Statistical Methodology
Assessing the Impact of Model Assumptions in Network Meta-Regression: A Simulation Study
Nana-adjoa Kwarteng, Guido Schwarzer, Adriani Nikolakopoulou et al. (+1 more)
Network meta-regression (NMR) extends network meta-analysis (NMA) by synthesizing evidence on multiple treatments while adjusting for potential effect modifiers. By accounting for effect modification, NMR can reduce between-study heterogeneity and improve the validity of relative treatment effects, providing insight regarding characteristics impacting treatment performance. However, choosing between available NMR models is complex, as each model addresses a similar, but unique research question, and the performance of available NMR models under varying network structures, between-study heterogeneity, and interaction assumptions remains unclear. We evaluated the consequences of model misspecification in a simulation study of 120 evidence-network scenarios designed to reflect potential complications in evidence networks introduced by trial design, heterogeneity levels, and interaction assumptions. We compared the standard interaction-free NMA model with four NMR parameterizations differing in across-comparison interaction assumptions (common vs. independent interactions) and interaction consistency assumptions (with or without consistency). Standard NMA models generally overestimated treatment effects when effect modification was present. NMR models with independent across-comparison interactions maintained appropriate confidence interval coverage in dense networks generated with their corresponding consistency assumptions. However, their coverage deteriorated in sparse networks with between-study heterogeneity. Models assuming consistent interactions are advantageous in networks with multi-arm studies. Ignoring effect modification in NMA can lead to biased treatment effect estimates. When effect modification is anticipated, thoughtful
alignment between network structure and NMR assumptions can reduce bias and misleading precision, supporting more reliable medical decision making.
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All authors Nana-adjoa Kwarteng, Guido Schwarzer, Adriani Nikolakopoulou, Theodoros Evrenoglou
Statistical Computation · Cross-listed from math.NA
Pathwise skew-symmetric discretisation for SDEs with superlinear drift
Yuga Iguchi, Samuel Livingstone, Giorgos Vasdekis et al. (+1 more)
The skew-symmetric discretisation has recently been proposed as a new robust simulation method for weakly approximating
stochastic differential equations (SDEs) with non-globally Lipschitz drift. This work develops a pathwise version of the scheme by representing the noise increment as a skew-normal distribution and coupling it with the driving Brownian increments, thereby enabling its use in the multilevel Monte Carlo (MLMC) framework. Under suitable conditions, we establish strong convergence of order 1/2 in $L^2$. Subsequently, the associated MLMC
estimator is shown to have computational complexity ${O} \bigl(\varepsilon^{-2} (\log (1/\varepsilon))^2 \bigr)$ to achieve a mean-squared error $\varepsilon^2$. We then analytically compare the proposed scheme with the tamed Euler scheme, another
benchmark for robust discretisation. Under a strong inward-drift regime with the current state being far from the stable region, we show that the probability of moving in the wrong direction tends to vanish in the skew-symmetric scheme, whereas the tamed Euler scheme makes such moves with a non-trivial probability. Furthermore, in the MLMC setting, employing a one-dimensional
stochastic Ginzburg-Landau model, we specify the range of step sizes for which the asymptotic variance of the coupled level difference obtained via the pathwise skew-symmetric scheme is lower than that obtained via the tamed Euler scheme. Numerical experiments on several model examples support the theoretical rate of strong convergence and demonstrate the stability and effectiveness of the resulting MLMC in the superlinear drift setting.
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All authors Yuga Iguchi, Samuel Livingstone, Giorgos Vasdekis, Rui-Yang Zhang
Statistics Theory
Decision-Centric Large Deviations for Data-Driven Capital Buffers in Ruin Models
Yf Henkes, Bart P.G. van Parys and Bert Zwart
We consider an insurance risk model with a random walk structure in which the underlying probability law is unknown. A decision maker observes a statistic $Q_n$ computed from $n$ historical observations and then needs to choose a capital buffer of the form $C_n=n f(c,Q_n)$, where $c=\log(1/\delta)/n$ balances the amount of data and the tolerated ruin probability $\delta$. The classical safe capital buffer is inversely proportional to the adjustment coefficient $\gamma$, the exponential rate at which the ruin probability decays; when the law is unknown, this coefficient must be inferred from the data. The profile $f$ couples the statistical cost of observing an atypical historical statistic with the future ruin exponent induced by the resulting decision. We study the joint ex ante probability (over both the historical sample and an independent future risk process) that the future maximum exceeds the data-dependent buffer. We show that the naive plug-in rule fails to achieve the prescribed logarithmic decay exponent $c$, illustrating the adverse impact of model uncertainty when making decisions under rare-event constraints. We then identify a profile $f^*=f^*(c,Q_n)$ with the following appealing properties: its lower semicontinuous majorants are safe, while regular continuous rules that fall strictly below $f^*$ are, under mild conditions, unsafe. We illustrate the potential applicability of our framework by developing three parametric examples. In nonparametric settings, we show that a single exponential envelope leads to degenerate capital buffers, whereas a two-level exponential envelope yields a nondegenerate capital buffer which we prove to be safe.
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Statistics Theory
A Functional Central Limit Theorem for Localized Partial Sums of Non-Stationary Time Series
Florian Heinrichs
A localized functional central limit
theorem is established for kernel-weighted partial sum processes of piecewise locally stationary time series under
geometric decay of the physical dependence measure. The localized process is shown to converge weakly to a centered Gaussian random distribution in $D'(0,1)$, and the limit extends naturally to an isonormal Gaussian process on $L^2([0,1])$. Weak convergence is further derived for processes indexed by totally bounded subsets of $L^2([0,1])$. As an application, the localized limit theory is used to construct tests for constant mean functions against linear,
polynomial, and general alternatives in non-parametric regression with locally stationary errors. Simulation results and data examples illustrate the finite sample performance and practical applicability of the proposed methodology.
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Machine Learning (Statistics)
An Adjoint-Sensitivity Framework for Lost-in-the-Middle Phenomena in Causal Residual Transformers
Cheng Huan and Hongwei Yuan
We develop an adjoint-sensitivity framework for positional influence in causal residual
Transformers and separate unconditional analytic results from conditional boundary-shape conclusions. The principal unconditional
theorem is the residual-to-depth-flow estimate for layer controls converging in $L^1$, complemented by a finite-
token-to-Volterra
attention estimate that explicitly controls the first
cells near the causal endpoint. We define a normalized adjoint-energy influence density and derive its exact
evolution along full-batch gradient flow. The adjoint admits an exact generator-term decomposition into residual transmission, nonlocal Volterra, and local channels, including all covariance cross terms. Causal masking can amplify early-position sensitivity and residual identity paths can transmit a right-localized terminal bias, but neither mechanism alone forces a U-shaped profile. We therefore state boundary advantages under independently checkable energy, correlation, and local-channel bounds; these conditions are sufficient rather than necessary. Finite-
token influence balancing, positional reweighting, and task-aligned observability are presented as diagnostics or regularizers with explicit differentiation requirements, computational costs, and limitations. Controlled simulations illustrate that each intervention controls its designated surrogate, while observability balance or outer-loop reweighting need not monotonically reduce the influence-based Lost-in-the-Middle diagnostic.
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Statistical Methodology
A Globally Calibrated Bayesian Optimal Phase II Design for Adaptive Enrichment Trials
Masahiro Kojima, Hisato Sunami and Masaaki Kuriki
Adaptive enrichment allows development of an experimental treatment to continue when its activity is insufficient in an all-comer population but remains promising in a prespecified biomarker-positive subgroup. However, sequential application of separately calibrated phase II designs can inflate the probability of a false-positive efficacy conclusion. We develop a globally calibrated
Bayesian optimal phase II (BOP2) design for branching adaptive enrichment trials. At prespecified all-comer interim analyses, the trial either continues all-comer enrollment or, after crossing the all-comer futility boundary, evaluates the accumulated biomarker-positive data. Enrichment is initiated only when a prespecified minimum number of biomarker-positive patients is available and the biomarker-positive futility boundary is not crossed; otherwise, the trial stops. The all-comer and biomarker-positive thresholds are jointly calibrated for the union of the two possible efficacy claims while accounting for the random subgroup sample size available when enrichment is considered. All decision rules are prespecified before trial initiation. For a binary endpoint, an exact finite-state recursive enumeration enables calibration and operating-characteristic evaluation without Monte Carlo error. Under the prespecified point global null, the proposed design controlled the global type I error rate over the prespecified set of biomarker-positive prevalence values while achieving higher power than the independently calibrated BOP2 comparator across the evaluated alternative scenarios. In the numerical study, the independently calibrated comparator exceeded the nominal global type I error level after its components were embedded in the branching procedure. The framework is also extended to complex categorical endpoints using a Dirichlet–multinomial formulation, with calibration and evaluation performed by simulation.
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Statistical Methodology
Fitting the topology of synthetic particle systems with a novel graph representation
Martin Alexander Memmesheimer and Claudia Redenbach
The shape and arrangement of particles in a material determine its macroscopic properties. The generation of synthetic data with varying particle structure, often represented as 3D voxel images, combined with simulation of macroscopic properties reveals structure-property relations. Most particle generation models focus on single-particle characteristics like shape and size. We aim at fitting the
topology of the particle system using tools from persistent homology. However, the large size of the required 3D image data makes existing methods computationally infeasible. We bridge this gap by introducing a novel graph representation of particle systems and transferring the computation of persistent homology from the image domain to the graph domain. This yields a postprocessing method for synthetic images of particle systems, that is independent of the underlying generation method and improves topological and geometrical agreement with real particle systems while preserving morphological characteristics such as the particle size distribution.
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Statistical Methodology
Equality, Equity, and Causality in Fairness Research: A Commentary on Cheng (2026)
Youmi Suk
This is an invited commentary on the Psychometrika focus article "
Fairness Issues and Evaluation in Psychometrics and AI/ML: What Can We Learn from Each Field?" by Ying Cheng (2026, doi:10.1017/psy.2026.10110). Cheng offers a systematic comparison between long-standing test
fairness and modern algorithmic
fairness. Her mapping of the entire testing workflow onto the AI/ML
fairness paradigm, rather than only the final selection stage, is a crucial contribution to interdisciplinary
fairness research. This commentary extends her discussion by examining two conceptual issues: the distinction between equality and equity, and the role of causality in
fairness research. The focus article and this commentary point to directions for future
fairness research across the psychometrics and AI/ML communities.
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Machine Learning (Statistics)
An efficient adaptive dimension selection algorithm for multidimensional probit graded response models
Yu Zhou, Yincai Tang, Bin Lv et al. (+1 more)
Multidimensional graded response models (MGRMs) are widely used for analyzing ordinal questionnaire data in psychological and educational assessments. A central challenge in applying these models is determining the number of latent dimensions. Conventional approaches usually fit multiple fixed-dimensional models and select among them using post-hoc criteria such as AIC, BIC, or cross-validation, which can be computationally demanding and ignore uncertainty in dimensionality during estimation. We develop an adaptive
Bayesian dimension selection framework for probit MGRMs. Building on the cumulative shrinkage process, we assign a cumulative ordered spike-and-slab (COSS) prior to the column-specific variances of the item loading
matrix. This prior induces increasing shrinkage across latent dimensions, allowing redundant dimensions to be shrunk toward zero while preserving flexibility for active dimensions. Albert–Chib latent response augmentation is used to handle the ordinal probit likelihood, yielding conditionally Gaussian updates for item loadings and latent traits. These updates are combined with Gibbs updates for threshold and shrinkage parameters in an efficient adaptive sampler. Simulation studies evaluate the proposed method in terms of dimension recovery, parameter estimation accuracy, and computational efficiency, with comparisons to conventional fixed-dimensional estimation and model selection procedures. The results show that the proposed approach accurately recovers the latent structure while avoiding repeated model fitting over multiple candidate dimensions. We further illustrate the method using real psychological assessment data, demonstrating its practical utility for uncovering interpretable latent structures in ordinal item responses.
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All authors Yu Zhou, Yincai Tang, Bin Lv, Meng Gao
Machine Learning (Statistics) · Cross-listed from cs.LG
Optimizing the Preconditioner: A Black-box Online-to-Nonconvex Conversion with Static Regret Minimization Oracles
Haichen Hu and David Simchi-Levi
Stochastic nonconvex optimization is central to training deep networks and LLMs in modern machine learning. We give a black-box reduction from
stochastic nonconvex optimization to ordinary static regret minimization in online convex optimization (OCO), thereby resolving the open problem posed by Chen and Hazan (2024). Our reduction maintains a predictable gradient tracker, while a black-box online learner $\mathcal{A}$ selects a preconditioner that transforms this tracker into the update direction. Given a \(\beta\)-smooth function with a range bounded by $M$ and an unbiased gradient oracle with variance bounded by $\sigma^2$, we bound the expected average squared gradient norm by $O(\sigma\sqrt{M\beta/T}+\sqrt{M\beta}\mathrm{Reg}_T(\mathcal{A})/T+\frac{M\beta}{T})$, where $\mathrm{Reg}_T(\mathcal{A})$ is the static regret of $\mathcal{A}$. Thus, any OCO oracle with $O(\sqrt{T})$ regret recovers the classical $O(T^{-1/2})$ convergence rate. We further extend the framework to nonsmooth nonconvex objectives, still relying only on ordinary static regret, and attain the optimal convergence rate for Goldstein-type stationarity. Finally, we conduct numerical experiments on nonconvex objectives to illustrate how the reduction exploits online-selected preconditioners while using the same
stochastic-oracle budget as
stochastic gradient descent.
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Statistical Methodology
Spatial Dependence in Directed Preferential-Attachment Networks
Zihan Li and Tiandong Wang
Spatially embedded directed networks, such as airline networks, often exhibit simultaneous high activity at nearby nodes. Preferential attachment (PA) explains hub dominance. We extend it to spatial co-movement through a directed PA model whose out- and in-node weights follow temporally persistent Gaussian-process lognormal fields. Under sublinear PA, out-degree proportions converge to explicit normalized powered weights, whereas self-loop exclusion yields a coupled in-degree limit. We derive a strictly concave inverse that recovers the in-weights from terminal degree proportions. For ordered network histories, we develop a minorization-maximization (MM) weight
estimator and profile likelihood for the PA exponent; temporal pre-whitening and a spatial quasi-likelihood estimate the latent covariance. Simulations verify transmission of distance-decaying dependence and show how random segment volume creates a distance-independent common mode in raw degrees. An analysis of U.S. domestic flights (2015-2019) separates network-wide volume variation from a short-range spatial component. An observed-volume reconstruction reproduces the raw-degree common mode, and the fitted field yields an exploratory co-exceedance transition scale of roughly 150 km. A per-carrier analysis of European air traffic also reveals the same decomposition.
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Statistical Methodology
E-Values For Multiplicity Control In Multiverse Analysis
Paul Rognon-Vael and David Rossell
Multiverse analysis refers to a common situation where one wishes to assess the association between multiple possible treatment definitions and multiple possible outcome definitions, potentially within multiple sub-populations, among other possible analysis specifications. Multiverse analysis is a useful exploratory tool to assess heterogeneity across the considered specifications, but it is sometimes also used to assess statistical significance. In the latter case, it is critical to acknowledge that multiple comparisons are being performed, and to ensure a valid statistical control of false positive findings. We study the use of e-values within generalized linear models as a tool to control the false discovery rate regardless of the dependence structure of the multiple analyses being performed, while accounting for confounding
covariates. We compare the performance of several approaches: universal e-values, soft-rank e-values, and p-to-e calibration. We find that, for problem characteristics typically encountered in multiverse analyses, p-to-e calibration significantly outperforms the other two approaches in terms of statistical power, but said power may be moderate unless the sample size or effect sizes are large enough. An application studying the association between teenager technology use and mental well-being reveals association between depression, low self-steem and peer problems with internet and social media usage.
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Statistical Methodology
Two-stage Adaptive Testing of Large-scale Mediation Hypotheses
Yueqi Xu and Kwun Chuen Gary Chan
In testing large-scale mediation hypotheses, the exposure-mediator and mediator-outcome path-specific p-values obtained for each hypothesis from the same sample can be combined into a pair of asymptotically independent p-values, which can then be used to test a global null hypothesis and a composite mediation null hypothesis, respectively. A first-stage screening procedure targeting the more stringent global null can effectively reduce the number of mediation hypotheses to be tested in the second stage, which in turn reduces the conservativeness of multiple comparison. The framework can incorporate any data-adaptive choice of screening threshold in Stage 1, and any step-up false discovery rate control method in Stage 2. The proposed procedure controls the false discovery rate asymptotically while being consistently well powered across a wide range of scenarios.
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Machine Learning (Statistics) · Cross-listed from cs.LG
Program Synthesis for Simulation-Based Inference: Joint Model Selection and Parameter Estimation
Siddharth Mishra-Sharma
Neural simulation-based inference enables parameter estimation for complex models, but typically requires the user to specify a simulator encoding a fixed model structure. We present a framework for joint model selection and parameter estimation that combines large
language models for program synthesis with neural simulation-based inference. Given a natural
language description of the system and data under investigation, an LLM proposes candidate simulator programs which are iteratively refined via feedback-driven mutation and evaluated using neural density estimation. The approach enables simulation-based inference over a pool of models, not just parameters within a fixed model. On
benchmarks spanning deterministic dynamics,
stochastic epidemic models, and dark matter substructure inference from gravitational-
lensing images, the method identifies plausible model families from open-ended
prompts, with accuracy that reflects the information content of the data and identifiability of candidate models.
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Statistics Theory
On Mixtures of Three Homoscedastic Gaussian Densities: An Unconditional Sharper Bound on the Number of Modes
Akifumi Okuno and Yutaro Kabata
It is known that a mixture of three homoscedastic multivariate Gaussian densities whose centers form an equilateral triangle can have four modes, owing to the emergence of a “ghost” mode at the center. Nevertheless, obtaining a sharp upper bound on the number of modes remains open even in this seemingly simple setting. The best previously available upper bounds applicable to the homoscedastic three-component setting were 42592 and, more recently, 72. These bounds were derived for substantially more general classes of Gaussian mixtures and are therefore not optimized for the present setting. Moreover, they are conditional on the assumption that the modal set is finite. In this paper, as a sharper bound, we prove that every mixture of three homoscedastic Gaussian densities has at most 8 modes, without imposing any finiteness or non-degeneracy assumption a priori. To the best of our knowledge, this is the first unconditional finiteness result for the modal set that holds uniformly over the full class of multivariate three-component homoscedastic Gaussian mixtures. In particular, it covers genuinely multivariate asymmetric configurations with arbitrary non-collinear centers and arbitrary positive mixture weights.
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Statistical Computation
A general framework for computation and estimation using the saddlepoint approximation
Godrick Oketch, Rachel M. Fewster and Jesse Goodman
The saddlepoint approximation provides highly accurate approximations to probability density and mass functions using only the corresponding moment generating functions (MGFs). Recent work has increasingly seen the saddlepoint approximation applied to likelihood functions, enabling likelihood-based inference in models where exact likelihoods are intractable. However, existing implementations have largely been developed on a model-by-model basis, and the methodology remains underutilized because of the conceptual and computational challenges of working with MGFs. We introduce a unified framework for model construction and computation using the saddlepoint approximation. The framework is based on a collection of model-building operations that preserve access to MGFs while allowing complex distributions to be constructed from simpler components. With these components, users need only provide a high-level specification of the model structure, from which the software automatically assembles the necessary generating functions, saddlepoints, and gradients, and performs the optimization of the saddlepoint likelihood. We also introduce a diagnostic that quantifies the difference between saddlepoint and exact likelihood estimates, even when the exact likelihood is unavailable. The framework is implemented in the R package saddlepoint and provides fast, convenient computation of parameter estimates, standard errors, and the discrepancy diagnostic. Numerous examples illustrate the scope and flexibility of the approach.
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Statistical Methodology
Calibrating Semantic Uncertainty from Observable Language-Model Probabilities
Matthew F. Dixon
As generative artificial intelligence enters scientific and professional work, its uncertainty must be defined on the states that matter for inference and decision-making.
Language models assign probabilities to words, whereas applications require uncertainty over meaningful states such as diagnoses, hypotheses or operational conditions. We introduce a semantic map: a prespecified, testable bridge from probabilities over verbal responses to a posterior over declared finite states. The
language distribution remains unrestricted; held-out calibration connects it to a reference posterior. We derive posterior-error bounds and conditions for existence, conditional uniqueness, presentation stability and stable inverse recovery. This distinction matters because
language probabilities depend on
prompt wording, while the target posterior should not change under information-equivalent rewording. Experiments use professional
market text compiled from Federal Reserve economic and financial series, together with controlled simulations having exact posteriors. Across two fitted
language models,
language-derived probabilities outperform printed numerical confidence, recover held-out posteriors with valid uncertainty coverage, remain largely stable under paraphrase and respond appropriately to altered evidence.
Prompt engineering optimises a wording-dependent response; robust scientific use requires validated stability of application-relevant meaning. The proposed map turns semantic uncertainty in generative systems into an identifiable and testable statistical measurement problem and, when its acceptance conditions hold, yields an auditable posterior estimate.
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Machine Learning (Statistics) · Cross-listed from cs.LG
Calibrated Alzheimer's Conversion Risk in Mild Cognitive Impairment: Persistent Homology of Clinical Trajectories with Conformal Guarantees
Navin Bondade
Background. Predicting conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is central to trial enrichment and care planning, yet existing models provide no individual-level uncertainty estimates and rarely include transparent leakage audits. We introduce the first application of persistent homology to longitudinal clinical trajectory point clouds for this task, and the first split-conformal individual risk guarantee for any AD-conversion model. Methods. We analysed 741 MCI subjects (240 converters, 32.4%) from ADNI with a uniform 4-year follow-up cap. Five leakage sources were corrected; without them a naive pipeline achieved AUC=0.934, inflated by +0.075. Vietoris-Rips persistent homology and sublevel-set proxies were combined with trajectory slopes and engineered features (76 total) in a stacking ensemble evaluated by 5-fold cross-validation. Results. Cox and Random Survival Forest models with TDA features achieved concordance C=0.799 and C=0.826 versus C=0.753 and C=0.812 without (+0.045 and +0.014). The primary nested AUC is 0.840 (same-fold bound 0.866); external AUC was 0.879 on a zero-overlap ADNI-2/GO/3 cohort. H0 persistence
entropy was the top SHAP feature and significantly associated with APOE4 dosage (Spearman r=-0.191, p<0.0001, Bonferroni-corrected). Cross-conformal coverage was 90.4%+-2.2% (target 90%); empirical external coverage 96.9%. Maximum
fairness gap in false-negative rate across seven subgroups was 0.092. Conclusions. We propose H0 persistence
entropy as a topological biomarker of cognitive decline and demonstrate that a leakage-audited, conformally calibrated pipeline reaches competitive accuracy with individual-level uncertainty quantification not previously available for this task.
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