Statistics Applications
Kumaraswamy-Teissier Distribution: Bayesian and Non-Bayesian Inference, Regression Modeling and Climate Application
Kamana Mishra, Neeraj Poonia, Tanmay Kayal et al. (+1 more)
This study introduces the three-parameter Kumaraswamy–Teissier distribution (KTD) by applying the Kumaraswamy-G construction to the Teissier distribution. The proposed distribution provides additional shape flexibility for modelling positive-valued observations and accommodates different density and hazard-rate shapes. Several statistical properties, including moments, the moment generating function,
quantile function, and order statistics, are derived. Maximum likelihood, maximum product spacing, and
Bayesian methods are considered for parameter estimation, and simulation results demonstrate improving estimation accuracy with increasing sample size. A median-based regression model is further developed for the KTD, with its finite-sample performance examined through simulation. The practical utility of the proposed regression model is demonstrated through an application to monthly gridded rainfall data from the Northwest Himalayas, incorporating annual and semi-annual harmonic terms to capture seasonal variation. Its performance is assessed against Kumaraswamy and beta regression using residual-based goodness-of-fit diagnostics and likelihood-based model selection. The results demonstrate effectiveness of the proposed distribution for modelling heterogeneous and skewed positive-valued rainfall data.
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All authors Kamana Mishra, Neeraj Poonia, Tanmay Kayal, Sarita Azad
Statistics Applications
Estimating water levels in the High Plains Aquifer by synthesizing satellite data with groundwater well observations
Anis Pakrashi, Murali Haran and Shan Zuidema
The High Plains Aquifer (HPA) is a critical water resource in the Central United States, yet its depletion remains a major concern. While the
Gravity Recovery and
Climate Experiment (GRACE) satellite mission provides large-scale estimates of
liquid water equivalent thickness (LWET), its coarse spatial resolution (approx. 24 km) limits local inference. In contrast, well observations from the National Ground-Water Monitoring Network (NGWMN) offer valuable but spatially sparse measurements of depth-to-groundwater. In this paper, we develop a downscaling framework for the satellite data that integrates the two sources and
covariates using a
Bayesian hierarchical framework. Our model uses a latent Gaussian Markov Random Field (GMRF) that describes the groundwater storage at a high spatial resolution. To address computational issues, we use a basis representation approach specified via the Moran basis. We find that fine-scale
covariates like irrigation intensity and precipitation help refine spatial predictions. We thus provide, to our knowledge, the first statistically-rigorous approach for downscaling groundwater information based on GRACE satellite data and NGWMN groundwater measurements. Our approach yields high-resolution estimates of groundwater variations across the HPA from 2002–2022. The resulting fine-scale inference provides valuable insights into groundwater dynamics, highlighting the effects of land use and local extraction patterns.
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Statistics Applications · Cross-listed from stat.ME
Nonparametric Hypothesis Testing of High-dimensional Clustering With Application to Single-cell RNA Data
Yifan Dai, Di Wu and Yufeng Liu
Single-
cell RNA sequencing studies routinely use clustering to define putative
cell types and
cell states, yet the observed separation may arise from sampling variability rather than genuine biological heterogeneity. This paper studies formal significance testing of such clustering structure in high-dimensional data. Existing SigClust methods assess clustering significance through Monte Carlo simulation under a Gaussian single-cluster null, but this assumption can be unreliable for normalized gene expression data and other non-Gaussian settings. We propose SigClust-LCP, a nonparametric extension that models a single cluster by a log-concave distribution. To make this approach computationally feasible in moderate to high dimensions, we develop a score-matching
estimator for log-concave projection inspired by recent generative modeling ideas. We establish theoretical guarantees for the
estimator and for its use in clustering significance testing. Simulations show that SigClust-LCP controls Type-I error more reliably than existing methods across a range of unimodal and mixture distributions while retaining competitive power. In a single-
cell RNA sequencing analysis of Hydra
cells, the method avoids spurious subclusters within annotated
cell populations and supports biologically meaningful separation across lineages and body-axis regions.
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Statistics Applications · Cross-listed from physics.soc-ph
One equation allocates playing time in competitive team sports: the rulebook sets the arithmetic and the league sets the habit
Gustavo Pedro Ricou
Every team sport that lets a team replace players rations the replacements, and the ration settles who plays and for how long. Across eight codes, three in both sexes, we measure how playing time is allocated and find one equation behind it, complete in the one-way codes, its terms separating what the rulebook fixes from what a competition chooses. Under scarcity every league behaves alike: loaded starters are kept on at the same rate on four continents. Under freedom each expresses a preference, and the size of a league's departure is priced near one-for-one by what its own withdrawal minute prices (lambda = 0.87, 95% interval 0.54 to 1.21, twelve leagues), a law confirmed in four out-of-sample predictions and refused in one. The ordering of leagues by appetite persists across a rule change, and club wealth does not price it. Rules are the geometry of a competition; culture is its material.
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Statistics Applications
Symptom clusters in Long COVID in the UK: prospective community-based cohort study using unsupervised machine learning
Jasmine Aherne, Ines Henriques-Cadby and Thomas House
Long COVID is a condition usually defined by persisting symptoms following infection by the SARS-CoV-2 virus beyond the acute phase of infection. The condition has a significant impact on healthcare systems, the economy, and the individuals living with it. Due to the diverse and extensive symptomatology of long COVID, symptom co-occurrence tracking can be used to capture patient experiences and improve understanding, diagnosis, and management. Here, we leverage the UK Office for National Statistics (ONS) COVID-19 Infection Survey (CIS). The CIS was run between April 2020 and March 2023. On February 3, 2021, the ONS launched a new CIS question evaluating self-reported symptom persistence of 23 long COVID symptoms post self-reported COVID-19 infection. We use Jaccard symptom-by symptom distance
matrices, derived from the binary survey responses of the presence of each symptom. Three methods are then used to visualise symptom co-occurrence: heatmaps, non-metric multidimensional scaling, and agglomerative hierarchical clustering with complete linkage. We split our analysis into two parts, first looking at all long COVID survey responses (n = 207,319) and then looking at responses stratified by time-since-onset of long COVID up to 24 months (n = 30,224 at zero months-since-onset). We find higher symptom co-occurrence in prolonged long COVID. We also find clusters of neurological/systemic symptoms, gastrointestinal symptoms, and respiratory symptoms, with separability in symptom co-occurrence by organ system becoming less pronounced as time-since-onset of long COVID increases. Shortness of breath, weakness/tiredness, and muscle ache present as core symptoms long COVID. We demonstrate that the symptom experience of long COVID evolves from early stages to late stages with higher symptom burden and multi-systemic presentation. We also find three possible phenotypes of early long COVID.
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Statistics Applications
Multi-Fidelity Gaussian Processes for Translational Modelling of Clinical Outcomes
Isaac S. Hayden, Alicia D'Souza, Steven Niederer et al. (+1 more)
Bridging the gap between animal and human experiments remains a major challenge in translational medicine, particularly in early drug development. Progress is constrained by financial cost, the difficulty of integrating heterogeneous in vitro and in vivo data, and the desire to reduce the use of animal testing balanced against minimising the risk to human participants. We present a statistical machine learning framework using multi-fidelity Gaussian processes, in which animal studies are considered as lower fidelity but informative approximations to human experiments. This allows cross-species similarities and nonlinear exposure-response relationships to be learned simultaneously, enabling principled extrapolation between species while quantifying uncertainty. By leveraging information from multiple experimental fidelities, our method improves estimation of clinically relevant quantities of interest and supports the replacement, reduction, and refinement of in vivo testing. We first illustrate this approach in a simulated scenario, before validating it on real clinical data. We simulate data for drug-induced QT-interval prolongation, a key cardiac safety assessment required for regulatory approval. This framework provides a probabilistic surrogate capable of integrating in vitro pharmacology, animal experiments and human data within a unified statistical model. Crucially, it achieves this at no additional experimental cost while also enabling transfer learning across compounds. As a result, predictions and uncertainty quantification for new drugs can be generated from in vitro findings alone, providing additional efficiency gains and accelerating decision making. For validation, we use a clinical
dataset measuring change in heart rate under autonomic blockade, which represents some of the challenges commonly found in multi-species
datasets.
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All authors Isaac S. Hayden, Alicia D'Souza, Steven Niederer, Sarah Filippi
Statistics Applications · Cross-listed from stat.ME
Time-dependent two-way partial AUC and partial Youden Index estimator for right censored data
Arpan Sanyal, Sudheesh Kumar Kattumannil and Ayon Ganguly
In medical research, it is often of interest to evaluate the predictive performance of a biomarker. Statistical approaches based on the Receiver Operating Characteristic (ROC) curve and its summary measures, such as the area under the curve (AUC) and the Youden index, are widely used to evaluate the prognostic performance of these biomarkers. In time-to-event studies, ROC analysis poses additional challenges due to change in disease status over time and the presence of censored individuals. To address these issues, time-dependent ROC curves were introduced. In this paper, we propose a non-parametric
estimator of the time-dependent two-way partial AUC for right-censored data. We also discuss the partial Youden index and the associated optimal biomarker cutoff
estimator for the right-censored data. We conduct an extensive simulation study to investigate the finite sample performance of the proposed
estimators. The simulation study indicates that the proposed non-parametric
estimators efficiently account for right censoring. Finally, we illustrate the proposed methods using two real data sets, one from the Primary Biliary Cirrhosis study and the other from the Molecular Taxonomy of Breast Cancer International Consortium trial.
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Statistics Applications
Pricing rides as option contracts: guarantees and memberships under travel-time uncertainty
Mohamad Elmasri, Mingze Li and Yunran Wei
Modern ride-share platforms must commit to a price before a trip is taken, yet the realized fare depends on travel time that is uncertain at the moment of sale, which can occur days in advance. The upfront price thus decomposes into the expected fare and the premium on an insurance claim whose payoff is the shortfall between the realized and promised prices. This work computes the fair premium for such a claim, following from contingent-claim pricing. Recent advances in travel-time distribution modeling cast the asymptotic distribution of travel time as a Brownian motion on a metric graph carrying a cyclostationary travel-time process. We thus derive closed-form premiums under both a population and a route-conditional travel-time law. A single pricing equation then covers products of increasing informational difficulty, such as on-demand and scheduled rides and capped-membership and commuter products. To price on sparse data, we develop route and travel-time samplers and validate them out of sample on 2014 Quebec City GPS trips, where they reproduce the empirical trip-time distribution. We show that guarantee premiums are inexpensive, typically under 5% of the fare. Conditioning on the realized route roughly halves the premium while reducing tail risk. Analyzing membership abuse, we show that adverse selection acts precisely along the dimension the price fails to condition on, yielding a design principle: subsidies additive in the fare, such as a fixed per-ride discount, leave marginal incentives unchanged and are abuse-proof by construction, with deterministic closed-form cost.
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Statistics Applications
The Periodically Correlated Components of Measles in New York City using the Variable Band-pass Periodic Block Bootstrap
Anastazia Valachovic, Susan P. Opar and Edward Valachovic
Measles, a highly contagious, deadly virus, is at risk of losing its eradication status in the Unites States. Understanding the pattern, including seasonality, of measles could provide great benefit for forecasting, prevention, and public health preparedness as the virus re-emerges. The novel Variable Band-pass Periodic Block Bootstrap (VBPBB), which suppresses noise and interfering signals, is more efficient and statistically powerful to find periodic components compared to other existing methods. Using this method, we have found several significant periodic components in historical New York City measles cases which other methods were incapable of identifying. These findings give us a reusable method for understanding measles and other diseases and greater insight into what may occur should measles vaccine rates continue to fall.
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