Statistics Applications · Cross-listed from astro-ph.IM
The Catastrophic Consequences of Agnosticism for Life Searches and a Possible Workaround
David Kipping
Planned and ongoing searches for life, both biological and technological, confront an epistemic barrier concerning false positives - namely, that we don't know what we don't know. The most defensible and agnostic approach is to adopt diffuse (uninformative) priors, not only for the prevalence of life, but also for the prevalence of confounders. We evaluate the resulting Bayes factors between the null and life hypotheses for an idealized experiment with $N_{pos}$ positive labels (biosignature detections) among $N_{tot}$ targets with various priors. Using diffuse priors, the consequences are catastrophic for life detection, requiring at least ${\sim}10^4$ (for some priors ${\sim}10^{13}$) surveyed targets to ever obtain "strong evidence" for life. Accordingly, an HWO-scale survey with $N_{tot}{\sim}25$ would have no prospect of achieving this goal. A previously suggested workaround is to forgo the agnostic confounder prior, by asserting some upper limit on it for example, but we find that the results can be highly sensitive to this choice - as well as difficult to justify. Instead, we suggest a novel solution that retains agnosticism: by dividing the sample into two groups for which the prevalence of life differs, but the confounder rate is global. We show that a $N_{tot}=24$ survey could expect 24% of possible outcomes to produce strong life detections with this strategy, rising to $\geq50$% for $N_{tot}\geq76$. However, AB-testing introduces its own unique challenges to survey design, requiring two groups with differing life prevalence rates (ideally greatly so) but a global confounder rate.
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Machine Learning (Statistics) · Cross-listed from cs.LG
Joint Energy Management and Coordinated AIGC Workload Scheduling for Distributed Data Centers: A Diffusion-Aided Reward Shaping Approach
Yang Fu, Peng Qin, Liming Chen et al. (+3 more)
Artificial intelligence-generated content (AIGC) has emerged as a transformative paradigm for automating the creation of diverse and customized content, giving rise to rapidly growing computational workloads in cloud data centers. It is imperative for AIGC service providers (ASPs) to strategically schedule AIGC workloads to reduce data center energy costs while guaranteeing high-quality content generation. However, the distinctive characteristics of AIGC services pose critical challenges, including model heterogeneity across ASPs, implicit service quality evaluation, and complex inference process control. To tackle these challenges, we propose a joint energy management and coordinated AIGC workload scheduling framework, which introduces an explicit mathematical characterization of service quality to promote both job transfer among ASPs and fine-grained inference process configuration. Moreover, various energy resources within data centers are jointly considered to enhance power usage flexibility. Subsequently, a system utility maximization problem is formulated to balance AIGC service revenue with operational penalties and costs. Nevertheless, the strong coupling among job scheduling decisions induces severe reward sparsity, which limits the effectiveness of existing deep reinforcement learning (DRL)
algorithms. To address this issue, we develop a
diffusion model-aided reward shaping approach to synthesize complementary reward signals through a multi-step denoising process. This approach is seamlessly integrated with DRL to enable efficient learning of scheduling policies under sparse environmental feedback. Experiments based on real-world models and
datasets demonstrate that our scheme effectively accommodates electricity price fluctuations and AIGC model heterogeneity, while achieving superior learning convergence and system utility compared with
benchmark methods.
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All authors Yang Fu, Peng Qin, Liming Chen, Zihao Zhang, Hao Yu, Yifei Wang
Statistical Computation · Cross-listed from cs.LG
ISAAC: Auditing Causal Reasoning in Deep Models for Drug-Target Interaction
Barbara Tarantino, Sun Kim, Yijingxiu Lu et al. (+1 more)
Deep learning models for drug–target interaction (DTI) prediction often achieve strong
benchmark performance without necessarily relying on mechanistically meaningful molecular features, a limitation that standard accuracy-based evaluation cannot detect. We introduce ISAAC (Intervention-based Structural
Auditing Approach for Causal
Reasoning), a post-hoc framework that evaluates prior-relative structural sensitivity by probing frozen models through matched mechanistic and spurious input-level interventions, independently of predictive accuracy. Applied to three sequence-based DTI architectures on the Davis
benchmark, ISAAC reveals approximately 25% relative differences in
reasoning scores across models with comparable AUROC (within around 3%), stable across training and intervention seeds and two distinct perturbation operators. These discrepancies, undetectable under conventional accuracy metrics, motivate the use of post-hoc structural
auditing as a complement to standard performance evaluation in scientific machine learning for molecular modeling.
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All authors Barbara Tarantino, Sun Kim, Yijingxiu Lu, Paolo Giudici
Statistics Theory
Entropic Strict Minimum Message Length and Its Connections to PAC-Bayes and NML
Enes Makalic and Daniel F. Schmidt
We introduce entropic strict minimum message length (SMML), a risk-sensitive generalization of strict minimum message length coding. The proposed criterion replaces expected two-part codelength under the prior predictive distribution with an exponential certainty equivalent, thereby defining a one-parameter family of coding rules that interpolates between
Bayesian average-case coding and worst-case minimax coding. We show that ordinary SMML is recovered in the risk-neutral limit, while the extreme risk-sensitive limit yields a minimax codelength criterion. Applying the same entropic soft maximum to regret relative to the oracle maximum likelihood codelength recovers the normalized maximum likelihood (NML) minimax-regret principle. We further prove that entropic SMML admits a variational characterization as a Kullback–Leibler-regularized worst-case expected codelength, giving it a PAC–Bayes-type interpretation. We establish joint \(n\)–\(\tau\) asymptotics that identify how the risk parameter must scale with sample size in order to recover
Bayesian average-case, intermediate robust, and worst-case minimax coding behavior. For regular exponential families, the fixed-codebook partition remains affine in sufficient-statistic space, while the codepoints satisfy a tilted moment-matching condition and admit an interpretation as tilted Bregman centroids. These results position entropic SMML as an information theoretic bridge between MML, PAC–Bayes, and MDL.
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Statistics Theory · Cross-listed from econ.EM
Fast Monte-Carlo
Irene Aldridge
This paper proposes an
eigenvalue-based small-sample approximation of the celebrated Markov Chain Monte Carlo that delivers an invariant steady-state distribution that is consistent with traditional Monte Carlo methods. The proposed
eigenvalue-based methodology reduces the number of paths required for Monte Carlo from as many as 1,000,000 to as few as 10 (depending on the simulation time horizon $T$), and delivers comparable, distributionally robust results, as measured by the Wasserstein distance. The proposed methodology also produces a significant variance reduction in the steady-state distribution.
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Statistics Theory
Sharp regret-Hellinger bounds for Gaussian empirical Bayes via polynomial approximation
Jiafeng Chen and Yihong Wu
A central problem in the theory of empirical Bayes is to control the regret (excess risk) of a learned Bayes rule by the Hellinger distance between the estimated and true marginal densities. In the normal means model, the classical result of Jiang and Zhang (2009) achieves this only after regularizing the Bayes rule and incurs an extraneous cubic logarithmic factor through a delicate recursive argument. This paper introduces a new technique, based on
polynomial approximation and Bernstein-type inequalities for weighted $L_2$ norms, that bounds the unregularized regret directly. The method is conceptually simpler and yields sharper, sometimes optimal, regret bounds. For compactly supported priors, we prove the sharp bound that the regret is $O(\epsilon^2 \frac{\log(1/\epsilon)}{\log\log(1/\epsilon)})$, where $\epsilon$ is the Hellinger distance between the marginal densities. The same method also extends to priors with exponential tails. Conversely, we show that regularization is genuinely necessary for heavy-tailed priors under only bounded moment assumptions. As statistical consequences, we obtain improved regret bounds for the nonparametric maximum likelihood
estimator (NPMLE). Notably, for compactly supported priors, by determining the optimal Hellinger rate of mixture density estimation, we show that the optimal regret for sample size $n$ scales as $\Theta(\frac{1}{n}(\frac{\log n}{\log\log n})^2)$, attained by the NPMLE within a $\log\log n$ factor.
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Statistical Methodology
Neural Generative Distributional Regression
Jinhang Chai, Jianqing Fan and Yihong Gu
Any continuous conditional distribution of $Y$ given $X$ can be generated from a transform of a known noise distribution $U$ such as the uniform or normal distribution via $Y = g(X, U)$. This paper provides an
estimator of such a generative transformation $g$ by minimizing the empirical energy distance between distributions of $Y$ and $g(X, U)$, and implements it via neural networks. The estimated distribution can then be readily applied to downstream tasks such as conditional moment estimation, predictive interval construction, and conditional density estimation. By leveraging the representation power of neural networks, the
estimator can adaptively exploit low-dimensional structures in a purely algorithmic manner. Theoretically, we establish an oracle inequality attaining the adaptive optimal nonparametric rates. Numerical simulations and real data analysis further demonstrate the practical effectiveness of the proposed method.
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Machine Learning (Statistics) · Cross-listed from cs.LG
Large margin classifier with graph-based adaptive regularization
Vítor M. Hanriot, Turíbio T. Salis, Luiz C.B. Torres et al. (+2 more)
This paper introduces the use of per-class regularization hyperparameters in Gabriel graph-based binary classifiers. We demonstrate how the quality index used for regularization behaves both in the margin region and in the presence of outliers, and how incorporating this regularization flexibility can lead to solutions that effectively eliminate outliers while training the classifier. We also show how it can address class imbalance by generating higher and lower thresholds for the majority and minority classes, respectively. Thus, rather than having a single solution based on fixed thresholds, flexible thresholds expand the solution space and can be optimized through hyperparameter tuning
algorithms. Friedman test shows that flexible thresholds are capable of improving Gabriel graph-based classifiers.
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All authors Vítor M. Hanriot, Turíbio T. Salis, Luiz C.B. Torres, Frederico Coelho, Antonio P. Braga
Machine Learning (Statistics)
MIRA: A Score for Conditional Distribution Accuracy and Model Comparison
Sammy Sharief, Justine Zeghal, Gabriel Missael Barco et al. (+3 more)
We introduce Mira, a sample-based score for assessing the accuracy of a candidate conditional distribution using only joint samples from the true data-generating process. Relying on the principle that distributions coincide if they assign equal probability mass to all regions, we derive an analytic expression for the Mira statistic, whose average defines the Mira score. This formulation further allows us to compute theoretical reference values and uncertainty estimates when the candidate distribution matches the true one. This framework enables model comparison by quantifying the
alignment between the conditional distribution of a candidate model and the true data generating process. Consequently, Mira enables
Bayesian model comparison through direct posterior validation, bypassing the challenging evidence computation. We demonstrate its effectiveness across several toy problems and
Bayesian inference tasks.
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All authors Sammy Sharief, Justine Zeghal, Gabriel Missael Barco, Pablo Lemos, Yashar Hezaveh, Laurence Perreault-Levasseur
Statistical Methodology
Shifted asymmetric Laplace mixtures of experts
Sphiwe B. Skhosana and Hien Duy Nguyen
Mixtures of experts (MoE) models provide a flexible framework for modelling heterogeneity in data for regression and model-based clustering and classification. MoE models for regression are typically based on the Gaussian assumption for the expert distributions. To robustify the MoE framework with respect to data exhibiting skewness, heavy tails and outliers, we propose a robust non-normal MoE model using the shifted asymmetric Laplace (SAL) distribution. The proposed SALMoE model overcomes the limitations of the Gaussian MoE model when the observed data are asymmetric and heavy-tailed. Through a combination of the minorization-maximization (MM)
algorithm with the classical Expectation-Maximization (EM), we develop a dedicated hybrid EM-MM
algorithm to estimate the parameters of the SALMoE model. The EM-MM
algorithm is shown to yield a nondecreasing observed log-likelihood. A simulation study demonstrates the robustness and practical utility of the proposed model. Finally, the SALMoE model is applied to two real-world economic
datasets.
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Statistics Theory · Cross-listed from econ.EM
Estimation and Inference for the $\tau$-Quantile of Individual Heterogeneous Coefficient
Antonio F. Galvao, Ulrich Hounyo and Jiahao Lin
This paper proposes estimation and inference procedures for
quantiles of the heterogeneous individual-specific coefficients in panel data. Unlike conventional panel
quantile regression, which focuses on outcome heterogeneity, our approach targets the $\tau$-
quantile of the cross-sectional distribution of individual-specific slopes. We establish the asymptotic theory under both
stochastic and deterministic designs, with convergence rates $\sqrt{N}$ and $\sqrt{N\sqrt{T}}$, respectively. We also develop two corresponding bootstrap procedures for practical inference, and formally establish their validity. The suggested methods are of practical interest since they require weaker sample size growth conditions than standard fixed-effect
quantile regression, and accommodate large $N$ settings. Numerical simulations and an empirical application illustrate the empirical effectiveness of the methods under both designs.
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Statistics Applications · Cross-listed from cs.LG
Deep learning-based pavement performance modeling using multiple distress indicators and road work history
Lu Gao, Zhe Han and Yunshen Chen
The deterioration of pavement is a complex and dynamic process determined by different factors including material, environment, design, and some other unobserved variables. Accurate predictions of pavement condition can help maximize the use of available resources for pavement management agencies through better coordinated preservation and maintenance activities. This paper uses deep neural networks such as the convolutional neural network (CNN) and the long short-term
memory (LSTM) to model the pavement deterioration process. In this paper, pavement condition data and maintenance and rehabilitation history collected by the Texas Department of Transportation over the past 18 years were used. Twenty-one flexible pavement condition indicators, including cracking, rutting, raveling, and roughness, collected from more than 100,000 pavement sections were included in the proposed models. Promising preliminary results were obtained. Case study results show that the proposed CNN model outperforms standard machine learning models in predicting pavement condition values.
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Machine Learning (Statistics)
Extrapolation in Statistical Learning with Extreme Value Theory
Sebastian Engelke, Nicola Gnecco and Anne Sabourin
Extreme value theory provides rigorous theory and statistical tools for extrapolation in machine learning, particularly in settings where traditional methods struggle due to data scarcity in the tails. A broad range of tasks benefit from these advances, including regression and classification beyond the training data, extreme
quantile regression, supervised and unsupervised dimension reduction, generative artificial intelligence and anomaly detection. This review synthesizes recent developments in these fields at the intersection of statistical learning and extreme value theory, with a focus on principled methods based on asymptotically motivated representations of the tail of univariate and multivariate distributions. We consider different theoretical frameworks for both asymptotically dependent and independent data and discuss how they translate into efficient statistical methods for extrapolation to extreme regions. By addressing both theoretical and practical aspects, we offer a comprehensive overview of the state-of-the-art in this quickly evolving field, and identify promising directions for future research.
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Machine Learning (Statistics)
Adaptive Estimation and Inference in Semi-parametric Heterogeneous Clustered Multitask Learning via Neyman Orthogonality
Hanxiao Chen and Debarghya Mukherjee
We study clustered multitask learning in a semiparametric setting where tasks share a latent cluster structure in their target parameters but exhibit heterogeneous, potentially infinite-dimensional nuisance components. Such heterogeneity poses a major challenge for existing multitask learning methods, which typically rely on aligned feature spaces or homogeneous task structures. To address this challenge, we propose an adaptive fused orthogonal
estimator that integrates Neyman-orthogonal losses with data-driven pairwise fusion penalties. Our framework leverages task-specific pilot estimates to calibrate the fusion penalties and combines adaptive aggregation with orthogonalization to mitigate the impact of nuisance-parameter estimation error. Theoretically, we show that the proposed
estimator achieves exact recovery of the latent clustering with high probability and attains pooled parametric convergence rates proportional to cluster size. Moreover, we establish asymptotic normality and show that, asymptotically, our
estimator matches the performance of an oracle procedure that knows the true clustering in advance. Empirically, we show that the proposed method consistently outperforms strong baselines in various simulation setups. A real-world application to U.S. residential energy consumption demonstrates the effectiveness of our approach in uncovering meaningful regional clustering in electricity price elasticity, showcasing the efficacy of our method.
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Statistical Methodology
Probabilities of Causation for Continuous Outcomes: Bounds and Identification
Jile Chaoge, Kesen Han, Fahui Liu et al. (+1 more)
The probability of necessity (PN), which quantifies the probability that an observed event would not have occurred in the absence of the treatment, is a central estimand in attribution analysis. While PN has been extensively studied for binary outcomes and has recently been developed for ordinal outcomes, a formal framework for continuous outcomes remains underdeveloped. To address this gap, we propose the general probability of necessity (GPN) for continuous outcomes, a setting that is substantially more challenging than the binary and ordinal cases. Rather than imposing strong identifiability assumptions, we adopt a partial identification perspective and derive sharp lower and upper bounds under standard assumptions of ignorability and monotonicity. We further introduce a copula-based framework that exploits dependence information between potential outcomes to tighten these bounds. Simulation studies and real-world applications demonstrate the effectiveness of our method.
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All authors Jile Chaoge, Kesen Han, Fahui Liu, Peng Wu