy learning for categorical treatments remains largely unexplored. In this context, we introduce two complementary approaches: the Greatest Lower Bound method, which extends the learning-to-defer framework to multiple treatments, and conformal set-valued policy learning, which bridges the gap between unobserved ground-truth optimal treatments and estimated optimal treatment rules. Through experiments on synthetic data and real-world applications to trauma care and in-vitro fertilization (IVF), we demonstrate that our methods produce robust and actionable policies that naturally incorporate clinical considerations while effectively balancing performance and reliability.
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All authors Laura Fuentes-Vicente, Mathieu Even, Gaëlle Dormion, Antoine Chambaz, Uri Shalit, Julie Josse
Machine Learning (Statistics) · Cross-listed from cs.LG
Smooth Piecewise Cutting for Neural Operator to Handle Discontinuities and Sharp Transitions
Ha Dang, Sebastian Schmidt and Juergen Hesser
Neural operators have achieved strong performance in learning solution operators of partial differential equations (PDEs), but their inherently continuous representations struggle to capture discontinuities and sharp transitions. Existing approaches typically approximate such features within continuous function spaces, often requiring increased model capacity and high-resolution data. In this work, we propose Cut-DeepONet, a two-stage training framework that explicitly models discontinuities while reducing learning complexity. Our approach reformulates the problem via a lifting strategy, partitioning the domain into smooth subregions while representing discontinuities as boundaries in a higher-dimensional space. This separation aligns the operator learning task with the inductive bias of neural networks and avoids directly approximating discontinuities. An additional network predicts input-dependent discontinuity locations for unseen inputs, which are then used to guide the neural operator in generating smooth components within each region. Experiments on
benchmark PDEs show that Cut-DeepONet outperforms state-of-the-art methods, even when trained on low-resolution
datasets. The method excels on problems with discontinuities and sharp transitions, while using fewer trainable parameters. Our results highlight the benefits of changing the representation of operator learning rather than increasing model complexity.
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Statistics Theory · Cross-listed from cs.LG
A Van Trees Lower Bound for Fully Interactive Differentially Private Federated Learning
T. Tony Cai and Yicheng Li
Federated differentially private protocols can communicate over many adaptive rounds and reuse each client's local samples. Existing lower bound arguments for
federated DP are often restricted to noninteractive protocols or fresh batch decompositions, so the fundamental information-theoretic limit of estimation under fully interactive protocols remains unknown. We establish a
federated van Trees inequality for parameter estimation under squared \ell_2 loss from any complete public transcript satisfying a clientwise zCDP constraint at the sample level. A scalar trace form covers homogeneous experiments, while a
matrix form preserves directional Fisher geometry in heterogeneous experiments where different clients are informative in different subspaces. Together with existing upper bounds for the corresponding problems, these results identify the minimax rates for various statistical problems including mean estimation, linear regression, nonparametric regression, and functional mean estimation over the full class of interactive public-transcript protocols. For these problems, arbitrary public interaction and repeated sample reuse do not improve the rate over simpler restricted protocols. The key technical ingredient in our paper is a contraction inequality for the Fisher information in the transcript: each client's contribution is bounded both by the Fisher information in its local experiment and by its total
privacy budget.
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Statistics Applications · Cross-listed from cs.LG
FLUXtrapolation: A benchmark on extrapolating ecosystem fluxes
Anya Fries, Jacob A Nelson, Martin Jung et al. (+2 more)
We introduce FLUXtrapolation, a
benchmark for extrapolating ecosystem fluxes under progressively harder distribution shifts. Ecosystem fluxes are central to understanding the carbon, water, and energy cycles, yet they can only be measured directly at sparsely located measurement towers. Producing global flux estimates therefore requires training models on observed sites using globally available
covariates and predicting in unobserved regions, that is, upscaling. Flux upscaling is a challenging domain generalization problem that is affected by a shift in
covariate distribution across climates, ecosystem types, and environmental conditions, as well as by conditional shift: important drivers remain unobserved at global scale. We provide a quantitative analysis of both these shifts in $P_X$ and $P_{Y\mid X}$. FLUXtrapolation is designed based on domain expertise on flux upscaling: it defines temporal, spatial, and temperature-based extrapolation scenarios and evaluates performance across held-out domains, temporal aggregations, and tail errors. In a pilot study, we find that baselines perform similarly under median hourly RMSE, but separate under the proposed tail-focused and multi-scale evaluation. FLUXtrapolation therefore poses a realistic and thus relevant challenge for machine learning methods under distribution shift; at the same time, progress on this
benchmark would directly support the scientific goal of improving flux upscaling.
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All authors Anya Fries, Jacob A Nelson, Martin Jung, Markus Reichstein, Jonas Peters
Statistical Methodology
Reliable model selection in the presence of parameter non-identifiability
Yong See Foo, Torkel E. Loman, Alexander P. Browning et al. (+3 more)
Mathematical models are invaluable for understanding and predicting how biological systems behave, although their construction requires specifying mechanisms and relationships that are often not perfectly known. In the presence of multiple competing models, model uncertainty should be accounted for when performing inference based on available data.
Bayesian model selection is a framework for testing mechanistic hypotheses and generating predictions under model uncertainty, which generally requires computation of the model evidence. In this work, we investigate the reliability of evidence computation methods when parameter non-identifiability – the inability to distinguish between parameter values given available data – is present, and find that deterministic evidence approximations can produce misleading model selection results because their underlying assumptions are violated. We propose a novel implementation of adaptive multiple importance sampling for evidence estimation, and demonstrate its robustness against non-identifiability. We use ecological case studies to demonstrate how simple model selection methods fail to produce accurate results, whereas our method yields model selection results that are comparable to those obtained by Markov chain Monte Carlo methods at substantially lower computational cost. Given the pervasiveness of parameter non-identifiability in mathematical biology, this work provides a practical approach to reliable model selection in the presence of poorly identified parameters.
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All authors Yong See Foo, Torkel E. Loman, Alexander P. Browning, Ivo Siekmann, Ruth E. Baker, Jennifer A. Flegg
Machine Learning (Statistics) · Cross-listed from cs.LG
Latent Laplace Diffusion for Irregular Multivariate Time Series
Zinuo You, Jin Zheng and John Cartlidge
Irregular multivariate time series impose a trade-off for long-horizon
forecasting: discrete methods can distort temporal structure via re-gridding, while continuous-time models often require sequential solvers prone to drift. To bridge this gap, we present Latent Laplace
Diffusion (LLapDiff), a generative framework that models the target as a low-dimensional latent trajectory, enabling horizon-wide generation without step-by-step integration over physical time. We guide the reverse process utilizing a stable modal parameterization motivated by
stochastic port-
Hamiltonian dynamics, and parameterize its mean
evolution in the Laplace domain via learnable complex-conjugate poles, enabling direct evaluation over irregular timestamps. We also link continuous dynamics to irregular observations through renewal-averaging analysis, which maps sampling gaps to effective event-domain poles and motivates a gap-aware history summarizer. Extensive experiments show that LLapDiff improves over baselines in long-horizon
forecasting, and its continuous-time generative nature supports missing-value imputation by querying the same model at historical timestamps. Code is available at https://github.com/pixelhero98/LLapDiffusion.
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Statistics Theory · Cross-listed from math.OC
Fast Spawn&Prune (FS&P): Global convergence of stochastic conic particle gradient descent via birth/death process
Yohann De Castro, Sébastien Gadat and Clément Marteau
We investigate the global optimization of the objective function arising in continuous sparse regression, specifically the Beurling LASSO (BLASSO), over the space of measures. While Conic Particle Gradient Descent (CPGD) methods are computationally efficient, they may become trapped in local minima due to the non-convexity of the parameterization. To overcome this limitation, we introduce Fast Spawn&Prune (FS&P), a
stochastic algorithm that extends FastPart introduced in De Castro et al. (2025) and combines CPGD with a birth-death process. The birth mechanism ensures asymptotic global exploration by introducing particles in regions where first-order optimality conditions are violated, while the death process preserves computational efficiency by
pruning non-informative particles. We provide the first theoretical guarantee of global convergence for this class of discrete-time
stochastic algorithms, without requiring exponentially large initializations. Furthermore, we derive explicit convergence rates for the excess risk, which scale as $\mathcal{O}\big(\left(\log K / K\right)^{\frac{1}{2(2+d)}}\big)$, where $K$ denotes the number of iterations and d the dimension of the domain, thereby quantifying the trade-off between global exploration and local refinement. Moreover, the sample complexity is $\mathcal{O}\big(N^{-\frac{1}{4(2+d)}}\big)$ (up to logarithmic factors). We also propose a horizon-free variant that does not require prior knowledge of the iteration budget.
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Statistical Methodology
Assessing covariate-adjusted risk differences in small-sample clinical trials
Martin Schnuerch, Alex Ocampo, Klaus Kähler Holst et al. (+1 more)
Binary endpoints are common in clinical trials and conditional odds ratios have traditionally been used to assess treatment effects. However, the interpretation of odds ratios is difficult, they are non-collapsible, and conditional odds-ratios obtained from regression models additionally rely on modeling assumptions in order to be a relevant overall summary measure for the trial. As an alternative, risk differences have gained increasing prominence as a more interpretable, clinically meaningful and assumption-lean measure of treatment effects. This shift has also been motivated by new regulatory guidance, which emphasizes the relevance of marginal estimands and encourages
covariate adjustment. Yet,
covariate-adjusted inference for risk differences, particularly in smaller samples, has methodological subtleties and lacks well-established best practices. We conduct a simulation study comparing methods for estimating and testing risk differences in small-sample (N$\,\leq\,$150) randomized clinical trials with prognostic categorical baseline
covariates, focusing on exact unconditional tests, Mantel-Haenszel methods, and $g$-computation (standardization) approaches. We find that several $g$-computation approaches exhibit inflated Type I error in very small samples when standard Wald-type inference is applied, whereas robust or penalized variants improve error control at the expense of power. Classical methods such as the Mantel-Haenszel and Suissa-Shuster tests remain robust but may forgo efficiency gains from
covariate adjustment. Overall, our results suggest that misalignment between estimand and variance estimation may contribute to the Type I error inflation, beyond the impact of small sample size alone. Based on these results, we provide practical recommendations to guide method selection that align the estimand, variance estimation, and inferential target.
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All authors Martin Schnuerch, Alex Ocampo, Klaus Kähler Holst, Christian Stock
Statistics Theory · Cross-listed from cs.AI
Minimax Optimal Variance-Aware Regret Bounds for Multinomial Logistic MDPs
Pierre Boudart, Pierre Gaillard and Alessandro Rudi
We study reinforcement learning for episodic Markov Decision Processes (MDPs) whose transitions are modelled by a multinomial logistic (MNL) model. Existing
algorithms for MNL mixture MDPs yield a regret of $\smash{\tilde{O}(dH^2\sqrt{T})}$ (Li et al., 2024), where $d$ is the feature dimension, $H$ the episode length, and $T$ the number of episodes. Inspired by the logistic bandit literature (Abeille et al., 2021; Faury et al., 2022; Boudart et al., 2026), we introduce a problem-dependent constant $\bar\sigma\_T \leq 1/2$, measuring the normalised average variance of the optimal downstream value function along the learner's trajectory. We propose an
algorithm achieving a regret of $\smash{\tilde{O}(dH^2\bar\sigma\_T\sqrt{T})}$, which recovers the existing bound in the worst case and improves upon it for structured MDPs. For instance, for KL-constrained robust MDPs, $\bar\sigma\_T = O(H^{-1})$, reducing the horizon dependence by a factor $H$. We further establish a matching $\smash{\Omega(dH^2\bar\sigma\_T\sqrt{T})}$ lower bound, proving minimax optimality (up to logarithmic factors) and fully characterising the regret complexity of MNL mixture MDPs for the first time.
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Machine Learning (Statistics) · Cross-listed from cs.AI
CogScale: Scalable Benchmark for Sequence Processing
Yannis Bendi-Ouis, Romain de Coudenhove and Xavier Hinaut
The ability to maintain and manipulate information over time is a fundamental aspect of living beings and Artificial Intelligence. While modern models have achieved remarkable success in tasks like natural
language processing, evaluating the capacity of novel architectures to process sequential information remains computationally expensive and time-consuming. Testing a new architecture often requires scaling up to massive
datasets and models, leading to vast computational costs and slow iteration cycles. In this paper, we propose CogScale, a
benchmark of 14 scalable synthetic tasks designed to isolate and evaluate specific cognitive and
memory abilities at different parametrizable scales. By providing a standardized, lightweight framework, CogScale allows researchers to rapidly validate architectural innovations before committing to large-scale training. To establish a solid baseline, we evaluate seven distinct architectures: Gated Recurrent Unit (GRU), Long Short-Term
Memory (LSTM), xLSTM, Echo State Network (ESN), Mamba,
Transformer Decoder, and
Transformer Encoder-Decoder. These evaluations are conducted under strict parameter budgets (1k, 10k, and 100k) and across different difficulty levels and scales. Our results show that while classical RNNs and Echo State Networks excel at basic retention within strict parameter budgets, only
attention mechanisms and modern state-space models consistently maintain high performance as
reasoning complexity and task difficulty scale.
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Other Statistics
Making Uncertainty Visible: Multiverse Analysis for Robust Computational Social Science
Maximilian Linde, Jun Sun, Paul Balluff et al. (+2 more)
Through case studies, we demonstrate how multiverse analysis can strengthen the robustness and transparency of computational social science findings against alternative methodological decisions. We conduct multiverse analyses of three published social science studies that use the following computational methods:
Bayesian analysis, network generative modeling, and machine learning with or without large
language models. These methods are applied frequently in computational social science studies, yet entail a greater degree of arbitrariness in terms of methodological choices, or "researcher degrees of freedom." Our multiverse analyses reveal how the empirical findings in these studies vary as a function of various plausible decision combinations. Our three case studies also expose an often-ignored motivation for conducting multiverse analysis: Showing which methodological combinations lead to computational failure. These failed cases are usually not communicated in the published reports, even though these sophisticated computational methods have a much higher likelihood of failure. We end our paper with suggestions on how to find defensible decision combinations for multiverse analysis of computational social science studies and how to communicate multiverse analysis findings fairly.
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All authors Maximilian Linde, Jun Sun, Paul Balluff, Danica Radovanović, Chung-hong Chan
Statistical Methodology
Causal treatment effect decompositions with time-to-event outcomes under competing events
Mikko Valtanen, Tommi Härkänen, Jenni Lehtisalo et al. (+3 more)
Inference about treatment effects for time-to-event outcomes is often obscured by the presence of competing events. A particularly complex situation arises when the treatment influences the occurrence of the competing event. A comprehensive assessment should then account for different mechanisms by which the treatment and the competing event together produce the apparent treatment effect. Here, we propose a decomposition of the treatment's effect on the event of interest (target), characterising how it arises due to four distinct mechanisms involving both the target and competing events. Based on a causal model, the decomposition relies on cross-world estimands reflecting counterfactual scenarios in which the treatment affects the two events as if set to conflicting levels. We specify exchangeability and consistency assumptions under which the decomposition can be estimated from observed data. We discuss how the new decomposition reveals the role of the competing event and serves as a basis for defining causally interpretable estimands in the presence of competing events. Finally, we demonstrate the use of the four-way decomposition with
datasets from two randomised trials.
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All authors Mikko Valtanen, Tommi Härkänen, Jenni Lehtisalo, Tiia Ngandu, Miia Kivipelto, Kari Auranen
Machine Learning (Statistics)
Probabilistic Multivariate Time Series Forecasting with Diffusion Copulas
David Huk, Dongshan Wang and Miha Bresar
Accurately assessing financial risk requires capturing both individual asset
volatility and the complex, asymmetric dependence structures that emerge during extreme
market events. While modern
diffusion-based models have advanced multivariate
forecasting, they often suffer from a "normality bias" when trained end-to-end, sacrificing marginal calibration for joint coherence and consistently underestimating tail risk. To address this, we propose a
Diffusion-Copula framework that explicitly decouples the learning of marginal distributions from their dependence structure. We employ deep Mixture Density Networks to capture heavy-tailed asset dynamics, followed by a Classification-
Diffusion Copula to model the joint dependence. Applied to cryptocurrency
markets, our approach demonstrates superior performance over state-of-the-art baselines in
forecasting systemic extremes of both marginal and joint events. Crucially, we demonstrate that while baseline models classify simultaneous
market crashes as statistically impossible "Black Swans" (high surprise), our framework identifies them as "Expected Crashes" (low surprise), successfully preserving the correlation structure necessary for robust risk management during contagion events.
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Statistics Theory
Influence as soft sparsity: Estimation of monotone functions on $\{0,1\}^d$
Gérard Biau
We study the problem of estimating a monotone function $f:\{0,1\}^d\to[0,1]$ from noisy observations at uniformly random vertices of the Boolean hypercube. As a measure of complexity for the target~$f$, we use the total $L^1$-influence $I(f)=\sum\_{i=1}^d(\E[f(X)\mid X\_i=1]-\E[f(X)\mid X\_i=0])$, a classical quantity in Boolean analysis that is nonnegative for monotone functions and controls the effective dimensionality of the estimation problem: through a spectral concentration result in the spirit of Friedgut's junta
theorem, the
Fourier spectrum of any $f$ with $I(f)\leqslant K$ concentrates on low-degree subsets of the influential coordinates. We establish minimax bounds over the class $\cF\_K=\{f:\{0,1\}^d\to[0,1],\;f\text{ monotone},\; I(f)\leqslant K\}$: \[ c\,\frac{K^2}{(\log n)^{3/2}} \;\leqslant\; \inf\_{\hat f}\;\sup\_{f\in\cF\_K}\; \E\bigl[\|\hat f - f\|\_2^2\bigr] \;\leqslant\; C\,\frac{K}{\sqrt{\log n}}, \] where $n$ is the sample size. The upper bound holds for all $K\geqslant 1$ and is uniform in the ambient dimension~$d$ (under the mild condition $\log d\leqslant n^{1-\varepsilon}$). It is achieved by a
Fourier thresholding
estimator that adapts to the unknown~$K$. The lower bound relies on a Varshamov–Gilbert packing on the middle layer of the hypercube combined with Fano's inequality.
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Machine Learning (Statistics)
Increasing Missingness to Reduce Bias: Richardson-SGD with Missing Data
Ferdinand Genans and Erwan Scornet
Stochastic gradient methods are central to modern large-scale learning, but their use with incomplete
covariates remains delicate since imputation schemes generally introduce systematic gradient biases, as shown for linear models. In this work, we prove that all parametric models exhibit similar gradient bias for various imputation procedures and characterize exactly the dependence on the missingness ratio vector $p$, with $O(\|p\|)$ as the leading term. We exploit this analysis to propose a simple debiasing procedure for
stochastic gradient descent (SGD) with missing values based on Richardson extrapolation, which leverages the exact expression of the gradient bias. The key idea is to deliberately add missingness: from an already incomplete observation, we generate a further-thinned version at a higher, controlled missingness level, and combine the two resulting
stochastic gradients to cancel the leading bias term. We prove that one Richardson step reduces the gradient bias from $O(\|p\|)$ to $O(\|p\|^2)$ under several missingness scenarios. Our proposed method is computationally efficient, model-agnostic and applies to any parametric loss whose
stochastic gradient can be computed after imputation. Furthermore, when missing indicators are independent, the population gradient bias is a multilinear
polynomial in $p$ and depends only on population gradient errors induced by declaring a single coordinate missing. In this case, our method generalizes to a multi-step Richardson procedure which recursively cancels higher-order terms. Empirically, Richardson debiasing improves optimization and estimation across several generalized linear models and combines positively with widely used imputation procedures such as MICE. These results suggest that, somewhat counter-intuitively, adding controlled missingness on top of existing missing data can make
stochastic learning from incomplete data more accurate.
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Machine Learning (Statistics)
Gaussian Approximation and Multiplier Bootstrap for Federated Linear Stochastic Approximation
Ilya Levin, Maksim Shuklin, Eric Moulines et al. (+2 more)
In this paper, we establish Berry-Esseen-type bounds for
federated linear
stochastic approximation (LSA). Our results provide the first
federated Gaussian approximations for LSA that explicitly capture communication-computation trade-offs and heterogeneity-aware error terms, quantifying the effects of local step size, number of local updates, and heterogeneity on convergence rates. We present results for both (i) constant step size regime and (ii) decreasing step size with an increasing number of local iterations, recovering the recent rates of Bonnerjee et al. [2025] as a special case. As a primary application of our results, we develop an online multiplier bootstrap procedure for inference on the last iterate, which avoids explicit estimation of the asymptotic covariance
matrix, and obtain non-asymptotic validity guarantees for this procedure.
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All authors Ilya Levin, Maksim Shuklin, Eric Moulines, Paul Mangold, Sergey Samsonov
Machine Learning (Statistics) · Cross-listed from cs.LG
MiMuon: Mixed Muon Optimizer with Improved Generalization for Large Models
Feihu Huang, Yuning Luo and Songcan Chen
Matrix-structured parameters frequently appear in many artificial intelligence models such as large
language models. More recently, an efficient
Muon optimizer is designed for
matrix parameters of large-scale models, and shows markedly faster convergence than the vector-wise
algorithms. Although some works have begun to study convergence properties (i.e., optimization error) of the
Muon optimizer, its generalization properties (i.e., generalization error) is still not established. Thus, in this paper, we study generalization error of the
Muon optimizer based on algorithmic stability and mathematical induction, and prove that the
Muon has a generalization error of $O\big(\frac{1}{N\kappa^{T}}\big)$, where $N$ is training sample size, and $T$ denotes iteration number, and $\kappa>0$ denotes minimum difference between singular values of gradient estimate. To enhance generalization of the
Muon, we propose an effective mixed
Muon (MiMuon) optimizer by cautiously using orthogonalization of gradient, which is a hybrid of
Muon and momentum-based SGD optimizers. Then we prove that our MiMuon optimizer has a lower generalization error of $O\big(\frac{1}{N}\big)$ than $O\big(\frac{1}{N\kappa^{T}}\big)$ of
Muon optimizer, since $\kappa$ generally is very small. Meanwhile, we also studied the convergence properties of our MiMuon
algorithm, and prove that our MiMuon
algorithm has the same convergence rate of $O(\frac{1}{T^{1/4}})$ as the
Muon algorithm. Some numerical experimental results on training large models including Qwen3-0.6B and YOLO26m demonstrate efficiency of the MiMuon optimizer.
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Statistical Methodology · Cross-listed from cs.LG
A Family of Divergence Measures for Evaluating the Reconstruction Quality of Explainable Ensemble Trees
Massimo Aria, Agostino Gnasso and Carmela Iorio
Validating interpretable surrogate models for ensemble learners requires measuring agreement between the ensemble's internal representation and its surrogate approximation, rather than mere association. Correlation-based approaches are scale-invariant and fail to detect systematic discrepancies in co-occurrence structure. We propose a statistical framework grounded in the agreement-association distinction, centered on the normalized Loss of Interpretability (nLoI). Rooted in the Cressie-Read power divergence family with lambda equal to 2, the nLoI admits a closed-form decomposition into within-node and between-node components, providing a unique diagnostic capability to identify precisely where and why reconstruction fails. The framework incorporates four complementary measures capturing distinct structural facets of approximation quality. A unified permutation testing procedure delivers valid inference for all measures within a single resampling pass. Theoretical properties, including boundedness and
symmetry, are established for each metric. Monte Carlo simulations and empirical evaluations confirm exact Type I error control and demonstrate that these measures detect reconstruction fidelity gradients invisible to correlation-based alternatives. The framework is developed and illustrated in the context of Explainable Ensemble Trees (E2Tree), and empirical evaluation on three
benchmark datasets illustrates the practical utility of the framework.
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Machine Learning (Statistics)
Posterior Contraction of Lévy Adaptive B-spline Regression in Besov Spaces
Jeunghun Oh, Sewon Park and Jaeyong Lee
We investigate the asymptotic properties of the Lévy Adaptive B-spline (LABS) regression model, a
Bayesian nonparametric method that incorporates B-spline kernels into the Lévy Adaptive Regression Kernel (LARK) model. LABS applies splines of varying degrees with independently defined
knots, yielding a flexible model class capable of adapting to irregular and locally structured features of the true function. Within the nonparametric regression framework with univariate random design and Gaussian errors, we establish that the LABS posterior contracts around the true function in Besov classes at nearly minimax-optimal rates, up to a logarithmic factor, while adapting automatically to unknown smoothness. This study contributes to filling a gap in the literature, where theoretical results on posterior contraction of the LARK model in Besov spaces remain scarce. Simulation experiments on standard test functions in Besov spaces, including Blocks, Bumps, HeaviSine, and Doppler, complement the theoretical results and demonstrate the practical utility of LABS.
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Statistical Methodology
Uncertainty-Aware Ideal Point Estimation via Variational EM with Pólya-Gamma identity
Kwangok Seo, Youngjo Lee, Jong Hee Park et al. (+2 more)
Roll-call data analysis aims to estimate legislators' ideal points and quantify the associated uncertainty. Existing approaches either rely on
Bayesian methods implemented via Markov chain Monte Carlo sampling or focus primarily on point estimation, with uncertainty typically assessed through resampling procedures such as the bootstrap. Consequently, the computational burden of these approaches can become substantial when applied to large roll-call
datasets. To address this challenge, we propose a computationally efficient likelihood method for estimating ideal points and their standard errors. Leveraging the Pólya-Gamma identity, we develop a variational expectation–maximization
algorithm for estimating ideal points and introduce a variational Louis' method to approximate the observed Fisher information for standard error estimation. Numerical studies and applications to U.S. congressional roll-call data demonstrate that the proposed method produces accurate ideal point estimates and reliable standard errors while being substantially more computationally efficient than existing approaches.
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All authors Kwangok Seo, Youngjo Lee, Jong Hee Park, Xinlei Wang, Johan Lim
Machine Learning (Statistics) · Cross-listed from cs.LG
Online Market Making and the Value of Observing the Order Book
Davide Maran and Marcello Restelli
We study an online
market-making problem in which a learner sequentially posts bid and ask prices for a single asset while interacting with traders holding private valuations. Unlike existing online learning formulations that assume fully censored feedback, we introduce an action-dependent feedback model inspired by real limit order books: when a trade occurs, the trader's valuation remains hidden, whereas when no trade occurs, informative feedback about supply and demand is revealed. We show that this additional information fundamentally changes the learnability of the problem. In the
stochastic setting with i.i.d.
market prices, we propose an elimination-based
algorithm that achieves $O(\sqrt T)$ regret with high probability, without requiring any smoothness assumptions on the distribution of trader valuations. We then extend this result to a broad class of mean-reverting price processes by considering both local, autoregressive dynamics and a weaker global drift condition based on cumulative deviations from the mean. Under either assumption, we establish high-probability $O(\sqrt T)$ regret bounds, relying on a new concentration inequality of independent interest. Finally, in the
adversarial setting with oblivious prices, we design an explore-then-perturb
algorithm that guarantees $O(T^{2/3})$ regret in expectation. Our results quantify the value of observing the order book in online
market making and demonstrate that even limited, action-dependent feedback can substantially improve regret guarantees compared to standard bandit feedback models.
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Machine Learning (Statistics)
Density-Ratio Losses for Post-Hoc Learning to Defer
Alexander Soen, Ragnar Thobaben, Joakim Jaldén et al. (+1 more)
We study post-hoc Learning to Defer (L2D) through the lens of ideal distributions: divergence-regularized reweightings of the data distribution under which a model attains low loss. We define deferral via the density-ratio between a model's and an expert's ideals. Using the reduction from density-ratio estimation to class-probability estimation, we derive the DR CPE losses for post-hoc L2D scorers. Deferral decisions are then made by thresholding the scorer, allowing deferral rates to be adjusted without retraining. For KL-based ideal distributions, our deferral rules recovers Chow's rule under the original distribution and a connection to an expert-tilted Bayes posterior – which incorporates the expert's performance – depending on if the ideal distributions are joint or marginal distributions. Experimentally, our approach is competitive compared to common baselines and more robust across
dataset settings. More broadly, our results cast post-hoc L2D as density-ratio learning between ideal distributions, bridging Chow-style rules, expert comparison, and elucidating connections to related learning settings including anomaly detection.
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All authors Alexander Soen, Ragnar Thobaben, Joakim Jaldén, Richard Nock
Statistical Methodology
Inference for Fréchet Regression
Wookyeong Song, Paromita Dubey, Hans-Georg Müller et al. (+1 more)
Linear regression is widely used to model relationships between responses and predictors. In modern applications, one encounters data where the responses are non-Euclidean random objects situated in a metric space, paired with Euclidean predictors. Global Fréchet regression generalizes linear regression to such general settings, however statistical inference has remained largely unexplored. We develop a significance test for the null hypothesis that the Fréchet regression function does not depend on the predictors, addressing the challenge of an absence of linear operations in metric spaces. We also develop a test for the partial effect of a subset of the predictors in analogy to, but quite different from, the partial F-tests commonly used in classical linear regression under Gaussian assumptions. Key ideas are to employ random multipliers to obtain non-degenerate null distributions for the proposed test statistics and the Cauchy combination method. We obtain consistency and convergence results under the null hypothesis and contiguous alternatives and demonstrate the finite sample performance of the proposed tests through simulations on network data represented by graph
Laplacians and spherical data with geodesic distances. We further illustrate our method using transport networks arising from New York City taxi trip data and U.S. energy source compositional data.
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All authors Wookyeong Song, Paromita Dubey, Hans-Georg Müller, Alexander Petersen