Papers

EEG-guided target speaker extraction is challenging under in-trial auditory attention switching, where neural noise and intrinsic latency can delay or destabilize attention tracking. Conventional methods struggle with dynamic switches and often cause discontinuities at switching points. Therefore, we propose SAGE, a switch-aware EEG-guided soft gating framework that treats in-trial switching as dynamic selection. SAGE generates two candidate speech streams with a robust separator and uses an EEG-guided switch-aware gating module to produce smooth fusion weights and suppress transition artifacts. We further integrate latency-compensated alignment and an uncertainty-driven conservative strategy to handle latency discrepancies and fluctuating EEG reliability. SAGE outperforms baselines, achieving 8.67 dB SI-SDR and 88.24% STOI while reducing average switching latency to 2.04 s. By coupling neural decoding with speech separation, it enables robust target extraction in dynamic scenarios.

Digital biomarkers of cardiovascular aging, often termed heart or vascular age, have been widely studied, but most rely on resting electrocardiography (ECG), imaging, or specialized vascular assessments. Evidence linking wearable photoplethysmography (PPG) to arterial stiffness and hypertension remains limited. We developed an ECG-guided cross-modal framework that uses synchronized smartwatch ECG to enhance PPG representation learning during pretraining while requiring only PPG at inference. The study included three OPPO cohorts across China, comprising 581,804 participants and 7,452,131 recordings. The Vascular Health Study cohort supported ECG-PPG self-supervised pretraining, fine-tuning, and internal validation, while two external cohorts assessed associations with pulse wave velocity (PWV) and prevalent hypertension. Combining subject-aware learning with ECG-PPG contrastive alignment, the PPG-only model achieved subject-level mean absolute errors of 5.895 years (Pearson r=0.819) in the PWV cohort and 4.344 years (r=0.800) in the home blood pressure monitoring cohort. Aggregating repeated recordings further improved short-term stability. After adjustment for chronological age, heart age gap was associated with PWV (partial r=0.2627, P<0.001); each 1-year increase corresponded to 0.062 m/s higher PWV, and accelerated versus decelerated heart aging was associated with 0.91 m/s higher adjusted PWV. Each 1-SD increase in adjusted heart age gap was associated with greater odds of prevalent hypertension (OR 1.72, 95% CI 1.49-1.99), while the highest versus lowest quartile had an OR of 4.25. These findings support smartwatch PPG-derived heart age gap as a scalable digital biomarker of arterial stiffness and prevalent hypertension.

Achieving robust EEG-based auditory attention switch decoding (AASD) is crucial for intelligent hearing aids. However, its application is limited as EEG non-stationarity complicates sequential decision-making, and insufficient control of potential confounding factors may overestimate performance. Therefore, we propose a state-guided adaptive decision (SGAD) framework that infers attention transition states via causal state detection and dynamically modulates temporal smoothing through state-guided adaptive gating. We further introduce six hierarchical evaluation protocols to assess generalization across audio, speaker, and subject dimensions. Experimental results show that SGAD improves decoding accuracy and stability while maintaining low response latency across evaluation scenarios. Performance variations across protocols further suggest data partition-related biases. Together, these findings advance robust AASD for neuro-steered hearing applications.