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Thursday 26 February

Statistics Theory

How to recover a permutation group amidst errors

We consider the problem of recovering a permutation group $G \leq S_n$ from an error-prone sampling process $X$. We model $X$ as an $S_n$-valued random variable, defined as a mixture of the uniform distributions on $G$ and $S_n$ . Our suite of tools recovers properties of $G$ from $X$ and bolsters our main method for recovering $G$ itself. Our algorithms are motivated by the numerical computation of monodromy groups, a setting where such error-prone sampling procedures occur organically.
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Statistical Methodology · Cross-listed from econ.EM

Testing Hypotheses About Ratios of Linear Trend Slopes in Systems of Equations with a Focus on Tests of Equal Trend Ratios

This paper develops inference methods for ratios of deterministic trend slopes in systems of pairs of time series. Hypotheses based on linear cross-equation restrictions are considered with particular interest in tests that trend ratios are equal across pairs of trending series. Tests of equal ratios can be used for the empirical assessment of climate models through comparisons of trend ratios (amplification ratios) of model generated temperature series and observed temperature series. The analysis in this paper builds on the estimation and inference methods developed by Vogelsang and Nawaz (2017, Journal of Time Series Analysis) for a single pair of trending time series. Because estimators of ratios can have poor finite sample properties when the trend slope are small relative to variation around the trends, tests of equal trend ratios are restated in terms of products of trend slopes leading to inference that is less affected by small trend slopes. Asymptotic theory is developed that can be used to generate critical values. For tests of equal trend ratios, finite sample performance is assessed using simulations. Practical advice is provided for empirical practitioners. An empirical application compares amplification ratios (trend ratios) across a set of five groups of observed global temperature series.
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Machine Learning (Statistics) · Cross-listed from cs.LG

Global Interpretability via Automated Preprocessing: A Framework Inspired by Psychiatric Questionnaires

Psychiatric questionnaires are highly context sensitive and often only weakly predict subsequent symptom severity, which makes the prognostic relationship difficult to learn. Although flexible nonlinear models can improve predictive accuracy, their limited interpretability can erode clinical trust. In fields such as imaging and omics, investigators commonly address visit- and instrument-specific artifacts by extracting stable signal through preprocessing and then fitting an interpretable linear model. We adopt the same strategy for questionnaire data by decoupling preprocessing from prediction: REFINE (Redundancy-Exploiting Follow-up-Informed Nonlinear Enhancement) uses follow-up information to learn a nonlinear, item-aligned preprocessing of baseline measurements, and then maps these stabilized baseline items to future severity through a linear coefficient matrix. This construction constrains where nonlinearity enters rather than restricting the end-to-end predictive function class, allowing the prognostic relationship to remain globally interpretable through a single coefficient matrix rather than through post hoc local attributions. In the population, the resulting predictor recovers the Bayes-optimal conditional mean, so global linear interpretability does not require sacrificing nonlinear predictive flexibility. In experiments, REFINE outperforms other interpretable approaches while preserving clear global attribution of prognostic factors across psychiatric and non-psychiatric longitudinal prediction tasks.
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Statistical Methodology

Robust model selection using likelihood as data

Model selection is a central task in statistics, but standard methods are not robust in misspecified settings where the true data-generating process (DGP) is not in the set of candidate models. The key limitation is that existing methods – including information criteria and Bayesian posteriors – do not quantify uncertainty about how well each candidate model approximates the true DGP. In this paper, we introduce a novel approach to model selection based on modeling the likelihood values themselves. Specifically, given $K$ candidate models and $n$ observations, we view the $n\times K$ matrix of negative log-likelihood values as a random data matrix and observe that the expectation of each row is equal to the vector of Kullback–Leibler divergences between the $K$ models and the true DGP, up to an additive constant. We use a multivariate normal model to estimate and quantify uncertainty in this expectation, providing calibrated inferences for robust model selection under misspecification. The procedure is easy to compute, interpretable, and comes with theoretical guarantees, including consistency.
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Statistics Theory · Cross-listed from cs.LG

Mean Estimation from Coarse Data: Characterizations and Efficient Algorithms

Coarse data arise when learners observe only partial information about samples; namely, a set containing the sample rather than its exact value. This occurs naturally through measurement rounding, sensor limitations, and lag in economic systems. We study Gaussian mean estimation from coarse data, where each true sample $x$ is drawn from a $d$-dimensional Gaussian distribution with identity covariance, but is revealed only through the set of a partition containing $x$. When the coarse samples, roughly speaking, have “low” information, the mean cannot be uniquely recovered from observed samples (i.e., the problem is not identifiable). Recent work by Fotakis, Kalavasis, Kontonis, and Tzamos [FKKT21] established that sample-efficient mean estimation is possible when the unknown mean is identifiable and the partition consists of only convex sets. Moreover, they showed that without convexity, mean estimation becomes NP-hard. However, two fundamental questions remained open: (1) When is the mean identifiable under convex partitions? (2) Is computationally efficient estimation possible under identifiability and convex partitions? This work resolves both questions. [...]
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All authors Alkis Kalavasis, Anay Mehrotra, Manolis Zampetakis, Felix Zhou, Ziyu Zhu

Machine Learning (Statistics) · Cross-listed from cs.LG

Differentiable Zero-One Loss via Hypersimplex Projections

Recent advances in machine learning have emphasized the integration of structured optimization components into end-to-end differentiable models, enabling richer inductive biases and tighter alignment with task-specific objectives. In this work, we introduce a novel differentiable approximation to the zero-one loss-long considered the gold standard for classification performance, yet incompatible with gradient-based optimization due to its non-differentiability. Our method constructs a smooth, order-preserving projection onto the n,k-dimensional hypersimplex through a constrained optimization framework, leading to a new operator we term Soft-Binary-Argmax. After deriving its mathematical properties, we show how its Jacobian can be efficiently computed and integrated into binary and multiclass learning systems. Empirically, our approach achieves significant improvements in generalization under large-batch training by imposing geometric consistency constraints on the output logits, thereby narrowing the performance gap traditionally observed in large-batch training.
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Statistical Methodology

Data-Efficient Generative Modeling of Non-Gaussian Global Climate Fields via Scalable Composite Transformations

Quantifying uncertainty in climate-model output requires characterizing internal variability, often through large ensembles of physical climate-model runs. Since each additional ensemble member is computationally expensive, only limited numbers of replicated fields are typically available under a fixed model configuration and forcing scenario. We propose a data-efficient stochastic generator for the internal variability of global climate fields, specifically designed to overcome these sample-size constraints. The framework targets the distribution of climate-model output under fixed forcing and model physics. Inspired by copula modeling, our approach constructs a highly expressive joint distribution via a composite transformation to a multivariate standard normal space. We combine a nonparametric Bayesian transport map for spatial dependence modeling with flexible, spatially varying marginal models, essential for capturing non-Gaussian behavior and heavy-tailed extremes. These marginals are defined by a parametric model followed by a semi-parametric B-spline correction to capture complex distributional features. The marginal parameters are spatially smoothed using Gaussian-process priors with low-rank approximations, rendering the computational cost linear in the spatial dimension. When applied to global log-precipitation-rate fields under fixed forcing at more than 50,000 grid locations, our stochastic surrogate achieves high fidelity, accurately quantifying the climate distribution's spatial dependence and marginal characteristics, including the tails. Using only 10 training fields, it outperforms a state-of-the-art competitor trained on 80 fields, effectively octupling the computational budget for climate research. We provide a Python implementation at https://github.com/jobrachem/ppptm .
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Statistical Methodology

Identifiability of Treatment Effects with Unobserved Spatially Varying Confounders

The study of causal effects in the presence of unmeasured spatially varying confounders has garnered increasing attention. However, a general framework for identifiability, which is critical for reliable causal inference from observational data, has yet to be advanced. In this paper, we study a linear model with various parametric model assumptions on the covariance structure between the unmeasured confounder and the exposure of interest. We establish identifiability of the treatment effect for many commonly 20 used spatial models for both discrete and continuous data, under mild conditions on the structure of observation locations and the exposure-confounder association. We also emphasize models or scenarios where identifiability may not hold, under which statistical inference should be conducted with caution.
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Statistical Methodology

Randomization Tests in Switchback Experiments

Switchback experiments assign an experimental unit, such as a market or a platform, to treatment or control over successive blocks of time. Inference can be challenging because these experiments often contain only a small number of randomized blocks, while outcomes may exhibit serial dependence, seasonality, and treatment effects that persist across periods. We develop a conditional randomization test for the null of no total treatment effect that is finite-sample valid under standard assumptions on temporal interference without requiring a parametric model for outcomes. We also develop randomization tests for these assumptions: a carryover test that assesses whether past assignments continue to affect outcomes beyond a prespecified horizon and a non-anticipation test that assesses whether future assignments affect current outcomes. For hypotheses about average treatment effects, we establish asymptotic validity of studentized randomization tests under additional regularity conditions. Finally, we derive power approximations and characterize the tradeoffs between experimental design choices, the number of informative randomized comparisons, and statistical power. Numerical experiments with stylized potential outcomes and a dynamic rideshare model illustrate finite-sample performance and implications for experimental design.
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Statistics Applications

The Counterfactual Combine: A Causal Framework for Player Evaluation

Evaluating sports players based on their performance shares core challenges with evaluating healthcare providers based on patient outcomes. Drawing on recent advances in healthcare provider profiling, we cast sports player evaluation within a rigorous causal inference framework and define a flexible class of causal player evaluation estimands. Using stochastic interventions, we compare player success rates on repeated tasks (such as field goal attempts or plate appearance) to counterfactual success rates had those same attempts been randomly reassigned to players according to prespecified reference distributions. This setup encompasses direct and indirect standardization parameters familiar from healthcare provider profiling, and we additionally propose a "performance above random replacement" estimand designed for interpretability in sports settings. We develop doubly robust estimators for these evaluation metrics based on modern semiparametric statistical methods, with a focus on Targeted Minimum Loss-based Estimation, and incorporate machine learning methods to capture complex relationships driving player performance. We illustrate our framework in detailed case studies of field goal kickers in the National Football League and batters in Major League Baseball, highlighting how different causal estimands yield distinct interpretations and insights about player performance.
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Machine Learning (Statistics) · Cross-listed from cs.CL

Fine-Tuning Without Forgetting In-Context Learning: A Theoretical Analysis of Linear Attention Models

Transformer-based large language models exhibit in-context learning, enabling adaptation to downstream tasks via few-shot prompting with demonstrations. In practice, such models are often fine-tuned to improve zero-shot performance on downstream tasks, allowing them to solve tasks without examples and thereby reducing inference costs. However, fine-tuning can degrade in-context learning, limiting the performance of fine-tuned models on tasks not seen during fine-tuning. Using linear attention models, we provide a theoretical analysis that characterizes how fine-tuning objectives modify attention parameters and identifies conditions under which this leads to degraded few-shot performance. We show that fine-tuning all attention parameters can harm in-context learning, whereas restricting updates to the value matrix improves zero-shot performance while preserving in-context learning. We further show that incorporating an auxiliary few-shot loss enhances in-context learning primarily on the target task, at the expense of degraded in-context learning ability on tasks not seen during fine-tuning. We provide empirical evidence from synthetic and real-world datasets consistent with the qualitative predictions of our theory.
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Statistics Theory · Cross-listed from math.CA

High-dimensional Laplace asymptotics up to the concentration threshold

We study high-dimensional Laplace-type integrals $I(\lambda):=(\lambda/2\pi)^{d/2}\int_{\mathbb R^d} g(x)e^{-\lambda f(x)}dx$ in the regime where both $d$ and $\lambda$ are large. Existing rigorous Laplace-expansion results in growing dimension are largely confined to the "Gaussian-approximation" regime $d^2/\lambda\to0$, which excludes many practically relevant settings that lie beyond this threshold but still satisfy the concentration condition $d/\lambda\to0$. We close this gap by deriving an explicit asymptotic expansion for $\log I(\lambda)$ with quantitative remainder bounds that remain valid throughout this intermediate region, arbitrarily close to the concentration threshold. Fix $L\ge1$ and assume that, in a neighborhood of the global minimizer of $f$, the operator norms of derivatives of $f$ and $g$ are bounded independently of $d,\lambda$ up to orders $2L+2$ and $2L$, respectively. Assuming also some mild global growth conditions, we prove $$\log I(\lambda)=\sum_{k=1}^{L-1} b_k(f,g)\lambda^{-k}+O(d^{L+1}/\lambda^L), \qquad d^{L+1}/\lambda^L\to0,$$ with coefficients satisfying $b_k(f,g)=O(d^{k+1})$. Moreover, the $b_k(f,g)$ coincide with the coefficients from the formal cumulant expansion of $\log I(\lambda)$. We also study computation for concentrating densities $\pi(x)\propto e^{-\lambda f(x)}$. For smooth observables $g$, our expansion yields closed-form, analytic approximations of $\mathbb E_{X\sim\pi}[g(X)]$. For sampling, we construct explicit polynomial transports $x_L$ such that $\pi_L:=(x_L)_\# N(0,\lambda^{-1}I_d)$ satisfies $\mathrm{TV}(\pi,\pi_L)\lesssim d^{L+1}/\lambda^L$ for $L=1,2,3,\dots$, yielding an accurate procedure arbitrarily close to the concentration threshold $d=o(\lambda)$.
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Statistical Methodology

Dimension Reduction in Multivariate Extremes via Latent Linear Factor Models

We propose a new and interpretable class of high-dimensional tail dependence models based on latent linear factor structures. Specifically, extremal dependence of an observable vector is assumed to be driven by a lower-dimensional latent $K$-factor model, where $K \ll d$, thereby inducing an explicit form of dimension reduction. Geometrically, this is reflected in the support of the associated spectral dependence measure, whose intrinsic dimension is at most $K-1$. The loading structure may additionally exhibit sparsity, meaning that each component is influenced by only a small number of latent factors, which further enhances interpretability and scalability. Under mild structural assumptions, we establish identifiability of the model parameters and provide a constructive recovery procedure based on a margin-free tail pairwise dependence matrix, which also yields practical rank-based estimation methods. The framework combines naturally with marginal tail models and is particularly well suited to high-dimensional settings. We illustrate its applicability in a spatial wind energy application, where the latent factor structure enables tractable estimation of the risk that a large proportion of turbines simultaneously fall below their cut-in wind speed thresholds.
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Statistics Applications · Cross-listed from physics.data-an

Titanic overconfidence – dark uncertainty can sink hybrid metrology for semiconductor manufacturing

Hybrid metrology for semiconductor manufacturing is on a collision course with dark uncertainty. An IEEE technology roadmap for this venture has targeted a linewidth uncertainty of +/- 0.17 nm at 95 % coverage and advised the hybridization of results from different measurement methods to hit this target. Related studies have applied statistical models that require consistent results to compel a lower uncertainty, whereas inconsistent results are prevalent. We illuminate this lurking issue, studying how standard methods of uncertainty evaluation fail to account for the causes and effects of dark uncertainty. We revisit a comparison of imaging and scattering methods to measure linewidths of approximately 13 nm, applying contrasting statistical models to highlight the potential effect of dark uncertainty on hybrid metrology. A random effects model allows the combination of inconsistent results, accounting for dark uncertainty and estimating a total uncertainty of +/- 0.8 nm at 95 % coverage. In contrast, a common mean model requires consistent results for combination, ignoring dark uncertainty and underestimating the total uncertainty by as much as a factor of five. To avoid such titanic overconfidence, which can sink a venture, we outline good practices to reduce dark uncertainty and guide the combination of indeterminately consistent results.
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All authors Ronald G. Dixson, Adam L. Pintar, R. Joseph. Kline, Thomas A. Germer, J. Alexander Liddle, John S. Villarrubia, Samuel M. Stavis

Machine Learning (Statistics) · Cross-listed from cs.LG

Provably Efficient Regularized Online RLHF with Generalized Bilinear Preferences

We consider the problem of regularized best-response max-regret minimization in online RLHF under general preferences and bandit feedback. While various regularizers are utilized to robustify alignment, known polylogarithmic regret guarantees remain heavily specific to KL. To investigate whether such fast rates extend beyond KL, we adopt the Generalized Bilinear Preference Model (GBPM) – capturing intransitive preferences over $d$-dimensional item-wise features via a rank-$2r$ skew-symmetric matrix – to isolate the impact of generic regularization. Crucially, under GBPM, we prove that the dual gap of any greedy policy is bounded by the squared estimation error, derived using only strong convexity and skew-symmetry. Under a feature coverage assumption, we establish a generic polylogarithmic regret of $\tilde{\mathcal{O}}(\eta d^4 C_{\min}^{-1} (\log T)^2 \wedge d^2 C_{\min}^{-1/2} \sqrt{T})$ with Greedy Sampling, and a dimension-wise improved regret (for well-conditioned arm-sets) of $\tilde{\mathcal{O}}(C_{\min}^{-2} \sqrt{\eta r T} \wedge r^{1/3} C_{\min}^{-4/3} T^{2/3})$ with Explore-Then-Commit, where $\eta^{-1}$ is the regularization coefficient, $T$ is the time horizon, and $C_{\min}$ is an arm-set dependent quantity. This demonstrates that “fast” regrets are not KL-specific, but rather a fundamental consequence of generic strongly convex geometry.
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All authors Junghyun Lee, Minju Hong, Kwang-Sung Jun, Chulhee Yun, Se-Young Yun

Statistics Theory

Accelerated Online Risk-Averse Policy Evaluation in POMDPs with Theoretical Guarantees and Novel CVaR Bounds

Risk-averse decision-making under uncertainty in partially observable domains is a central challenge in artificial intelligence and is essential for developing reliable autonomous agents. The formal framework for such problems is the partially observable Markov decision process (POMDP), where risk sensitivity is introduced through a risk measure applied to the value function, with Conditional Value-at-Risk (CVaR) being a particularly significant criterion. However, solving POMDPs is computationally intractable in general, and approximate methods rely on computationally expensive simulations of future agent trajectories. This work introduces a theoretical framework for accelerating CVaR value function evaluation in POMDPs with formal performance guarantees. We derive new bounds on the CVaR of a random variable X using an auxiliary random variable Y, under assumptions relating their cumulative distribution and density functions; these bounds yield interpretable concentration inequalities and converge as the distributional discrepancy vanishes. Building on this, we establish upper and lower bounds on the CVaR value function computable from a simplified belief-MDP, accommodating general simplifications of the transition dynamics. We develop estimators for these bounds within a particle-belief MDP framework with probabilistic guarantees, and employ them for acceleration via action elimination: actions whose bounds indicate suboptimality under the simplified model are safely discarded while ensuring consistency with the original POMDP. Empirical evaluation across multiple POMDP domains confirms that the bounds reliably separate safe from dangerous policies while achieving substantial computational speedups under the simplified model.
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Statistical Methodology

Semiparametric Joint Inference for Sensitivity and Specificity at the Youden-Optimal Cut-Off

Sensitivity and specificity evaluated at an optimal diagnostic cut-off are fundamental measures of classification accuracy when continuous biomarkers are used for disease diagnosis. Joint inference for these quantities is challenging because their estimators are evaluated at a common, data-driven threshold estimated from both diseased and healthy samples, inducing statistical dependence. Existing approaches are largely based on parametric assumptions or fully nonparametric procedures, which may be sensitive to model misspecification or lack efficiency in moderate samples. We propose a semiparametric framework for joint inference on sensitivity and specificity at the Youden-optimal cut-off under the density ratio model. Using maximum empirical likelihood, we derive estimators of the optimal threshold and the corresponding sensitivity and specificity, and establish their joint asymptotic normality. This leads to Wald-type and range-preserving logit-transformed confidence regions. Simulation studies show that the proposed method achieves accurate coverage with improved efficiency relative to existing parametric and nonparametric alternatives across a variety of distributional settings. An analysis of COVID-19 antibody data demonstrates the practical advantages of the proposed approach for diagnostic decision-making.
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All authors Siyan Liu, Qinglong Tian, Chunlin Wang, Pengfei Li

Statistics Theory

Low-degree Lower bounds for clustering in moderate dimension

We study the fundamental problem of clustering $n$ points into $K$ groups drawn from a mixture of isotropic Gaussians in $\mathbb{R}^d$. Specifically, we investigate the requisite minimal distance $\Delta$ between mean vectors to partially recover the underlying partition. While the minimax-optimal threshold for $\Delta$ is well-established, a significant gap exists between this information-theoretic limit and the performance of known polynomial-time procedures. Although this gap was recently characterized in the high-dimensional regime ($n \leq dK$), it remains largely unexplored in the moderate-dimensional regime ($n \geq dK$). In this manuscript, we address this regime by establishing a new low-degree polynomial lower bound for the moderate-dimensional case when $d \geq K$. We show that while the difficulty of clustering for $n \leq dK$ is primarily driven by dimension reduction and spectral methods, the moderate-dimensional regime involves more delicate phenomena leading to a "non-parametric rate". We provide a novel non-spectral algorithm matching this rate, shedding new light on the computational limits of the clustering problem in moderate dimension.
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Statistics Theory

On the errors committed by sequences of estimator functionals

Consider a sequence of estimators $\hat \theta_n$ which converges almost surely to $\theta_0$ as the sample size $n$ tends to infinity. Under weak smoothness conditions, we identify the asymptotic limit of the last time $\hat \theta_n$ is further than $\eps$ away from $\theta_0$ when $\eps \rightarrow 0^+$. These limits lead to the construction of sequentially fixed width confidence regions for which we find analytic approximations. The smoothness conditions we impose is that $\hat \theta_n$ is to be close to a Hadamard-differentiable functional of the empirical distribution, an assumption valid for a large class of widely used statistical estimators. Similar results were derived in Hjort and Fenstad (1992, Annals of Statistics) for the case of Euclidean parameter spaces; part of the present contribution is to lift these results to situations involving parameter functionals. The apparatus we develop is also used to derive appropriate limit distributions of other quantities related to the far tail of an almost surely convergent sequence of estimators, like the number of times the estimator is more than $\eps$ away from its target. We illustrate our results by giving a new sequential simultaneous confidence set for the cumulative hazard function based on the Nelson–Aalen estimator and investigate a problem in stochastic programming related to computational complexity.
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2602.23021 · 26 Feb · 27 pages, 1 figure. Statistical Research Report, Department of Mathematics, University of Oslo, from March 2010, now arXiv'd February 2026. The paper is published, essentially in this form, in Mathematical Methods of Statistics, 2012, vol. 20, pages 327-346, at this url: link.springer.com/article/10.3103/S106653071104003X

Statistical Methodology

Testing Partially-Identifiable Causal Queries Using Ternary Tests

We consider hypothesis testing of binary causal queries using observational data. Since the mapping of causal models to the observational distribution that they induce is not one-to-one, in general, causal queries are often only partially identifiable. When binary statistical tests are used for testing partially-identifiable causal queries, their results do not translate in a straightforward manner to the causal hypothesis testing problem. We propose using ternary (three-outcome) statistical tests to test partially-identifiable causal queries. We establish testability requirements that ternary tests must satisfy in terms of uniform consistency and present equivalent topological conditions on the hypotheses. To leverage the existing toolbox of binary tests, we prove that obtaining ternary tests by combining binary tests is complete. Finally, we demonstrate how topological conditions serve as a guide to construct ternary tests for two concrete causal hypothesis testing problems, namely testing the instrumental variable (IV) inequalities and comparing treatment efficacy.
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All authors Sourbh Bhadane, Joris M. Mooij, Philip Boeken, Onno Zoeter

Machine Learning (Statistics)

Regular Fourier Features for Nonstationary Gaussian Processes

Simulating a Gaussian process requires sampling from a high-dimensional Gaussian distribution, which scales cubically with the number of sample locations. Spectral methods address this challenge by exploiting the Fourier representation and treating the spectral density as a probability distribution suitable for Monte Carlo approximation. Although this probabilistic interpretation is valid for stationary processes, it is overly restrictive for the nonstationary case, where spectral densities are generally not probability measures. To avoid this limitation, we propose regular Fourier features for harmonizable processes with one-dimensional inputs. Our method discretizes the spectral representation directly, preserving the correlation structure among spectral weights without requiring probability assumptions. Assuming finite spectral support, this yields an efficient low-rank approximation that is positive semi-definite by construction and consistent under mild regularity conditions. When the spectral density is unknown, the framework also extends to kernel learning from data, which we explore as a proof of concept. We demonstrate the approximation on locally stationary and harmonizable mixture kernels, the latter with a complex-valued spectral density. As a feasibility study, we then apply the kernel-learning extension to real and synthetic data, where it matches competitive baselines.
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Machine Learning (Statistics)

Kernel Integrated $R^2$: A Measure of Dependence

We introduce kernel integrated $R^2$, a new measure of statistical dependence that combines the local normalization principle of the recently introduced integrated $R^2$ with the flexibility of reproducing kernel Hilbert spaces (RKHSs). The proposed measure extends integrated $R^2$ from scalar responses to responses taking values on general spaces equipped with a characteristic kernel, allowing to measure dependence of multivariate, functional, and structured data, while remaining sensitive to tail behaviour and oscillatory dependence structures. We establish that (i) this new measure takes values in $[0,1]$, (ii) equals zero if and only if independence holds, and (iii) equals one if and only if the response is almost surely a measurable function of the covariates. Two estimators are proposed: a graph-based method using $K$-nearest neighbours and an RKHS-based method built on conditional mean embeddings. We prove consistency and derive convergence rates for the graph-based estimator, showing its adaptation to intrinsic dimensionality. Numerical experiments on simulated data and a real data experiment in the context of dependency testing for media annotations demonstrate competitive power against state-of-the-art dependence measures, particularly in settings involving non-linear and structured relationships.
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All authors Pouya Roudaki, Shakeel Gavioli-Akilagun, Florian Kalinke, Mona Azadkia, Zoltán Szabó

Statistical Methodology

permApprox: a general framework for accurate permutation p-value approximation

Permutation procedures are common practice in hypothesis testing when distributional assumptions about the test statistic are not met or unknown. With only few permutations, empirical p-values lie on a coarse grid and may even be zero when the observed test statistic exceeds all permuted values. Such zero p-values are statistically invalid and hinder multiple testing correction. Parametric tail modeling with the Generalized Pareto Distribution (GPD) has been proposed to address this issue, but existing implementations can again yield zero p-values when the estimated shape parameter is negative and the fitted distribution has a finite upper bound. We introduce a method for accurate and zero-free p-value approximation in permutation testing, embedded in the permApprox workflow and R package. Building on GPD tail modeling, the method enforces a support constraint during parameter estimation to ensure valid extrapolation beyond the observed statistic, thereby strictly avoiding zero p-values. The workflow further integrates robust parameter estimation, data-driven threshold selection, and principled handling of hybrid p-values that are discrete in the bulk and continuous in the extreme tail. Extensive simulations using two-sample t-tests and Wilcoxon rank-sum tests show that permApprox produces accurate, robust, and zero-free p-value approximations across a wide range of sample and effect sizes. Applications to single-cell RNA-seq and microbiome data demonstrate its practical utility: permApprox yields smooth and interpretable p-value distributions even with few permutations. By resolving the zero-p-value problem while preserving accuracy and computational efficiency, permApprox enables reliable permutation-based inference in high-dimensional and computationally intensive settings.
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All authors Stefanie Peschel, Anne-Laure Boulesteix, Erika von Mutius, Christian L. Müller

Machine Learning (Statistics) · Cross-listed from cs.CE

An automatic counting algorithm for the quantification and uncertainty analysis of the number of microglial cells trainable in small and heterogeneous datasets

Counting immunopositive cells on biological tissues generally requires either manual annotation or (when available) automatic rough systems, for scanning signal surface and intensity in whole slide imaging. In this work, we tackle the problem of counting microglial cells in lumbar spinal cord cross-sections of rats by omitting cell detection and focusing only on the counting task. Manual cell counting is, however, a time-consuming task and additionally entails extensive personnel training. The classic automatic color-based methods roughly inform about the total labeled area and intensity (protein quantification) but do not specifically provide information on cell number. Since the images to be analyzed have a high resolution but a huge amount of pixels contain just noise or artifacts, we first perform a pre-processing generating several filtered images {(providing a tailored, efficient feature extraction)}. Then, we design an automatic kernel counter that is a non-parametric and non-linear method. The proposed scheme can be easily trained in small datasets since, in its basic version, it relies only on one hyper-parameter. However, being non-parametric and non-linear, the proposed algorithm is flexible enough to express all the information contained in rich and heterogeneous datasets as well (providing the maximum overfit if required). Furthermore, the proposed kernel counter also provides uncertainty estimation of the given prediction, and can directly tackle the case of receiving several expert opinions over the same image. Different numerical experiments with artificial and real datasets show very promising results. Related Matlab code is also provided.
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All authors L. Martino, M. M. Garcia, P. S. Paradas, E. Curbelo

Statistical Methodology

A note on the area under the likelihood and the fake evidence for model selection

Improper priors are not allowed for the computation of the Bayesian evidence $Z=p({\bf y})$ (a.k.a., marginal likelihood), since in this case $Z$ is not completely specified due to an arbitrary constant involved in the computation. However, in this work, we remark that they can be employed in a specific type of model selection problem: when we have several (possibly infinite) models belonging to the same parametric family (i.e., for tuning parameters of a parametric model). However, the quantities involved in this type of selection cannot be considered as Bayesian evidences: we suggest to use the name “fake evidences” (or “areas under the likelihood” in the case of uniform improper priors). We also show that, in this model selection scenario, using a diffuse prior and increasing its scale parameter asymptotically to infinity, we cannot recover the value of the area under the likelihood, obtained with a uniform improper prior. We first discuss it from a general point of view. Then we provide, as an applicative example, all the details for Bayesian regression models with nonlinear bases, considering two cases: the use of a uniform improper prior and the use of a Gaussian prior, respectively. A numerical experiment is also provided confirming and checking all the previous statements.
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Statistics Theory

Effective sample size approximations as entropy measures

In this work, we analyze alternative effective sample size (ESS) metrics for importance sampling algorithms, and discuss a possible extended range of applications. We show the relationship between the ESS expressions used in the literature and two entropy families, the Rényi and Tsallis entropy. The Rényi entropy is connected to the Huggins-Roy's ESS family introduced in \cite{Huggins15}. We prove that that all the ESS functions included in the Huggins-Roy's family fulfill all the desirable theoretical conditions. We analyzed and remark the connections with several other fields, such as the Hill numbers introduced in ecology, the Gini inequality coefficient employed in economics, and the Gini impurity index used mainly in machine learning, to name a few. Finally, by numerical simulations, we study the performance of different ESS expressions contained in the previous ESS families in terms of approximation of the theoretical ESS definition, and show the application of ESS formulas in a variable selection problem.
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Statistics Theory

Remarks on stationary GARCH processes under heavy tail distributions

Let $(X_n)_{n\in \mathbb Z}$ be a GARCH process with $E(X_0^4)<\infty$, and let $\mu_n$ denote the distribution of $\frac 1{{\sqrt n}}\sum_{i=1}^n [X_i^2-\mathbb E(X_0^2)]$. We derive a numerical approximation of $\mu_n$ when $x_1,...,x_n$ are observed. This yields the derivation of confidence intervals for $\mu= E(X_0^2)$ and we investigate the accuracy of these confidence intervals in comparison with standard ones based on normal approximation. Moreover, when the innovation process has heavy tail distribution, we improve the method using a new resampling method.
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Machine Learning (Statistics)

Beyond NNGP: Large Deviations and Feature Learning in Bayesian Neural Networks

We study wide Bayesian neural networks focusing on the rare but statistically dominant fluctuations that govern posterior concentration, beyond Gaussian-process limits. Large-deviation theory provides explicit variational objectives-rate functions-on predictors, providing an emerging notion of complexity and feature learning directly at the functional level. We show that the posterior output rate function is obtained by a joint optimization over predictors and internal kernels, in contrast with fixed-kernel (NNGP) theory. Numerical experiments demonstrate that the resulting predictions accurately describe finite-width behavior for moderately sized networks, capturing non-Gaussian tails, posterior deformation, and data-dependent kernel selection effects.
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Machine Learning (Statistics)

Unsupervised Continual Learning for Amortized Bayesian Inference

Amortized Bayesian Inference (ABI) enables efficient posterior estimation using generative neural networks trained on simulated data, but often suffers from performance degradation under model misspecification. While self-consistency (SC) training on unlabeled empirical data can enhance network robustness, current approaches are limited to static, single-task settings and fail to handle sequentially arriving data or distribution shifts. We propose a continual learning framework for ABI that decouples simulation-based pre-training from unsupervised sequential SC fine-tuning on real-world data. To address the challenge of catastrophic forgetting, we introduce two adaptation strategies: (1) SC with episodic replay, utilizing a memory buffer of past observations, and (2) SC with elastic weight consolidation, which regularizes updates to preserve task-critical parameters. Across three diverse case studies, our methods significantly mitigate forgetting and yield posterior estimates that outperform standard simulation-based training, achieving estimates closer to MCMC reference, providing a viable path for trustworthy ABI across a range of different tasks.
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Statistical Methodology

Projection depth for functional data: Practical issues, computation and applications

Statistical analysis of functional data is challenging due to their complex patterns, for which functional depth provides an effective means of reflecting their ordering structure. In this work, we investigate practical aspects of the recently proposed regularized projection depth (RPD), which induces a meaningful ordering of functional data while appropriately accommodating their complex shape features. Specifically, we examine the impact and choice of its tuning parameter, which regulates the degree of effective dimension reduction applied to the data, and propose a random projection-based approach for its efficient computation, supported by theoretical justification. Through comprehensive numerical studies, we explore a wide range of statistical applications of the RPD and demonstrate its particular usefulness in uncovering shape features in functional data analysis. This ability allows us to propose a novel RPD-based outlier detection method, and to demonstrate that the RPD outperforms competing depth-based approaches in tasks such as functional classification and two-sample hypothesis testing.
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