Statistics Applications
Model-Based Clustering of Football Event Sequences: A Marked Spatio-Temporal Point Process Mixture Approach
Koffi Amezouwui, Brigitte Gelein, Matthieu Marbac et al. (+1 more)
We propose a novel mixture model for football event data that clusters entire possessions to reveal their temporal, sequential, and spatial structure. Each mixture component models possessions as marked spatio-temporal point processes: event types follow a finite Markov chain with an absorbing state for ball loss, event times follow a conditional Gamma process to account for dispersion, and spatial locations evolve via truncated Brownian motion. To aid interpretation, we derive summary indicators from model parameters capturing possession speed, number of events, and spatial dynamics. Parameters are estimated through maximum likelihood via Generalized Expectation-Maximization
algorithm. Applied to StatsBomb data from 38 Ligue 1 matches (2020/2021), our approach uncovers distinct defensive possession patterns faced by Stade Rennais. Unlike previous approaches focusing on individual events, our mixture structure enables principled clustering of full possessions, supporting tactical analysis and the future development of realistic virtual training environments.
Read the full abstract ▾
All authors Koffi Amezouwui, Brigitte Gelein, Matthieu Marbac, Anthony Sorel
Statistical Computation
Uncertainty assessment of spatial dynamic microsimulations
Morgane Dumont, Ahmed Alsaloum, Julian Ernst et al. (+2 more)
Spatial dynamic microsimulations probabilistically project geographically referenced units with individual characteristics over time. Like any projection method, their outcomes are inherently uncertain and sensitive to multiple factors. However, such factors are rarely addressed. Applying variance-based sensitivity analysis to both direct and indirect effects within the employment module of the MikroSim model for Germany, we show that commonly considered sources of uncertainty, namely coefficient and parameter uncertainty, are less influential than qualitative modeling choices. Because dynamic microsimulations are inherently complex and are computationally intensive, it is crucial to consider potential factors of uncertainty and their influence on simulation outputs in order to more carefully design simulation setups and better communicate results. We find, that simple summary measures insufficiently capture overall model uncertainty and urge modelers to account for these broader sources when designing microsimulations and their results.
Read the full abstract ▾
All authors Morgane Dumont, Ahmed Alsaloum, Julian Ernst, Jan Weymeirsch, Ralf Münnich
Statistical Methodology
Covariate Adjustment for the Win Odds: Application to Cardiovascular Outcomes Trials
Cyrill Scheidegger, Simon Wandel and Tobias Mütze
Covariate adjustment can enhance precision and power in clinical trials, yet its application to the win odds remains unclear. The win odds is an extension of the win ratio that counts ties as half a win for the treatment and the control group, respectively. In their original form, both the win ratio and the win odds rely on comparing each individual from the treatment group to each individual from the control group in a pairwise manner, and count the number of wins, losses, and ties from these pairwise comparisons. A priori, it is not clear how
covariate adjustment can be implemented for the win odds. To address this, we establish a connection between the win odds and the marginal probabilistic index, a measure for which
covariate adjustment theory is well-developed. Using this connection, we show how
covariate adjustment for the win odds is possible, leading to potentially more precise
estimators and larger power as compared to the unadjusted win odds. We present the underlying theory for
covariate adjustment for the win odds in an accessible way and apply the method on synthetic data based on the CANTOS trial (ClinicalTrials.gov identifier: NCT01327846) characteristics, on a subset of the HF-ACTION trial data (ClinicalTrials.gov identifier: NCT00047437), and on simulated data to study the operating characteristics of the method. We observe that there is indeed a potential gain in power when the win odds is adjusted for baseline
covariates if the baseline
covariates are prognostic for the outcome. This comes at the cost of a slight inflation of the type I error rate for small sample sizes.
Read the full abstract ▾
Machine Learning (Statistics)
Causal Discovery on Higher-Order Interactions
Alessio Zanga, Marco Scutari and Fabio Stella
Causal discovery combines data with knowledge provided by experts to learn the DAG representing the causal relationships between a given set of variables. When data are scarce, bagging is used to measure our confidence in an average DAG obtained by aggregating bootstrapped DAGs. However, the aggregation step has received little
attention from the specialized literature: the average DAG is constructed using only the confidence in the individual edges of the bootstrapped DAGs, thus disregarding complex higher-order edge structures. In this paper, we introduce a novel theoretical framework based on higher-order structures and describe a new DAG aggregation
algorithm. We perform a simulation study, discussing the advantages and limitations of the proposed approach. Our proposal is both computationally efficient and effective, outperforming state-of-the-art solutions, especially in low sample size regimes and under high dimensionality settings.
Read the full abstract ▾
Machine Learning (Statistics)
SCOPE: Spectral Concentration by Distributionally Robust Joint Covariance-Precision Estimation
Renjie Chen, Viet Anh Nguyen and Huifu Xu
We propose a distributionally robust formulation for simultaneously estimating the covariance
matrix and the precision
matrix of a random vector.The proposed model minimizes the worst-case weighted sum of the Frobenius loss of the covariance
estimator and Stein's loss of the precision
matrix estimator against all distributions from an ambiguity set centered at the nominal distribution. The radius of the ambiguity set is measured via convex spectral divergence. We demonstrate that the proposed distributionally robust estimation model can be reduced to a convex optimization problem, thereby yielding quasi-analytical
estimators. The joint
estimators are shown to be nonlinear shrinkage
estimators. The
eigenvalues of the
estimators are shrunk nonlinearly towards a positive scalar, where the scalar is determined by the weight coefficient of the loss terms. By tuning the coefficient carefully, the shrinkage corrects the spectral bias of the empirical covariance/precision
matrix estimator. By this property, we call the proposed joint
estimator the Spectral concentrated COvariance and Precision
matrix Estimator (SCOPE). We demonstrate that the shrinkage effect improves the condition number of the
estimator. We provide a parameter-tuning scheme that adjusts the shrinkage target and intensity that is asymptotically optimal. Numerical experiments on synthetic and real data show that our shrinkage
estimators perform competitively against state-of-the-art
estimators in practical applications.
Read the full abstract ▾
Machine Learning (Statistics) · Cross-listed from cs.LG
Synthetic Survival Control: Extending Synthetic Controls for "When-If" Decision
Jessy Xinyi Han and Devavrat Shah
Estimating causal effects on time-to-event outcomes from observational data is particularly challenging due to censoring, limited sample sizes, and non-random treatment assignment. The need for answering such "when-if" questions–how the timing of an event would change under a specified intervention–commonly arises in real-world settings with heterogeneous treatment adoption and confounding. To address these challenges, we propose Synthetic Survival Control (SSC) to estimate counterfactual hazard trajectories in a panel data setting where multiple units experience potentially different treatments over multiple periods. In such a setting, SSC estimates the counterfactual hazard trajectory for a unit of interest as a weighted combination of the observed trajectories from other units. To provide formal justification, we introduce a panel framework with a low-rank structure for causal survival analysis. Indeed, such a structure naturally arises under classical parametric survival models. Within this framework, for the causal estimand of interest, we establish identification and finite sample guarantees for SSC. We validate our approach using a multi-country clinical
dataset of cancer treatment outcomes, where the staggered introduction of new therapies creates a quasi-experimental setting. Empirically, we find that access to novel treatments is associated with improved survival, as reflected by lower post-intervention hazard trajectories relative to their synthetic counterparts. Given the broad relevance of survival analysis across medicine, economics, and public policy, our framework offers a general and interpretable tool for counterfactual survival inference using observational data.
Read the full abstract ▾
Statistical Methodology
High-Dimensional Covariate-Dependent Discrete Graphical Models and Dynamic Ising Models
Lyndsay Roach, Qiong Li, Nanwei Wang et al. (+1 more)
We propose a
covariate-dependent discrete graphical model for capturing dynamic networks among discrete random variables, allowing the dependence structure among vertices to vary with
covariates. This discrete dynamic network encompasses the dynamic Ising model as a special case. We formulate a likelihood-based approach for parameter estimation and statistical inference. We achieve efficient parameter estimation in high-dimensional settings through the use of the pseudo-likelihood method. To perform model selection, a birth-and-death Markov chain Monte Carlo
algorithm is proposed to explore the model space and select the most suitable model.
Read the full abstract ▾
All authors Lyndsay Roach, Qiong Li, Nanwei Wang, Xin Gao
Statistical Methodology
The Prevalence of Misreporting and Misinterpreting Correlation Coefficients in Biomedical Literature
Jiayang Xu, Xintong Chen, Yufeng Liu et al. (+2 more)
Correlation coefficient is widely used in biomedical and biological literature, yet its frequent misuse and misinterpretation undermine the credibility and reproducibility of the scientific findings. We systematically reviewed 1326 records of correlation analyses across 310 articles published in Science, Nature, and Nature Neuroscience in 2022. Our analysis revealed a troubling pattern of poor statistical reporting and inferring: 58.71% (95% CI: [53.23%, 64.19%], 182/310) of studies did not explicitly report sample sizes, and 98.06% (95% CI: [96.53%, 99.60%], 304/310) failed to provide confidence intervals for correlation coefficients. Among 177 articles inferring correlation strength, 45.25% (95% CI: [38.42%, 53.10%], 81/177) relied solely on point estimates, while 53.63% (95% CI: [46.90%, 61.58%], 96/177) drew conclusions based on null hypothesis significance testing. This widespread omission and misuse highlight a systematic gap in both statistic literacy and editorial standards. We advocate clear reporting guidelines mandating effect sizes and confidence intervals in correlation analyses to enhance the transparency, rigor, and reproducibility of quantitative life sciences research.
Read the full abstract ▾
All authors Jiayang Xu, Xintong Chen, Yufeng Liu, Xiaoli Guo, Shanbao Tong
Statistical Methodology
State-Space Representation of INGARCH Models and Their Application in Insurance
Jae Youn Ahn, Hong Beng Lim and Mario V. Wüthrich
Integer-valued generalized autoregressive conditional heteroskedastic (INGARCH) models are a popular framework for modeling serial dependence in count time-series. While convenient for modeling, prediction, and estimation, INGARCH models lack a clear theoretical justification for the
evolution step. This limitation not only makes interpretation difficult and complicates the inclusion of
covariates, but can also make the handling of missing data computationally burdensome. Consequently, applying such models in an insurance context, where
covariates and missing observations are common, can be challenging. In this paper, we first introduce the marginalized state-space model (M-SSM), defined solely through the marginal distribution of the observations, and show that INGARCH models arise as special cases of this framework. The M-SSM formulation facilitates the natural incorporation of
covariates and missing data mechanisms, and this representation in turn provides a coherent way to incorporate these elements within the INGARCH model as well. We then demonstrate that an M-SSM can admit an observation-driven state-space model (O-SSM) representation when suitable assumptions are imposed on the
evolution of its conditional mean. This lifting from an M-SSM to an O-SSM provides a natural setting for establishing weak stationarity, even in the presence of heterogeneity and missing observations. The proposed ideas are illustrated through the Poisson and the Negative-Binomial INGARCH(1,1) models, highlighting their applicability in predictive analysis for insurance data.
Read the full abstract ▾
Statistical Methodology · Cross-listed from cs.LG
CafeMed: Causal Attention Fusion Enhanced Medication Recommendation
Kelin Ren, Chan-Yang Ju and Dong-Ho Lee
Medication recommendation systems play a crucial role in assisting clinicians with personalized treatment decisions. While existing approaches have made significant progress in learning medication representations, they suffer from two fundamental limitations: (i) treating medical entities as independent features without modeling their synergistic effects on medication selection; (ii) employing static causal relationships that fail to adapt to patient-specific contexts and health states. To address these challenges, we propose CafeMed, a framework that integrates dynamic causal
reasoning with cross-modal
attention for safe and accurate medication recommendation. CafeMed introduces two key components: the Causal Weight Generator (CWG) that transforms static causal effects into dynamic modulation weights based on individual patient states, and the Channel Harmonized
Attention Refinement Module (CHARM) that captures complex interdependencies between diagnoses and procedures. This design enables CafeMed to model how different medical conditions jointly influence treatment decisions while maintaining medication safety constraints. Extensive experiments on MIMIC-III and MIMIC-IV
datasets demonstrate that CafeMed significantly outperforms state-of-the-art baselines, achieving superior accuracy in medication prediction while maintaining the lower drug–drug interaction rates. Our results indicate that incorporating dynamic causal relationships and cross-modal synergies leads to more clinically-aligned and personalized medication recommendations. Our code is released publicly at https://github.com/rkl71/CafeMed.
Read the full abstract ▾
Machine Learning (Statistics) · Cross-listed from cs.LG
Radial Compensation: The Inverse Base-Distribution Problem for Chart-Based Generative Models on Riemannian Manifolds
Marios Papamichalis and Regina Ruane
Latent-variable models on spheres and
hyperbolic spaces usually draw a Gaussian in the tangent space at a base point and push it onto the
manifold. On these spaces the distance from the base point is the coordinate that carries meaning: depth in a hierarchy, the angle of a rotation, the deviation of a
protein frame from a reference. We show that the standard construction silently replaces whatever distance distribution the modeler intended with a fixed one, a scaled chi law whose shape no setting of the scale can change. We then solve the reverse problem. Given the intended distance distribution, we derive in closed form the tangent density that realizes it, prove it is the only isotropic choice with chart-independent likelihoods for a broad class of charts, and prove a lower bound with explicit constants on what ignoring the problem costs a variational autoencoder. Experiments backed by an exact per-run normalization audit confirm that the compensated prior is invariant to the chart and stable across scales, every wrapped baseline we train collapses to the boundary of its chart,
curvature becomes recoverable where the wrapped prior fails and
protein-orientation likelihood improves from 2.58 to 0.87 nats at identical accuracy.
Read the full abstract ▾
Statistics Applications · Cross-listed from cs.AI
Making Evidence Actionable in Adaptive Learning
Amirreza Mehrabi, Jason W. Morphew, Breejha Quezada et al. (+1 more)
Adaptive learning often diagnoses precisely yet intervenes weakly, yielding help that is mistimed or misaligned. This study presents evidence supporting an instructor-governed feedback loop that converts concept-level assessment evidence into vetted micro-interventions. The adaptive learning
algorithm contains three safeguards: adequacy as a hard guarantee of gap closure,
attention as a budgeted constraint for time and redundancy, and diversity as protection against overfitting to a single resource. We formalize intervention assignment as a binary integer program with constraints for coverage, time, difficulty windows informed by ability estimates, prerequisites encoded by a concept
matrix, and anti-redundancy enforced through diversity. Greedy selection serves low-richness and tight-latency regimes, gradient-based relaxation serves rich repositories, and a hybrid method transitions along a richness-latency frontier. In simulation and in an introductory physics deployment with one thousand two hundred four students, both solvers achieved full skill coverage for essentially all learners within bounded watch time. The gradient-based method reduced redundant coverage by approximately twelve percentage points relative to greedy and harmonized difficulty across slates, while greedy delivered comparable adequacy with lower computational cost in scarce settings. Slack variables localized missing content and supported targeted curation, sustaining sufficiency across subgroups. The result is a tractable and auditable controller that closes the diagnostic-pedagogical loop and delivers equitable, load-aware personalization at classroom scale.
Read the full abstract ▾
All authors Amirreza Mehrabi, Jason W. Morphew, Breejha Quezada, N. Sanjay Rebello
Machine Learning (Statistics) · Cross-listed from cs.LG
SmallML: Bayesian Transfer Learning for Small-Data Predictive Analytics
Semen Leontev
Small and medium-sized enterprises (SMEs) represent 99.9% of U.S. businesses yet remain systematically excluded from AI due to a mismatch between their operational scale and modern machine learning's data requirements. This paper introduces SmallML, a
Bayesian transfer learning framework achieving enterprise-level prediction accuracy with
datasets as small as 50-200 observations. We develop a three-layer architecture integrating transfer learning, hierarchical
Bayesian modeling, and conformal prediction. Layer 1 extracts informative priors from 22,673 public records using a SHAP-based procedure transferring knowledge from gradient boosting to logistic regression. Layer 2 implements hierarchical pooling across J=5-50 SMEs with adaptive shrinkage, balancing population patterns with entity-specific characteristics. Layer 3 provides conformal sets with finite-sample coverage guarantees P(y in C(x)) >= 1-alpha for distribution-free uncertainty quantification. Validation on customer churn data demonstrates 96.7% +/- 4.2% AUC with 100 observations per business – a +24.2 point improvement over independent logistic regression (72.5% +/- 8.1%), with p < 0.000001. Conformal prediction achieves 92% empirical coverage at 90% target. Training completes in 33 minutes on standard CPU hardware. By enabling enterprise-grade predictions for 33 million U.S. SMEs previously excluded from machine learning, SmallML addresses a critical gap in AI democratization. Keywords:
Bayesian transfer learning, hierarchical models, conformal prediction, small-data analytics, SME machine learning
Read the full abstract ▾
Machine Learning (Statistics)
Splat Regression Models
Mara Daniels and Philippe Rigollet
We introduce a highly expressive class of function approximators called Splat Regression Models. Model outputs are mixtures of heterogeneous and anisotropic bump functions, termed splats, each weighted by an output vector. The power of splat modeling lies in its ability to locally adjust the scale and direction of each splat, achieving both high interpretability and accuracy. Fitting splat models reduces to optimization over the space of mixing measures, which can be implemented using Wasserstein-Fisher-Rao gradient flows. As a byproduct, we recover the popular Gaussian Splatting methodology as a special case, providing a unified theoretical framework for this state-of-the-art technique that clearly disambiguates the inverse problem, the model, and the optimization
algorithm. Through numerical experiments, we demonstrate that the resulting models and
algorithms constitute a flexible and promising approach for solving diverse approximation, estimation, and inverse problems involving low-dimensional data.
Read the full abstract ▾
Statistics Applications
Waiting for Dabo: A machine learning model for predicting Power 4 college football coaching hire success
Michael Schuckers and Austin Hayes
Using data on 103 recent P4 college football hires, we built a statistical model for predicting a coach's success at their new school. For each hire, we collected data about their background and experiences, the previous success as a head coach or coordinator and their success since hiring. Over 50 variables on these factors were recorded though we used 29 of these in building our predictive model. Our measure of success is based upon Bill Connelly's SP+ team ratings relative to the performance on the same metric of the school in the 15 year prior to their selection as head coach. Using a cross-validated regularized linear regression, we obtain a predictive model for coaching success. Among the important factors for predicting a successful hire are having been a previous college head coach, leaving a job as an Offensive Coordinator, age and quality of the hiring school's team in the previous 15 years. While we do find these factors are important for the prediction of a successful coaching hire, the trends here are weak. With 66% accuracy, the model does identify coaching hires that will outperform team performance in the 15 years before the hire. However, no combination of these factors leads to high predictability of identifying a successful coaching hire. All of the data and code for this paper are available in a Github repository.
Read the full abstract ▾